AR044843A1 - Mejoras en la produccion de virus - Google Patents
Mejoras en la produccion de virusInfo
- Publication number
- AR044843A1 AR044843A1 ARP040102154A ARP040102154A AR044843A1 AR 044843 A1 AR044843 A1 AR 044843A1 AR P040102154 A ARP040102154 A AR P040102154A AR P040102154 A ARP040102154 A AR P040102154A AR 044843 A1 AR044843 A1 AR 044843A1
- Authority
- AR
- Argentina
- Prior art keywords
- virus
- virus production
- residues
- allantoic fluid
- viruses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Un proceso mejorado para recuperar virus de fluido alantoico de embriones de aves infectados con virus. Los virus asociados con residuos granulares y fibrosos en el fluido alantoico se pueden disociar de los residuos y ser recuperados, disminuyendo así el rendimiento viral. La disociación se puede lograr sometiendo al complejo virus-residuos a condiciones de concentraciones elevadas de sal, por ejemplo 0,5 M o más.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47972303P | 2003-06-20 | 2003-06-20 | |
US54078204P | 2004-01-30 | 2004-01-30 | |
US57271804P | 2004-05-20 | 2004-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR044843A1 true AR044843A1 (es) | 2005-10-05 |
Family
ID=33545338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102154A AR044843A1 (es) | 2003-06-20 | 2004-06-22 | Mejoras en la produccion de virus |
Country Status (10)
Country | Link |
---|---|
US (2) | US7270990B2 (es) |
EP (1) | EP1636352B1 (es) |
JP (1) | JP4558652B2 (es) |
AR (1) | AR044843A1 (es) |
AT (1) | ATE478137T1 (es) |
AU (1) | AU2004249802B2 (es) |
CA (1) | CA2503774C (es) |
DE (1) | DE602004028736D1 (es) |
MX (1) | MXPA05005306A (es) |
WO (1) | WO2004113518A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200634145A (en) * | 2005-01-25 | 2006-10-01 | Wyeth Res Ireland Ltd | Shear protectants in harvest microfiltration |
EP2102656B1 (en) * | 2006-08-18 | 2013-09-25 | Huiru Wang | A process for identification of molecular mimicry and the uses thereof |
CN102170902B (zh) * | 2008-08-01 | 2015-07-15 | 伽玛疫苗有限公司 | 流感疫苗 |
WO2010079081A1 (en) * | 2009-01-07 | 2010-07-15 | Glaxosmithkline Biologicals S.A. | Methods for recovering a virus or a viral antigen produced by cell culture |
WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
AU2012211043B2 (en) | 2011-01-27 | 2017-04-06 | Gamma Vaccines Pty Limited | Combination vaccines |
EP3013947B1 (en) * | 2013-06-28 | 2018-10-24 | IntelliCyt Corporation | Processing biological material for flow cytometry evaluation for virus particles |
CN105505889A (zh) * | 2015-12-24 | 2016-04-20 | 华南农业大学 | 一种禽流感病毒纯化的方法 |
US10626376B2 (en) | 2016-11-14 | 2020-04-21 | St. Jude Children's Research Hospital | Method for isolating and purifying adeno-associated virus particles using salt |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB660109A (en) * | 1946-10-01 | 1951-10-31 | American Cyanamid Co | Improvements in or relating to the treatment of allantoic fluid containing a propagated virus together with non-viral proteins to obtain the virus in purified and viable from for use in a vaccine |
US3105012A (en) * | 1961-10-19 | 1963-09-24 | Parke Davis & Co | Antigen products and means for producing the same |
US3316153A (en) * | 1965-03-29 | 1967-04-25 | Lilly Co Eli | Virus purification |
AU405949B1 (en) | 1966-02-24 | 1970-09-18 | The Australian National University | Influenza virus sub-unit vaccine |
GB1214135A (en) * | 1967-02-21 | 1970-12-02 | Wellcome Found | Vaccines |
US3627873A (en) * | 1967-06-09 | 1971-12-14 | Arden Wesley Moyer | Influenza vaccine with reduced pyrogenicity |
US3470067A (en) * | 1967-09-19 | 1969-09-30 | Pfizer & Co C | Concentration and purification of viruses from particulate magnetic iron oxide-virus complexes |
FR1604134A (es) * | 1967-09-26 | 1971-07-12 | ||
US3547779A (en) * | 1968-12-18 | 1970-12-15 | Merck & Co Inc | Process for producing purified concentrated influenza virus |
US3870598A (en) * | 1971-04-01 | 1975-03-11 | Alexandra Konstantino Alexeeva | Influenzal vaccine for peroral administration and a method of producing same |
US4206287A (en) * | 1972-07-21 | 1980-06-03 | Agence Nationale De Valorisation De La Recherche (Anvar) | Vaccines and their preparation |
US3919044A (en) * | 1973-03-28 | 1975-11-11 | Armour Pharma | Processes for concentrating and purifying viruses and viral antigens |
US3962421A (en) * | 1973-06-18 | 1976-06-08 | American Home Products Corporation | Method for the disruption of lipid-containing viruses |
US3874999A (en) * | 1973-10-31 | 1975-04-01 | American Cyanamid Co | Process for the purification of virus vaccine |
US4000257A (en) * | 1975-12-22 | 1976-12-28 | American Cyanamid Company | Process for the purification of influenza virus vaccine |
SE420977B (sv) * | 1976-03-18 | 1981-11-16 | Kabi Ab | Forfarande for rening och isolering av hepatitvirus for vaccinframstellning |
US4057626A (en) * | 1976-10-08 | 1977-11-08 | Richardson-Merrell Inc. | Process for detoxifying influenza B virus |
US4500513A (en) * | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
US4338296A (en) * | 1979-10-16 | 1982-07-06 | Smithkline-Rit | Influenza virus and process of producing a vaccine therefrom |
DE3014189A1 (de) * | 1980-04-14 | 1981-10-15 | Europäisches Laboratorium für Molekularbiologie (EMBL), 6900 Heidelberg | Verfahren zur herstellung eines immunogenen membranproteinaggregats von influenza-, parainfluenza- und rhabdo-viren |
US4327182A (en) * | 1981-01-22 | 1982-04-27 | Connaught Laboratories Incorporated | Purification of influenza sub-unit vaccine |
FR2505657A1 (fr) * | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
JPS6147186A (ja) * | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | インフルエンザウイルスの精製方法 |
US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
US4808518A (en) * | 1985-02-11 | 1989-02-28 | University Of Tennessee Research Corporation | Recovery of cytomegalovirus antigen and use thereof in an assay |
US4762939A (en) * | 1987-09-30 | 1988-08-09 | Union Carbide Corporation | Process for trialkoxysilane/tetraalkoxysilane mixtures from silicon metal and alcohol |
US5506129A (en) * | 1991-05-24 | 1996-04-09 | Evans Medical Limited | Virus production |
US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
SE9500724D0 (sv) * | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
FR2723740B1 (fr) * | 1994-08-16 | 1996-11-08 | Pasteur Merieux Serums Vacc | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
US6146873A (en) * | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
US5698433A (en) * | 1994-11-10 | 1997-12-16 | Immuno Ag | Method for producing influenza virus and vaccine |
FR2737730B1 (fr) * | 1995-08-10 | 1997-09-05 | Pasteur Merieux Serums Vacc | Procede de purification de virus par chromatographie |
WO1997025415A1 (de) | 1996-01-05 | 1997-07-17 | Cesa, Clean Energy S.A. | Verfahren zur deaktivierung der hiv und anderer viren |
DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
EP0848956A1 (en) * | 1996-12-17 | 1998-06-24 | Dimminaco Ag/Sa/Ltd. | In ovo vaccination against Newcastle Disease |
GB9705740D0 (en) | 1997-03-20 | 1997-05-07 | Medeva Europ Ltd | A method of preservation |
TW570803B (en) * | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
GB9716611D0 (en) * | 1997-08-07 | 1997-10-08 | Cantab Pharmaceuticals Res Ltd | Virus preparations and methods |
US6210683B1 (en) * | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
ATE371372T1 (de) | 1997-10-09 | 2007-09-15 | Wellstat Biologics Corp | Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren |
US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
KR100281676B1 (ko) | 1997-11-29 | 2001-04-02 | 신동권 | 신규한독감생백신바이러스 |
GB9804632D0 (en) * | 1998-03-05 | 1998-04-29 | Cantab Pharma Res | Virus preparations and methods |
EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
US6579528B1 (en) * | 1998-08-13 | 2003-06-17 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
AT408615B (de) | 1998-09-15 | 2002-01-25 | Immuno Ag | Neue influenzavirus-impfstoffzusammensetzung |
AU4246900A (en) | 1999-04-15 | 2000-11-02 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
CA2418939A1 (en) | 2000-08-07 | 2002-02-14 | Aventis Pasteur Limited | Stabilization of immunogens derived from paramyxoviruses |
JP5063852B2 (ja) | 2000-09-25 | 2012-10-31 | ポリマン サイエンティフィック イミューンバイオロジッシュ フォーシュング ゲゼルシャフト ミット ベシュレンクテル ファフツング | 生ワクチン及び製造方法 |
GB0024089D0 (en) | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
JP2004536785A (ja) | 2001-02-23 | 2004-12-09 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規なワクチン |
WO2002087494A2 (en) | 2001-04-27 | 2002-11-07 | Glaxosmithkline Biologicals, Sa | Novel vaccine |
US7033813B2 (en) * | 2001-09-05 | 2006-04-25 | Trevor P Castor | Inactivated vaccines for aids and other infectious diseases |
DE60327069D1 (de) * | 2002-04-30 | 2009-05-20 | Oncolytics Biotech Inc | Verbesserte reinigungsmethode für viren |
-
2004
- 2004-06-18 JP JP2005518242A patent/JP4558652B2/ja not_active Expired - Fee Related
- 2004-06-18 MX MXPA05005306A patent/MXPA05005306A/es active IP Right Grant
- 2004-06-18 EP EP04737840A patent/EP1636352B1/en not_active Expired - Lifetime
- 2004-06-18 DE DE602004028736T patent/DE602004028736D1/de not_active Expired - Lifetime
- 2004-06-18 AU AU2004249802A patent/AU2004249802B2/en not_active Ceased
- 2004-06-18 AT AT04737840T patent/ATE478137T1/de not_active IP Right Cessation
- 2004-06-18 WO PCT/CA2004/000901 patent/WO2004113518A1/en active IP Right Grant
- 2004-06-18 CA CA002503774A patent/CA2503774C/en not_active Expired - Fee Related
- 2004-06-18 US US10/871,768 patent/US7270990B2/en not_active Expired - Fee Related
- 2004-06-22 AR ARP040102154A patent/AR044843A1/es active IP Right Grant
-
2007
- 2007-09-17 US US11/856,417 patent/US20090035837A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA05005306A (es) | 2005-10-26 |
JP2006511240A (ja) | 2006-04-06 |
CA2503774C (en) | 2007-09-25 |
US20090035837A1 (en) | 2009-02-05 |
EP1636352B1 (en) | 2010-08-18 |
ATE478137T1 (de) | 2010-09-15 |
US7270990B2 (en) | 2007-09-18 |
AU2004249802B2 (en) | 2007-06-28 |
AU2004249802A1 (en) | 2004-12-29 |
WO2004113518A1 (en) | 2004-12-29 |
EP1636352A1 (en) | 2006-03-22 |
JP4558652B2 (ja) | 2010-10-06 |
US20050186223A1 (en) | 2005-08-25 |
CA2503774A1 (en) | 2004-12-29 |
DE602004028736D1 (de) | 2010-09-30 |
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Legal Events
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