AR051350A1 - Vacuna de glucoproteina mucinosa (muc-1) - Google Patents
Vacuna de glucoproteina mucinosa (muc-1)Info
- Publication number
- AR051350A1 AR051350A1 ARP050101311A ARP050101311A AR051350A1 AR 051350 A1 AR051350 A1 AR 051350A1 AR P050101311 A ARP050101311 A AR P050101311A AR P050101311 A ARP050101311 A AR P050101311A AR 051350 A1 AR051350 A1 AR 051350A1
- Authority
- AR
- Argentina
- Prior art keywords
- muc
- subject
- amino acid
- acid sequence
- formulation
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 5
- 238000009472 formulation Methods 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- 102100034256 Mucin-1 Human genes 0.000 abstract 3
- 108010008707 Mucin-1 Proteins 0.000 abstract 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/00117—Mucins, e.g. MUC-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Método de tratamiento de un sujeto que sufre de cáncer, tal como cáncer de pulmon de células no pequenas o cáncer e prostata, que comprende administrarle a dicho sujeto una formulacion basada en MUC-1. La formulacion puede ser una vacuna liposomica basada en la formulacion MUC-1. Reivindicacion 1: Un método de tratamiento de un sujeto con cáncer de pulmon de células no pequenas, caracterizado porque comprende: (a) seleccionar para el tratamiento un sujeto que sufre e cáncer de pulmon de células no pequenas, y (b) administrarle a dicho sujeto, por un período de tiempo, una formulacion basada en MUC-1, donde dicha formulacion comprende un liposoma que contiene al menos un polipéptido que comprende la secuencia de aminoácidos seleccionada del grupo formado por la secuencia de aminoácidos de la SEQ ID N.:1, una variante de la secuencia de aminoácidos de la SEQ ID N.:1, la secuencia de aminoácidos de la SEQ ID N.:2 y una variante de la secuencia de aminoácidos de la SEQ ID N.:2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55813904P | 2004-04-01 | 2004-04-01 | |
US57680404P | 2004-06-04 | 2004-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR051350A1 true AR051350A1 (es) | 2007-01-10 |
Family
ID=35428714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101311A AR051350A1 (es) | 2004-04-01 | 2005-04-01 | Vacuna de glucoproteina mucinosa (muc-1) |
Country Status (16)
Country | Link |
---|---|
US (2) | US9173929B2 (es) |
EP (2) | EP1737485B1 (es) |
JP (3) | JP5590768B2 (es) |
CN (2) | CN103933556A (es) |
AR (1) | AR051350A1 (es) |
AU (1) | AU2005244675B2 (es) |
BR (1) | BRPI0509552A (es) |
CA (1) | CA2562990A1 (es) |
DK (2) | DK2524700T3 (es) |
ES (2) | ES2478006T3 (es) |
HK (1) | HK1109574A1 (es) |
HU (1) | HUE027378T2 (es) |
PL (2) | PL1737485T3 (es) |
PT (2) | PT1737485E (es) |
TW (2) | TW201204410A (es) |
WO (1) | WO2005112546A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE343375T1 (de) | 2001-03-27 | 2006-11-15 | Biomira Inc | Impfstoff zur modulation zwischen t1 und t2 immunantworten |
JP4527407B2 (ja) * | 2002-04-15 | 2010-08-18 | オンコサイレオン インコーポレーテッド | ワクチンとしての合成グリコリポペプチド |
TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
US8871250B2 (en) * | 2005-06-28 | 2014-10-28 | Oncothyreon Inc. | Method of treating patients with a mucinous glycoprotein (MUC-1) vaccine |
AU2012268892B2 (en) * | 2005-06-28 | 2016-05-26 | Oncothyreon Inc. | Method of Treating Patients with a Mucinous Glycoprotein (MUC-1) Vaccine |
WO2010002478A2 (en) | 2008-07-03 | 2010-01-07 | University Of Georgia Research Foundation, Inc. | Glycopeptide and uses thereof |
US20120034294A1 (en) * | 2008-12-17 | 2012-02-09 | Oncothyreon, Inc. | Method of making small liposomes |
WO2011054359A2 (en) * | 2009-11-06 | 2011-05-12 | University Of Copenhagen | Method for early detection of cancer |
EP2560989B1 (en) | 2010-04-19 | 2017-03-22 | Sumitomo Bakelite Co., Ltd. | Cancer-related glycopeptide epitopes, antibodies and methods of use |
CN105193724A (zh) * | 2011-02-24 | 2015-12-30 | 肿瘤防护公司 | 含有佐剂的以muc1 为基础的糖脂肽疫苗 |
EP4052721A1 (en) | 2011-06-24 | 2022-09-07 | NoNO Inc. | Combination therapy for ischemia |
DE102011085695A1 (de) * | 2011-11-03 | 2013-05-08 | Jörg Pohl | Einmalig dosierte Oxazaphosphorine zur Therapie von Krankheiten |
US9241970B2 (en) * | 2011-12-13 | 2016-01-26 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
SG11201509357WA (en) | 2013-05-14 | 2015-12-30 | Merck Patent Gmbh | Method of treating lung cancer by vaccination with muc-1 lipopeptide |
KR20160043103A (ko) * | 2013-08-21 | 2016-04-20 | 큐어백 아게 | 전립선암 치료를 위한 조성물 및 백신 |
WO2015058831A1 (en) | 2013-10-25 | 2015-04-30 | Merck Patent Gmbh | Elevated biomarker expression in lung cancer patients responding to treatment with muc-1 lipopeptide vaccines |
CN110393797A (zh) * | 2019-05-27 | 2019-11-01 | 南开大学 | 基于糖脂佐剂的糖肽疫苗的制备方法与应用 |
WO2022125956A1 (en) * | 2020-12-11 | 2022-06-16 | Trustees Of Boston University | Immunomodulatory lipopolysaccharide compositions |
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TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
US8871250B2 (en) | 2005-06-28 | 2014-10-28 | Oncothyreon Inc. | Method of treating patients with a mucinous glycoprotein (MUC-1) vaccine |
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-
2005
- 2005-03-31 TW TW100134756A patent/TW201204410A/zh unknown
- 2005-03-31 TW TW094110256A patent/TWI395591B/zh not_active IP Right Cessation
- 2005-04-01 HU HUE11196228A patent/HUE027378T2/en unknown
- 2005-04-01 BR BRPI0509552-2A patent/BRPI0509552A/pt not_active IP Right Cessation
- 2005-04-01 DK DK11196228.8T patent/DK2524700T3/en active
- 2005-04-01 CN CN201410053925.2A patent/CN103933556A/zh active Pending
- 2005-04-01 US US10/594,992 patent/US9173929B2/en not_active Expired - Fee Related
- 2005-04-01 ES ES05769609.8T patent/ES2478006T3/es active Active
- 2005-04-01 PT PT57696098T patent/PT1737485E/pt unknown
- 2005-04-01 PT PT111962288T patent/PT2524700E/pt unknown
- 2005-04-01 AU AU2005244675A patent/AU2005244675B2/en not_active Ceased
- 2005-04-01 DK DK05769609.8T patent/DK1737485T3/da active
- 2005-04-01 CA CA002562990A patent/CA2562990A1/en not_active Abandoned
- 2005-04-01 AR ARP050101311A patent/AR051350A1/es not_active Application Discontinuation
- 2005-04-01 WO PCT/IB2005/002479 patent/WO2005112546A2/en active Application Filing
- 2005-04-01 ES ES11196228.8T patent/ES2560808T3/es active Active
- 2005-04-01 CN CN200580017899.7A patent/CN1997388B/zh not_active Expired - Fee Related
- 2005-04-01 PL PL05769609T patent/PL1737485T3/pl unknown
- 2005-04-01 EP EP05769609.8A patent/EP1737485B1/en active Active
- 2005-04-01 PL PL11196228T patent/PL2524700T3/pl unknown
- 2005-04-01 EP EP11196228.8A patent/EP2524700B1/en active Active
- 2005-04-01 JP JP2007505675A patent/JP5590768B2/ja not_active Expired - Fee Related
-
2008
- 2008-01-10 HK HK08100332.9A patent/HK1109574A1/xx not_active IP Right Cessation
-
2011
- 2011-11-04 JP JP2011242039A patent/JP5868125B2/ja not_active Expired - Fee Related
-
2014
- 2014-05-15 JP JP2014101006A patent/JP2014177479A/ja active Pending
-
2015
- 2015-09-25 US US14/866,420 patent/US20160082093A1/en not_active Abandoned
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