AR049402A1 - Derivados de piridazin-3-(2h)-ona - Google Patents
Derivados de piridazin-3-(2h)-onaInfo
- Publication number
- AR049402A1 AR049402A1 ARP050102489A ARP050102489A AR049402A1 AR 049402 A1 AR049402 A1 AR 049402A1 AR P050102489 A ARP050102489 A AR P050102489A AR P050102489 A ARP050102489 A AR P050102489A AR 049402 A1 AR049402 A1 AR 049402A1
- Authority
- AR
- Argentina
- Prior art keywords
- mono
- groups
- alkoxycarbonyl
- hydroxycarbonyl
- group
- Prior art date
Links
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000004442 acylamino group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000004414 alkyl thio group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000005110 aryl thio group Chemical group 0.000 abstract 4
- 125000004104 aryloxy group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- -1 hydroxy, hydroxycarbonyl Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P39/00—General protective or antinoxious agents
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- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Transplantation (AREA)
Abstract
Un compuesto de formula (1), en la que R1 representa : un átomo de hidrogeno; un grupo alquilo, alquenilo o alquinilo, que está opcionalmente sustituido con uno o más sustituyentes seleccionados de átomos de halogeno y grupo hidroxi,alcoxi, ariloxi, alquiltio, ariltio, oxo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo o mono- o di-alquilcarbamoilo; R2 representa un grupo heteroarilo monocíclico o policíclico, que está opcionalmente sustituido con uno o más sustituyentes seleccionados de: átomos de halogeno; grupos alquilo y alquileno, que están opcionalmente sustituidos con uno o más sustituyentes seleccionados de átomos de halogeno y grupos fenilo, hidroxi, alcoxi, ariloxi, alquiltio, ariltio, oxo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo o mono- o di-alquilcarbamoilo; grupos fenilo, hidroxi, hidroxicarbonilo, hiidroxialquilo, alcoxicarbonilo, alcoxi, cicloalcoxi, nitro, ciano, ariloxi, alquiltio, ariltio, alquilsulfinilo, alquilsulfonilo, alquilsulfamoilo, acilo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo o mono- o di-alquilcarbamoilo, ureido, N'-alquilureido, N',N'-dialquilureido, alquilsulfamido, aminosulfonilo, mono- o di-alquilaminosulfonilo, ciano, difluorometoxi o trifluorometoxi; R3 representa un átomo de hidrogeno o un grupo alquilcarbonilo en el que el grupo alquilo puede estar sustituido con uno o más sustituyentes seleccionados de átomos de halogeno y grupos fenilo, hidroxi, hidroxialquilo, alcoxi, ariloxi, alquiltio, ariltio, oxo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo, mono- o di-alquilcarbamoilo; R4 representa un grupo de formula: G-L1-(CRR')n-, en la que n es un numero entero de 0 a 3; R y R' se seleccionan independientemente del grupo que consiste en átomos de hidrogeno y grupos alquilo inferior; L1 es un fragmento enlazador seleccionado del grupo que consiste en un enlace directo, grupos -O-, -CO-, -NR''-, -O(CO)NR''-, -O(CO)O-, -O-(CO)-, -(CO)O-, -NR''-(CO)- y -O(R''O)(PO)O-, en los que R'' se selecciona del grupo que consiste en átomos de hidrogeno y grupos alquilo inferior; G se selecciona de átomos de hidrogeno y grupos alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, heterociclilo, arilo, arilalquilo y heteroarilo, estando dichos grupos opcionalmente sustituidos con uno o más sustituyentes seleccionados de: átomos de halogeno; grupos alquilo y alquenilo, que están opcionalmente sustituidos con uno o más sustituyentes seleccionados de átomos de halogeno; y grupos hidroxi, alcoxi, cicloalquiloxi, alquiltio, alquilsulfinilo, alquilsulfonilo, alquilsulfamoilo, amino, mono- o di-alquilamino, acilamino, nitro, acilo, hidroxicarbonilo, alcoxicarbonilo, carbamoilo, mono- o di-alquilcarbamoilo, ureido, N'-alquilureido, N'N'-dialquilureido, alquilsulfamido, amonosulfonilo, mono- o di- alquilaminosulfonilo, ciano, diflurometoxi o trifluorometoxi; y sus sales o N-oxidos farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200401500A ES2251866B1 (es) | 2004-06-18 | 2004-06-18 | Nuevos derivados de piridazin-3(2h)-ona. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049402A1 true AR049402A1 (es) | 2006-07-26 |
Family
ID=34956035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050102489A AR049402A1 (es) | 2004-06-18 | 2005-06-17 | Derivados de piridazin-3-(2h)-ona |
Country Status (24)
Country | Link |
---|---|
US (1) | US7960383B2 (es) |
EP (1) | EP1758869B1 (es) |
JP (1) | JP2008502628A (es) |
KR (1) | KR20070029808A (es) |
CN (1) | CN1964952A (es) |
AR (1) | AR049402A1 (es) |
AT (1) | ATE492538T1 (es) |
AU (1) | AU2005254659A1 (es) |
BR (1) | BRPI0511383A (es) |
CA (1) | CA2570170A1 (es) |
DE (1) | DE602005025478D1 (es) |
EC (1) | ECSP067058A (es) |
ES (2) | ES2251866B1 (es) |
IL (1) | IL179734A0 (es) |
MX (1) | MXPA06013593A (es) |
NO (1) | NO20070321L (es) |
PE (1) | PE20060436A1 (es) |
RU (1) | RU2376293C2 (es) |
SG (1) | SG155909A1 (es) |
TW (1) | TW200612951A (es) |
UA (1) | UA88472C2 (es) |
UY (1) | UY28958A1 (es) |
WO (1) | WO2005123692A1 (es) |
ZA (1) | ZA200609403B (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
AU2004293018B2 (en) * | 2003-11-19 | 2010-02-18 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
ES2251867B1 (es) * | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
PT2361905E (pt) * | 2005-05-18 | 2013-03-18 | Array Biopharma Inc | Inibidores heterocíclicos de mek e seus métodos de utilização |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
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TW200612951A (en) | 2006-05-01 |
US7960383B2 (en) | 2011-06-14 |
ATE492538T1 (de) | 2011-01-15 |
JP2008502628A (ja) | 2008-01-31 |
WO2005123692A8 (en) | 2006-05-04 |
EP1758869A1 (en) | 2007-03-07 |
UY28958A1 (es) | 2005-08-31 |
ZA200609403B (en) | 2007-12-27 |
MXPA06013593A (es) | 2007-03-15 |
SG155909A1 (en) | 2009-10-29 |
ES2251866A1 (es) | 2006-05-01 |
NO20070321L (no) | 2007-03-12 |
PE20060436A1 (es) | 2006-06-02 |
IL179734A0 (en) | 2007-05-15 |
US20080280918A1 (en) | 2008-11-13 |
CA2570170A1 (en) | 2005-12-29 |
WO2005123692A1 (en) | 2005-12-29 |
BRPI0511383A (pt) | 2007-12-26 |
AU2005254659A1 (en) | 2005-12-29 |
RU2007101654A (ru) | 2008-07-27 |
EP1758869B1 (en) | 2010-12-22 |
KR20070029808A (ko) | 2007-03-14 |
UA88472C2 (en) | 2009-10-26 |
ES2358335T3 (es) | 2011-05-09 |
DE602005025478D1 (de) | 2011-02-03 |
RU2376293C2 (ru) | 2009-12-20 |
CN1964952A (zh) | 2007-05-16 |
ECSP067058A (es) | 2007-03-29 |
ES2251866B1 (es) | 2007-06-16 |
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