AR049402A1 - Derivados de piridazin-3-(2h)-ona - Google Patents

Derivados de piridazin-3-(2h)-ona

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Publication number
AR049402A1
AR049402A1 ARP050102489A ARP050102489A AR049402A1 AR 049402 A1 AR049402 A1 AR 049402A1 AR P050102489 A ARP050102489 A AR P050102489A AR P050102489 A ARP050102489 A AR P050102489A AR 049402 A1 AR049402 A1 AR 049402A1
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AR
Argentina
Prior art keywords
mono
groups
alkoxycarbonyl
hydroxycarbonyl
group
Prior art date
Application number
ARP050102489A
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English (en)
Inventor
Ferrer Jordi Gracia
Santacana Lluis Pages
Mol Joan Taltavull
Albero Maria Antonia Buil
Piaz Vittorio Dal
Rubio Yolanda Garrido
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of AR049402A1 publication Critical patent/AR049402A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
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Abstract

Un compuesto de formula (1), en la que R1 representa : un átomo de hidrogeno; un grupo alquilo, alquenilo o alquinilo, que está opcionalmente sustituido con uno o más sustituyentes seleccionados de átomos de halogeno y grupo hidroxi,alcoxi, ariloxi, alquiltio, ariltio, oxo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo o mono- o di-alquilcarbamoilo; R2 representa un grupo heteroarilo monocíclico o policíclico, que está opcionalmente sustituido con uno o más sustituyentes seleccionados de: átomos de halogeno; grupos alquilo y alquileno, que están opcionalmente sustituidos con uno o más sustituyentes seleccionados de átomos de halogeno y grupos fenilo, hidroxi, alcoxi, ariloxi, alquiltio, ariltio, oxo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo o mono- o di-alquilcarbamoilo; grupos fenilo, hidroxi, hidroxicarbonilo, hiidroxialquilo, alcoxicarbonilo, alcoxi, cicloalcoxi, nitro, ciano, ariloxi, alquiltio, ariltio, alquilsulfinilo, alquilsulfonilo, alquilsulfamoilo, acilo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo o mono- o di-alquilcarbamoilo, ureido, N'-alquilureido, N',N'-dialquilureido, alquilsulfamido, aminosulfonilo, mono- o di-alquilaminosulfonilo, ciano, difluorometoxi o trifluorometoxi; R3 representa un átomo de hidrogeno o un grupo alquilcarbonilo en el que el grupo alquilo puede estar sustituido con uno o más sustituyentes seleccionados de átomos de halogeno y grupos fenilo, hidroxi, hidroxialquilo, alcoxi, ariloxi, alquiltio, ariltio, oxo, amino, mono- o di-alquilamino, acilamino, hidroxicarbonilo, alcoxicarbonilo, carbamoilo, mono- o di-alquilcarbamoilo; R4 representa un grupo de formula: G-L1-(CRR')n-, en la que n es un numero entero de 0 a 3; R y R' se seleccionan independientemente del grupo que consiste en átomos de hidrogeno y grupos alquilo inferior; L1 es un fragmento enlazador seleccionado del grupo que consiste en un enlace directo, grupos -O-, -CO-, -NR''-, -O(CO)NR''-, -O(CO)O-, -O-(CO)-, -(CO)O-, -NR''-(CO)- y -O(R''O)(PO)O-, en los que R'' se selecciona del grupo que consiste en átomos de hidrogeno y grupos alquilo inferior; G se selecciona de átomos de hidrogeno y grupos alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, heterociclilo, arilo, arilalquilo y heteroarilo, estando dichos grupos opcionalmente sustituidos con uno o más sustituyentes seleccionados de: átomos de halogeno; grupos alquilo y alquenilo, que están opcionalmente sustituidos con uno o más sustituyentes seleccionados de átomos de halogeno; y grupos hidroxi, alcoxi, cicloalquiloxi, alquiltio, alquilsulfinilo, alquilsulfonilo, alquilsulfamoilo, amino, mono- o di-alquilamino, acilamino, nitro, acilo, hidroxicarbonilo, alcoxicarbonilo, carbamoilo, mono- o di-alquilcarbamoilo, ureido, N'-alquilureido, N'N'-dialquilureido, alquilsulfamido, amonosulfonilo, mono- o di- alquilaminosulfonilo, ciano, diflurometoxi o trifluorometoxi; y sus sales o N-oxidos farmacéuticamente aceptables.
ARP050102489A 2004-06-18 2005-06-17 Derivados de piridazin-3-(2h)-ona AR049402A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200401500A ES2251866B1 (es) 2004-06-18 2004-06-18 Nuevos derivados de piridazin-3(2h)-ona.

Publications (1)

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AR049402A1 true AR049402A1 (es) 2006-07-26

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ARP050102489A AR049402A1 (es) 2004-06-18 2005-06-17 Derivados de piridazin-3-(2h)-ona

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Country Link
US (1) US7960383B2 (es)
EP (1) EP1758869B1 (es)
JP (1) JP2008502628A (es)
KR (1) KR20070029808A (es)
CN (1) CN1964952A (es)
AR (1) AR049402A1 (es)
AT (1) ATE492538T1 (es)
AU (1) AU2005254659A1 (es)
BR (1) BRPI0511383A (es)
CA (1) CA2570170A1 (es)
DE (1) DE602005025478D1 (es)
EC (1) ECSP067058A (es)
ES (2) ES2251866B1 (es)
IL (1) IL179734A0 (es)
MX (1) MXPA06013593A (es)
NO (1) NO20070321L (es)
PE (1) PE20060436A1 (es)
RU (1) RU2376293C2 (es)
SG (1) SG155909A1 (es)
TW (1) TW200612951A (es)
UA (1) UA88472C2 (es)
UY (1) UY28958A1 (es)
WO (1) WO2005123692A1 (es)
ZA (1) ZA200609403B (es)

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