AR045384A1 - Benzoilguanidinas sustituidas con pentafluorosulfanilfenilo, procedimientos para su preparacion, composiciones farmaceuticas que las comprende y su uso - Google Patents
Benzoilguanidinas sustituidas con pentafluorosulfanilfenilo, procedimientos para su preparacion, composiciones farmaceuticas que las comprende y su usoInfo
- Publication number
- AR045384A1 AR045384A1 ARP040103003A ARP040103003A AR045384A1 AR 045384 A1 AR045384 A1 AR 045384A1 AR P040103003 A ARP040103003 A AR P040103003A AR P040103003 A ARP040103003 A AR P040103003A AR 045384 A1 AR045384 A1 AR 045384A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- so2ch3
- substituted
- alkoxy
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente se refiere a benzoilguanidinas sustituidas con pentafluorosulfanilfenilo, estos compuestos son apropiados como medicamentos antiarrítmicos con un componente cardioprotector para la profilaxis del infarto y el tratamiento del infarto y para el tratamiento de la angina pectoris. También inhiben preventivamente los procesos fisiopatológicos asociados con el desarrollo del daño inducido por la isquemia, especialmente en el desencadenamiento de las arritmias cardíacas inducidas por la isquemia. Reivindicación 1: Una benzoilguanidina sustituida con pentafluorosulfanilfenilo de fórmula (1) o (2) en las que los significados son R1 y R1´, independientemente uno de otro, H, alquilo C1-4, alcoxi C1-4, F, Cl, Br, I, -CN, NR5R6, -Oa-(CH2)b-(CF2)c-CF3 o -(SOd)e-(CH2)f-(CF2)g-CF3; r5 y R6, independientemente uno de otro, H, alquilo C1-4, o -CH2-CF3; d 0, 1 o 2; a, b, c, e, f y g, independientemente uno de otro, 0, o 1; R2 y R2´ independientemente uno del otro, H, F, Cl, Br, I, -CN, SO2CH3, alcoxi C1-4, nr5r6, -Oa-(ch2)b-(CF2)b-(CF2)c-CF3, -(SOh)k-(CH2)l-(CF2)m-CF3, alquilo C1-6, cicloalquilo C3-8, en los que 1, 2, 3, o 4 átomos de H pueden estar sustituidos por átomos de f, -(CH2)n-fenilo que está no sustituido o sustituido con 1, 2, o 3 radicales seleccionados del grupo que consiste en F, Cl, Br, I, -Oo-(CH2)p-CF3, alcoxi C1-4, alquilo C1-4 y -SO2CH3, o -(CH2)q-heteroarilo que está no sustituido o sustituido con 1, 2, o 3 radicales seleccionados del grupo que consiste en F, Cl, Br, I, -Or-(CH2)s-CF3, alcoxi C1-4, alquilo C1-4, y -SO2CH3; R5 y R6 independientemente uno de otro, H, alquilo C1-4 o -CH2-CF3;a, b y c, independientemente uno de otro, 0 o 1; h 0, 1 o 2; k 0 o 1; l 0, 12, 2, 3 o 4; m y o, independientemente uno de otro, 0 o 1; p 0, 1, 2 o 3; n 0, 1, 2, 3, o 4; r 0 o 1; s 0, 1, 2 o 3; q 0, 1, 2, 3 o 4; R3 y R3´, independientemente uno de otro, H, F, Cl, Br, i, -CN, -SO2CH3, alquilo C1-6, u -Ot-(CH2)u-CF3; t 0 o 1; u 0, 1, 2 o 3; R4 H, F, Cl, Br, I, -CN, -SO2CH3, NR5R6, -(SOv)w-(CH2)x-(CF2)v-CF3, -Oz-(CH2)aa-(CF2)bb-CF3, alquilo C3-8, en los que 1, 2, 3 o 4 átomos de H pueden estar sustituidos por átomos de F; R5 y R6, independientemente uno de otro, H, alquilo C1-4 o -CH2-CF3; v 0 1, o 2; x 0, 1, 2, 3 o 4; w, y, z, aa y bb, independientemente uno de otro, 0 o 1; o R4 -(CH2)cc-fenilo que está no sustituido o sustituido con 1, 2, o 3 radicales seleccionados del grupo que consiste en F, Cl, Br, I, -Odd-(CH2)ee-CF3, alcoxi C1-4, alquilo C1-4 y -SO2CH3; dd 0 o 1; ee 0, 1, 2 o 3; cc 0, 1, 2, 3 o 4; o R4 -(CH2)ff-heteroarilo que está no sustituido o sustituido con 1, 2 o 3 radicales seleccionados del grupo que consiste en F, Cl, Br, I, -Ogg-(CH2)hh-CF3, alcoxi C1-4, alquilo C1-4 y -SO2CH3; gg 0 o 1; hh 0, 1, 2 o 3; ff 0, 1, 2, 3 o 4; X una unión directa, O, NR7, S(O)kk; R7 h, alquilo C1-4, -(CH2)mm-CF3 o -SO2CH3; kk 0, 1 o 2; mm 0, 1, 2 o 3; donde -Oa-(CH2)b-(CF2)c-CF3 en las definiciones de R1 y R1´y R2 y R2´ se puede seleccionar independientemente uno de otro, donde NR5R6 en las definiciones de 1 y R1´, R2 y R2´y R4 se puede seleccionar independientemente uno de otro, y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10338554A DE10338554A1 (de) | 2003-08-22 | 2003-08-22 | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045384A1 true AR045384A1 (es) | 2005-10-26 |
Family
ID=34223114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040103003A AR045384A1 (es) | 2003-08-22 | 2004-08-20 | Benzoilguanidinas sustituidas con pentafluorosulfanilfenilo, procedimientos para su preparacion, composiciones farmaceuticas que las comprende y su uso |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1658266B1 (es) |
JP (1) | JP4516965B2 (es) |
AR (1) | AR045384A1 (es) |
AT (1) | ATE477239T1 (es) |
AU (1) | AU2004268762B2 (es) |
BR (1) | BRPI0413798A (es) |
CA (1) | CA2536459A1 (es) |
DE (2) | DE10338554A1 (es) |
IL (1) | IL173546A0 (es) |
MX (1) | MXPA06001466A (es) |
MY (1) | MY140691A (es) |
PE (1) | PE20050279A1 (es) |
TW (1) | TW200524850A (es) |
WO (1) | WO2005021492A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA13285A (en) * | 2003-11-13 | 2007-01-31 | Sanofi Aventis Deutschland | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same. |
JP5418226B2 (ja) * | 2007-08-28 | 2014-02-19 | 宇部興産株式会社 | ペンタフルオロスルファニルベンゼン化合物の製造方法、及び新規なペンタフルオロスルファニルベンゼン化合物 |
US9682931B2 (en) | 2013-11-01 | 2017-06-20 | Ube Industries, Ltd. | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof |
ES2894657T3 (es) * | 2017-07-04 | 2022-02-15 | Sanofi Sa | Compuestos de etinilo, su preparación y su uso terapéutico para el tratamiento de la malaria |
KR102668895B1 (ko) * | 2018-10-30 | 2024-05-23 | 스미토모 고무 코교 카부시키카이샤 | 골프공 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE59305042D1 (de) * | 1992-09-22 | 1997-02-20 | Hoechst Ag | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika |
DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4432101A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0723956B1 (de) * | 1995-01-30 | 1999-10-13 | Hoechst Aktiengesellschaft | Basisch-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
JPH10237077A (ja) * | 1997-02-26 | 1998-09-08 | Yamanouchi Pharmaceut Co Ltd | ヘテロアリール置換プロピオニルグアニジン誘導体 |
DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10024319A1 (de) * | 2000-05-17 | 2001-11-22 | Merck Patent Gmbh | Bisacylguanidine |
DE10222192A1 (de) * | 2002-05-18 | 2003-11-27 | Aventis Pharma Gmbh | Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10226462A1 (de) * | 2002-06-13 | 2003-12-24 | Aventis Pharma Gmbh | Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
-
2003
- 2003-08-22 DE DE10338554A patent/DE10338554A1/de not_active Withdrawn
-
2004
- 2004-08-02 PE PE2004000732A patent/PE20050279A1/es not_active Application Discontinuation
- 2004-08-12 AT AT04764024T patent/ATE477239T1/de not_active IP Right Cessation
- 2004-08-12 AU AU2004268762A patent/AU2004268762B2/en not_active Ceased
- 2004-08-12 WO PCT/EP2004/009020 patent/WO2005021492A1/de active Application Filing
- 2004-08-12 MX MXPA06001466A patent/MXPA06001466A/es active IP Right Grant
- 2004-08-12 CA CA002536459A patent/CA2536459A1/en not_active Abandoned
- 2004-08-12 JP JP2006523580A patent/JP4516965B2/ja not_active Expired - Fee Related
- 2004-08-12 BR BRPI0413798-1A patent/BRPI0413798A/pt not_active IP Right Cessation
- 2004-08-12 EP EP04764024A patent/EP1658266B1/de not_active Expired - Lifetime
- 2004-08-12 DE DE502004011523T patent/DE502004011523D1/de not_active Expired - Lifetime
- 2004-08-19 TW TW093124904A patent/TW200524850A/zh unknown
- 2004-08-20 MY MYPI20043429A patent/MY140691A/en unknown
- 2004-08-20 AR ARP040103003A patent/AR045384A1/es not_active Application Discontinuation
-
2006
- 2006-02-05 IL IL173546A patent/IL173546A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MY140691A (en) | 2010-01-15 |
TW200524850A (en) | 2005-08-01 |
IL173546A0 (en) | 2006-07-05 |
AU2004268762A1 (en) | 2005-03-10 |
EP1658266A1 (de) | 2006-05-24 |
DE10338554A1 (de) | 2005-03-31 |
AU2004268762B2 (en) | 2009-06-25 |
MXPA06001466A (es) | 2006-05-15 |
JP4516965B2 (ja) | 2010-08-04 |
WO2005021492A1 (de) | 2005-03-10 |
CA2536459A1 (en) | 2005-03-10 |
JP2007503378A (ja) | 2007-02-22 |
ATE477239T1 (de) | 2010-08-15 |
PE20050279A1 (es) | 2005-06-01 |
DE502004011523D1 (de) | 2010-09-23 |
EP1658266B1 (de) | 2010-08-11 |
BRPI0413798A (pt) | 2006-10-31 |
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