AR050960A1 - Uso de un compuesto de 4-bencil-1,3-dihidro-imidazol-2-tiona sustituido o no sustituido para la preparacion de una composicion farmaceutica y dichos compuestos - Google Patents

Uso de un compuesto de 4-bencil-1,3-dihidro-imidazol-2-tiona sustituido o no sustituido para la preparacion de una composicion farmaceutica y dichos compuestos

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Publication number
AR050960A1
AR050960A1 ARP050104065A ARP050104065A AR050960A1 AR 050960 A1 AR050960 A1 AR 050960A1 AR P050104065 A ARP050104065 A AR P050104065A AR P050104065 A ARP050104065 A AR P050104065A AR 050960 A1 AR050960 A1 AR 050960A1
Authority
AR
Argentina
Prior art keywords
atoms
alkyl
aryl
group
independently selected
Prior art date
Application number
ARP050104065A
Other languages
English (en)
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AR050960A1 publication Critical patent/AR050960A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Endocrinology (AREA)

Abstract

Uso de compuestos de 4-bencil-1,3-dihidro-imidazol-2-tionas sustituidos y no sustituidos de la formula (1) donde n es un entero que oscila entre los valores de 0 a 5; R1 es independientemente seleccionado del grupo formado por alquilo C1-4, alquenilo C2-4, alquinilo C2-4, (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN9, C(O)OR5, (CH2)mSO2R5, arilo, heteroarilo, F, Cl, Br, I, fluoroalquilo C1-4 y de 1 a 9 átomos de F y fluoroalcoxi C1-4 y de 1 a 9 átomos de F, N3 y NO2, dicho heteroarilo contiene de 1 a 3 heteroátomos independientemente seleccionados a partir de O, N y S y dichos grupos arilos y hetearilos se encuantran opcionalmente sustituidos por 1 a 3 radicales seleccionados del grupo formado por alquilo C1-4, alquenilo C2-4, alquinilo C2- 4,es (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN9C(O)OR5, C(O)OR5, (CH2)mSO2R5, fluoroalquilo C1-4 y de 1 a 9 átomos de F, fluoroalcoxi C1-4 y de 1 a 9 átomos de F, N3 y NO2; m es un entero que oscila entre los valores de 0, 1, 2 o 3; R2 es H, alquilo C1-4, C(O)R5, y arilo o heteroarilo que contiene de 1 a 3 heteroátomos independientemente seleccionados de O, N y S y dicho arilo y grupos heteroarilos son opcionalmente sustituidos con 1 a 3 radicales seleccionados del grupo formado por alquilo C1-4, alquenilo C2-4, alquinilo C2-4, (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN9, C(O)OR5, (CH2)mSO2R5, fluoroalquilo C1-4 y de 1 a 9 átomos de F, N3 y NO2; R3 y R4 son independientemente seleccionados del grupo formado por H, alquilo C1-4, C(O)R5 y bencilo; R5 es independientemente H, alquilo C1-4, arilo o heteroarilo que contiene 1 a 3 heteroátomos independientemente seleccionados de O, N y S y dicho arilo y grupos heteroarilo son opcionalmente sustituidos por 1 a 3 radicales seleccionados del grupo formado por alquilo C1-4, alqueniloC2-4, alquinilo C2-4, (CH2)mOR2, (CH2)mNR3R4, (CH2)mC(O)OR5, C(O)OR5, (CH2)mSO2R5, fluoroalquilo C1-4 y de 1 a 9 átomos de F, fluoroalcoxi C1-4 y de 1 a 9 átomos de F, N3 y NO2, para preparar una composicion farmacéutica util para el tratamiento de los dolores cronicos, dolores viscerales, dolores neurofáticos, dolores de cornea, glaucoma, presion intraocular elevada, neuropatologías isquémicas, enfermedades neurodegenerativas, diarreas, congestion nasal, musculos espásticos, diuresis, síndrome de retiro, enfermedades neurodegenerativas, neuropatología optica, isquemia espinal, ataques, deficiencias de memoria y conocimiento, desordenes de déficit de atencion, psicosis, desordenes maníacos, ansiedad, depresion, hipertension, falla corazon congestivo, isquemia cardíaca, artritis, espondilitis, artritis gotoso, osteoartritis, artritis juvenil, enfermedades autoinmunes, eritematosis de lupus, inflamaciones gastrointestinales cronicas, enfermedad de Crohn, gastritis, síndrome del intestino irritable (IBS), dispepsia funcional, colitis ulcerativa o la combinacion de cualquiera de ellas. Reivindicacion 17: Un compuesto util para la preparacion de una composicion farmacéutica de acuerdo al uso de la reivindicacion 1, caracterizado porque se selecciona del grupo formado por los compuestos 1 a 6 que muestran la formula estructural que aparece abajo.
ARP050104065A 2004-09-28 2005-09-27 Uso de un compuesto de 4-bencil-1,3-dihidro-imidazol-2-tiona sustituido o no sustituido para la preparacion de una composicion farmaceutica y dichos compuestos AR050960A1 (es)

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WO2006036512A2 (en) 2006-04-06
TW200616622A (en) 2006-06-01
NZ553566A (en) 2010-11-26
MX2007003307A (es) 2007-05-16
CA2582071A1 (en) 2006-04-06
WO2006036512A3 (en) 2006-05-04
JP4986856B2 (ja) 2012-07-25
US8178571B2 (en) 2012-05-15
BRPI0516217A (pt) 2008-08-26
US20100298395A1 (en) 2010-11-25
CN101044120A (zh) 2007-09-26
US20120196911A1 (en) 2012-08-02
AU2005290013A1 (en) 2006-04-06
KR101202066B1 (ko) 2012-11-15
US20060069142A1 (en) 2006-03-30
JP2008514699A (ja) 2008-05-08
US7795292B2 (en) 2010-09-14
KR20070058533A (ko) 2007-06-08
CN101044120B (zh) 2011-06-15
EP1797044A2 (en) 2007-06-20

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