AR053972A1 - Procedimiento para produccion de 2 - cloro-4- nitroimidazol - Google Patents

Procedimiento para produccion de 2 - cloro-4- nitroimidazol

Info

Publication number
AR053972A1
AR053972A1 ARP050103983A ARP050103983A AR053972A1 AR 053972 A1 AR053972 A1 AR 053972A1 AR P050103983 A ARP050103983 A AR P050103983A AR P050103983 A ARP050103983 A AR P050103983A AR 053972 A1 AR053972 A1 AR 053972A1
Authority
AR
Argentina
Prior art keywords
production
nitroimidazole
represented
nitroimidazol
chlorine
Prior art date
Application number
ARP050103983A
Other languages
English (en)
Inventor
Koichi Shinhama
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR053972A1 publication Critical patent/AR053972A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente provee un procedimiento de produccion de 2-cloro-4-nitroimidazol representado por la formula (1) que comprende una reaccion del compuesto 1-alcoxialquil-2-bromo-4-nitroimidazol representado por la formula general (2) en donde R1 representa un grupo alquilo inferior, y n representa un entero de valor 1 a 3, con ácido clorhídrico. Reivindicacion 1: Un procedimiento para la produccion de 2-cloro-4-nitroimidazol caracterizado porque está representado por la formula (3) que comprende una reaccion de 1-alcoxialquilo-2-bromo-4-nitroimidazol representado por la formula general (4) en donde R1 representa un grupo alquilo inferior, y n representa un entero de valor 1 a 3, con ácido clorhídrico.
ARP050103983A 2004-09-27 2005-09-26 Procedimiento para produccion de 2 - cloro-4- nitroimidazol AR053972A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004278974 2004-09-27

Publications (1)

Publication Number Publication Date
AR053972A1 true AR053972A1 (es) 2007-05-30

Family

ID=35967026

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103983A AR053972A1 (es) 2004-09-27 2005-09-26 Procedimiento para produccion de 2 - cloro-4- nitroimidazol

Country Status (14)

Country Link
US (1) US20090082575A1 (es)
EP (1) EP1794132A2 (es)
KR (1) KR20070056105A (es)
CN (1) CN101027287A (es)
AR (1) AR053972A1 (es)
AU (1) AU2005288086A1 (es)
BR (1) BRPI0516009A (es)
CA (1) CA2580139A1 (es)
IL (1) IL182134A0 (es)
MX (1) MX2007003257A (es)
RU (1) RU2007115892A (es)
TW (1) TW200624422A (es)
WO (1) WO2006035960A2 (es)
ZA (1) ZA200702426B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2323990B1 (en) * 2008-08-21 2014-06-18 Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Methods for the production of 2-halo-4-nitroimidazole and intermediates thereof
CN103396369B (zh) * 2013-08-14 2016-03-23 盐城工学院 一种制备2-氯-4-硝基咪唑的方法
US11104650B2 (en) 2018-01-29 2021-08-31 Otsuka Pharmaceutical Co., Ltd. Process for production of 2-chloro-4-nitroimidazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368579B2 (en) * 2002-10-15 2008-05-06 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and process for producing the same
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound

Also Published As

Publication number Publication date
EP1794132A2 (en) 2007-06-13
AU2005288086A1 (en) 2006-04-06
RU2007115892A (ru) 2008-11-10
US20090082575A1 (en) 2009-03-26
BRPI0516009A (pt) 2008-08-19
CN101027287A (zh) 2007-08-29
KR20070056105A (ko) 2007-05-31
ZA200702426B (en) 2008-08-27
MX2007003257A (es) 2007-05-23
WO2006035960A3 (en) 2006-05-11
TW200624422A (en) 2006-07-16
IL182134A0 (en) 2007-07-24
WO2006035960A2 (en) 2006-04-06
CA2580139A1 (en) 2006-04-06

Similar Documents

Publication Publication Date Title
CO6210751A2 (es) Derivados de indolinona y procedimiento para su fabricacion
CR8640A (es) Proceso para producir un compuesto de 5-hidroxi-4-tiometilpirazol
AR050518A1 (es) Proceso de amonolisis para la preparacion de intermedarios para inhibidores de dpp iv
BRPI0606676A2 (pt) processos para a preparação de derivados de ácido 4-(fenóxi-5-metil-pirimidin-4-ilóxi)piperidina-1-carboxì lico e compostos relacionados
DE502005008057D1 (de) Substituierte cyclopenten-verbindungen
UA102817C2 (ru) Способ синтеза агомелатина
GEP20125512B (en) Process for synthesis of agomelatin
MX2010009860A (es) Sintesis total de salinosporamida a y sus analogos.
NZ601040A (en) Method of producing acrylic and methacrylic acid
EA200801893A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаления
TW200612959A (en) Method for preparing hydroxamic acids
AR064658A1 (es) Proceso para preparar duloxetina y sus compuestos relacionados, asi como tambien intermediarios utiles en la misma
BR112015018222A2 (pt) método para produzir um composto tricíclico, e composto tricíclico que pode ser produzido pelo referido método de produção
EA201270237A1 (ru) Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения, содержащие магний
CO6511211A2 (es) Composiciones estable de sns 595 y métodos de preparación
TW200738650A (en) Process for synthesis of aryloxy diaminopyrimidines
AR053972A1 (es) Procedimiento para produccion de 2 - cloro-4- nitroimidazol
BR112013003992A2 (pt) método de produção
AR049695A1 (es) Procedimiento para preparar un compuesto tiazol y compuesto intermediario de sintesis
NO20075930L (no) Fremgangsmate for fremstilling av alkalimetallsalt
DE602006001394D1 (de) Verfahren zur herstellung einer vorstufe von vitamin b1
IN2015DN01009A (es)
UA90940C2 (ru) Способ получения соединений 5-алкокси-4-гидроксиметилпиразола и соединения 5-алкокси-4-гидроксиметилпиразола
ATE466003T1 (de) Herstellung von 2-aminothiazol-5- carbonsäurederivaten
AR054874A1 (es) Metodo para producir un derivado de 5- hidroxi -1-alquilpirazol

Legal Events

Date Code Title Description
FA Abandonment or withdrawal