AR048312A1 - Derivados de pirazolil-indolilo en calidad de activadores ppar - Google Patents
Derivados de pirazolil-indolilo en calidad de activadores pparInfo
- Publication number
- AR048312A1 AR048312A1 ARP050100858A ARP050100858A AR048312A1 AR 048312 A1 AR048312 A1 AR 048312A1 AR P050100858 A ARP050100858 A AR P050100858A AR P050100858 A ARP050100858 A AR P050100858A AR 048312 A1 AR048312 A1 AR 048312A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- cycloalkyl
- alkynyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Composiciones farmacéuticas que contienen tales compuestos, un proceso para su obtencion y su utilizacion para el tratamiento y/o prevencion de enfermedades moduladas por agonistas de PPARdelta y/o PPARalfa. Reivindicacion 1: Compuestos de la formula (1), en la que: R1 es hidrogeno o alquilo C1-7; R2 y R3, con independencia entre sí, son hidrogeno, alquilo C1-7 o alcoxi C1-7; R4 y R5, con independencia entre sí, son hidrogeno, alquilo C1-7, cicloalquilo C3-7, halogeno, alcoxiC1-7- alquiloC1-7, alquenilo C2-7, alquinilo C2-7, fluoroalquilo C1-7, ciano-alquiloC1-7 o ciano; R6, R7, R8 y R9, con independencia entre sí, son hidrogeno, alquilo C1-7, cicloalquilo C3-7, halogeno, alcoxiC1-7-alquiloC1-7, alquenilo C2-7, alquinilo C2- 7, fluoroalquilo C1-7, ciano-alquiloC1-7 o ciano; y uno de R6, R7 y R8 es un grupo de formula (2), en la que: R10 es hidrogeno, alquilo C1-7, cicloalquilo C3-7, o fluoralquilo C1-7; R11 es hidrogeno, alquilo C1-7, o alcoxiC1-7-alquiloC1-7; uno de R12 o R13 es hidrogeno, alquilo C1-7, cicloalquilo C3-7, alcoxiC2-7-alquilo1-7, alquenilo C2-7, alquinilo C2-7 o fluoralquilo C1-7; y el otro es un par solitario; R14 es hidrogeno, alquilo C1-7, cicloalquilo C3-7, halogeno, alcoxiC1-7-alquiloC1-7, alquenilo C2-7, alquinilo C2-7 o fluoroalquilo C1-7; R15 es arilo o heteroarilo; y n es 1, 2 o 3; y todos los enantiomeros y sales y/o ésteres farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100958 | 2004-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048312A1 true AR048312A1 (es) | 2006-04-19 |
Family
ID=34917207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100858A AR048312A1 (es) | 2004-03-09 | 2005-03-07 | Derivados de pirazolil-indolilo en calidad de activadores ppar |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7265149B2 (es) |
| EP (1) | EP1725546B1 (es) |
| JP (1) | JP4599395B2 (es) |
| CN (1) | CN100467463C (es) |
| AR (1) | AR048312A1 (es) |
| AT (1) | ATE410422T1 (es) |
| AU (1) | AU2005219536A1 (es) |
| BR (1) | BRPI0509440A (es) |
| CA (1) | CA2557789C (es) |
| DE (1) | DE602005010218D1 (es) |
| ES (1) | ES2314630T3 (es) |
| RU (1) | RU2375357C2 (es) |
| TW (1) | TW200540153A (es) |
| WO (1) | WO2005085235A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405236B2 (en) * | 2004-08-16 | 2008-07-29 | Hoffman-La Roche Inc. | Indole derivatives comprising an acetylene group |
| US8252790B2 (en) | 2008-11-21 | 2012-08-28 | Raqualia Pharma Inc. | Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity |
| CN113480522A (zh) * | 2021-08-19 | 2021-10-08 | 守恒(厦门)医疗科技有限公司 | 新型苯基吡唑类衍生物及其在降血糖药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| CZ2004272A3 (cs) * | 2001-08-29 | 2005-02-16 | Warner-Lambert Company Llc | Perorální antidiabetická činidla |
| US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| WO2003099793A1 (en) * | 2002-05-24 | 2003-12-04 | Takeda Pharmaceutical Company Limited | 1,2-azole derivatives with hypoglycemic and hypolipidemic activity |
| CA2510516A1 (en) | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Fused heterocyclic derivatives as ppar modulators |
-
2005
- 2005-02-28 RU RU2006135544/04A patent/RU2375357C2/ru not_active IP Right Cessation
- 2005-02-28 BR BRPI0509440-2A patent/BRPI0509440A/pt not_active IP Right Cessation
- 2005-02-28 AU AU2005219536A patent/AU2005219536A1/en not_active Abandoned
- 2005-02-28 CN CNB2005800075312A patent/CN100467463C/zh not_active Expired - Fee Related
- 2005-02-28 EP EP05715587A patent/EP1725546B1/en not_active Not-in-force
- 2005-02-28 AT AT05715587T patent/ATE410422T1/de active
- 2005-02-28 DE DE602005010218T patent/DE602005010218D1/de active Active
- 2005-02-28 ES ES05715587T patent/ES2314630T3/es active Active
- 2005-02-28 CA CA2557789A patent/CA2557789C/en not_active Expired - Fee Related
- 2005-02-28 JP JP2007502232A patent/JP4599395B2/ja not_active Expired - Fee Related
- 2005-02-28 WO PCT/EP2005/002074 patent/WO2005085235A1/en active Application Filing
- 2005-03-04 TW TW094106683A patent/TW200540153A/zh unknown
- 2005-03-07 AR ARP050100858A patent/AR048312A1/es unknown
- 2005-03-08 US US11/074,474 patent/US7265149B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1725546A1 (en) | 2006-11-29 |
| RU2375357C2 (ru) | 2009-12-10 |
| RU2006135544A (ru) | 2008-04-20 |
| BRPI0509440A (pt) | 2007-09-04 |
| CA2557789C (en) | 2012-12-11 |
| DE602005010218D1 (de) | 2008-11-20 |
| CN1930150A (zh) | 2007-03-14 |
| US7265149B2 (en) | 2007-09-04 |
| TW200540153A (en) | 2005-12-16 |
| JP2007527880A (ja) | 2007-10-04 |
| CA2557789A1 (en) | 2005-09-15 |
| CN100467463C (zh) | 2009-03-11 |
| ES2314630T3 (es) | 2009-03-16 |
| ATE410422T1 (de) | 2008-10-15 |
| WO2005085235A1 (en) | 2005-09-15 |
| JP4599395B2 (ja) | 2010-12-15 |
| US20050203160A1 (en) | 2005-09-15 |
| EP1725546B1 (en) | 2008-10-08 |
| AU2005219536A1 (en) | 2005-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |