AR047123A1 - Indoles sustituidos de piperidina o heteroderivados de los mismos - Google Patents
Indoles sustituidos de piperidina o heteroderivados de los mismosInfo
- Publication number
- AR047123A1 AR047123A1 ARP040104231A ARP040104231A AR047123A1 AR 047123 A1 AR047123 A1 AR 047123A1 AR P040104231 A ARP040104231 A AR P040104231A AR P040104231 A ARP040104231 A AR P040104231A AR 047123 A1 AR047123 A1 AR 047123A1
- Authority
- AR
- Argentina
- Prior art keywords
- het
- cycloalkyl
- alkyl
- aryl
- halogen
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 2
- 101100533890 Hypocrea jecorina (strain QM6a) sor3 gene Proteins 0.000 abstract 2
- 101100533874 Hypocrea jecorina (strain QM6a) sor5 gene Proteins 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 abstract 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 150000002829 nitrogen Chemical class 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente se refiere a indoles sustituidos de piperidina o heteroderivados de los mismos de la formula (1), en la que: R1 es arilo, het o una especie anelada de los mismos, en el que het es un anillo heterocíclico y las especies aneladas comprenden anelaciones aril-het-, het-aril- o het-het-, cada uno de dichos arilo o het se puede sustituir con uno, dos o tres R2; R2 son cada uno independientemente: alquilo C1-6, cicloalquilo C3-6, haloalquilo C1-6, aralquilo C1-6, halogeno, CN, COOR3, COR3, CONR3R4, NR3R4, NR3SO2R4, OR3, NO2, SR3, SOR3, SO2R3 o SO2NR3R4; R3 es H, alquilo C1-6, cicloalquilo C3-8 o (cicloalquil C3-8)alquilo C1-6; R4 es H, alquilo C1-6, cicloalquilo C3-8 o (cicloalquil C3-8)alquilo C1-6 o R3 y R4 junto con el átomo de nitrogeno interyacente o grupo N-SO2- forman un anillo de 3 a 8 miembros, heterocíclico, que contiene nitrogeno opcionalmente sustituido; R5 es alquilo C1-6, alcoxi C1-6, aciloxi C1-6, aralquilo C1-6, cicloalquilo C3-6, (-cicloalquil C3- 6)alquilo C1-6, haloalquilo C1-6, tioalquilo C1-6, halogeno, NO2, CN; R6 son cada uno independientemente: alquilo C1-6, alcoxi C1-6, aciloxi C1-6, aralquilo C1-6, cicloalquilo C3-6, haloalquilo C1-6, tioalquilo C1-6, halogeno, OR3, SR3, CN, NO2, COOR3, COR3, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, SOR3, SO2R3, SO2NR3R4, arilo o het; A es (cicloalquil C3-6)alquileno C2-8, alquileno C2-8 de cadena lineal o ramificada, opcionalmente sustituido con halogeno u OH; B es arilo o het; D-E es CH-CH2- o C=CH-; X-W-V es N-C=CR7 o C=C-NR7; R7 es H o alquilo C1-6; Y es CF2, NR4, O, S(O)n; i, j son cada uno independientemente 0, 1 o 2, en los que 0 L i+j L 4; n es 0, 1 o 2; m es 0, 1, 2, 3 o 4; y sales farmacéuticas aceptables de los mismos. Método de preparacion de los compuestos de formula (1), composiciones farmacéuticas, uso de los compuestos para la preparacion de un medicamento para el tratamiento de enfermedades en que los moduladores de actividad CCR3 tienen un beneficio terapéutico y método de tratamiento de enfermedades.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03026170 | 2003-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR047123A1 true AR047123A1 (es) | 2006-01-11 |
Family
ID=34610050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104231A AR047123A1 (es) | 2003-11-17 | 2004-11-17 | Indoles sustituidos de piperidina o heteroderivados de los mismos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7544806B2 (es) |
| EP (1) | EP1687294B1 (es) |
| JP (1) | JP4825679B2 (es) |
| KR (1) | KR20060127000A (es) |
| CN (1) | CN1882565A (es) |
| AR (1) | AR047123A1 (es) |
| AU (1) | AU2004291297B2 (es) |
| BR (1) | BRPI0416665A (es) |
| CA (1) | CA2545261C (es) |
| IL (1) | IL175678A (es) |
| MX (1) | MXPA06004626A (es) |
| MY (1) | MY143862A (es) |
| NZ (1) | NZ547314A (es) |
| PE (1) | PE20051007A1 (es) |
| RU (1) | RU2382037C2 (es) |
| TW (1) | TW200526622A (es) |
| UY (1) | UY28618A1 (es) |
| WO (1) | WO2005049559A2 (es) |
| ZA (1) | ZA200601800B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE531706T1 (de) | 2005-04-30 | 2011-11-15 | Boehringer Ingelheim Int | Neue piperidin-substituierte indole und ihre verwendung als ccr-3-modulatoren |
| CA2667547C (en) | 2006-10-27 | 2014-07-29 | Boehringer Ingelheim International Gmbh | Piperidyl-propane-thiol ccr3 modulators |
| US8148403B2 (en) | 2006-10-27 | 2012-04-03 | Boehringer Ingelheim International Gmbh | Substituted piperidyl-propane-thiols |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2533924A1 (fr) * | 1982-10-05 | 1984-04-06 | Roussel Uclaf | Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant |
| US5521197A (en) | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| JP2000516210A (ja) * | 1996-07-12 | 2000-12-05 | ロイコサイト，インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
| US5962473A (en) | 1996-08-16 | 1999-10-05 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F |
| WO1998011895A1 (en) | 1996-09-18 | 1998-03-26 | Eli Lilly And Company | A method for the prevention of migraine |
| AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| EA200000768A1 (ru) | 1998-01-27 | 2001-06-25 | Эвентис Фармасьютикалз Продактс Инк. | ЗАМЕЩЕННЫЕ ОКСОАЗАГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ ФАКТОРА Ха |
| ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| EP1242072A4 (en) | 1999-12-17 | 2004-02-04 | Bristol Myers Squibb Co | ANTIPSYCHOTIC HETEROCYCLIC COMPOUNDS |
| AU2001232319B2 (en) * | 2000-02-18 | 2005-01-13 | Meiji Seika Kaisha, Ltd. | Phenoxyalkylamine derivates useful as opioid delta receptor ligands |
| JP2004504396A (ja) | 2000-07-21 | 2004-02-12 | ハー・ルンドベック・アクチエゼルスカベット | Ｃｎｓ障害の治療に有用なインドール誘導体 |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| ATE531706T1 (de) * | 2005-04-30 | 2011-11-15 | Boehringer Ingelheim Int | Neue piperidin-substituierte indole und ihre verwendung als ccr-3-modulatoren |
-
2004
- 2004-11-11 JP JP2006538792A patent/JP4825679B2/ja not_active Expired - Fee Related
- 2004-11-11 BR BRPI0416665-5A patent/BRPI0416665A/pt not_active IP Right Cessation
- 2004-11-11 KR KR1020067012008A patent/KR20060127000A/ko active IP Right Grant
- 2004-11-11 EP EP04818773.6A patent/EP1687294B1/en not_active Not-in-force
- 2004-11-11 WO PCT/EP2004/012775 patent/WO2005049559A2/en active Application Filing
- 2004-11-11 AU AU2004291297A patent/AU2004291297B2/en not_active Ceased
- 2004-11-11 CA CA2545261A patent/CA2545261C/en not_active Expired - Fee Related
- 2004-11-11 CN CNA2004800338440A patent/CN1882565A/zh active Pending
- 2004-11-11 RU RU2006121328/04A patent/RU2382037C2/ru not_active IP Right Cessation
- 2004-11-11 NZ NZ547314A patent/NZ547314A/xx not_active IP Right Cessation
- 2004-11-11 MX MXPA06004626A patent/MXPA06004626A/es active IP Right Grant
- 2004-11-12 MY MYPI20044731A patent/MY143862A/en unknown
- 2004-11-15 UY UY28618A patent/UY28618A1/es not_active Application Discontinuation
- 2004-11-15 PE PE2004001117A patent/PE20051007A1/es not_active Application Discontinuation
- 2004-11-16 TW TW093135011A patent/TW200526622A/zh unknown
- 2004-11-16 US US10/990,059 patent/US7544806B2/en active Active
- 2004-11-17 AR ARP040104231A patent/AR047123A1/es not_active Application Discontinuation
-
2006
- 2006-03-02 ZA ZA200601800A patent/ZA200601800B/en unknown
- 2006-05-16 IL IL175678A patent/IL175678A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06004626A (es) | 2006-06-27 |
| US7544806B2 (en) | 2009-06-09 |
| CA2545261A1 (en) | 2005-06-02 |
| CN1882565A (zh) | 2006-12-20 |
| EP1687294A2 (en) | 2006-08-09 |
| AU2004291297A1 (en) | 2005-06-02 |
| IL175678A (en) | 2012-08-30 |
| ZA200601800B (en) | 2007-05-30 |
| JP4825679B2 (ja) | 2011-11-30 |
| WO2005049559A3 (en) | 2006-04-13 |
| US20050153979A1 (en) | 2005-07-14 |
| BRPI0416665A (pt) | 2007-01-16 |
| UY28618A1 (es) | 2005-06-30 |
| JP2007511480A (ja) | 2007-05-10 |
| PE20051007A1 (es) | 2005-12-26 |
| RU2382037C2 (ru) | 2010-02-20 |
| KR20060127000A (ko) | 2006-12-11 |
| MY143862A (en) | 2011-07-15 |
| NZ547314A (en) | 2010-02-26 |
| AU2004291297B2 (en) | 2011-06-23 |
| WO2005049559A2 (en) | 2005-06-02 |
| EP1687294B1 (en) | 2014-05-21 |
| IL175678A0 (en) | 2006-09-05 |
| CA2545261C (en) | 2013-07-23 |
| RU2006121328A (ru) | 2008-01-10 |
| TW200526622A (en) | 2005-08-16 |
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