AR044801A1 - Sales de aminas del acido (2s)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico - Google Patents

Sales de aminas del acido (2s)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico

Info

Publication number
AR044801A1
AR044801A1 ARP040102111A ARP040102111A AR044801A1 AR 044801 A1 AR044801 A1 AR 044801A1 AR P040102111 A ARP040102111 A AR P040102111A AR P040102111 A ARP040102111 A AR P040102111A AR 044801 A1 AR044801 A1 AR 044801A1
Authority
AR
Argentina
Prior art keywords
phenylethyl
amino
phenyl
ethoxy
hexyl
Prior art date
Application number
ARP040102111A
Other languages
English (en)
Inventor
Carl Johan Aurell
Mikael Dahistrom
Anna Minidis
Bengt Ohissori
Erica Stahle
Alstermark Eva-Lotte Lindstedt
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR044801A1 publication Critical patent/AR044801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto seleccionado entre uno o más de los siguientes: una sal (1R,2S)-2-hidroxiindan-1-amina de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico; una sal de L-arginina de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino-2-oxoetoxifenil)propanoico; una sal de tert-butilamina de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino-2-oxoetoxifenil)propanoico; una sal de colina de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico; una sal de adamantilamina de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico; una sal de N-bencil2-feniletanaminio de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico; una sal de N-bencil-2-(bencilamino)etanaminio de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico; o una sal de tris(hidroximetil)metilamina de ácido (2S)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico. Sus solvato, hidrato, solvato/hidratomixto, forma no solvatada o no hidratada.
ARP040102111A 2003-06-18 2004-06-17 Sales de aminas del acido (2s)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico AR044801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0314129.8A GB0314129D0 (en) 2003-06-18 2003-06-18 Therapeutic agents

Publications (1)

Publication Number Publication Date
AR044801A1 true AR044801A1 (es) 2005-10-05

Family

ID=27636788

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040102111A AR044801A1 (es) 2003-06-18 2004-06-17 Sales de aminas del acido (2s)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico

Country Status (23)

Country Link
US (1) US20060142389A1 (es)
EP (1) EP1638922A1 (es)
JP (1) JP3822900B1 (es)
KR (1) KR20060027348A (es)
CN (1) CN1809529A (es)
AR (1) AR044801A1 (es)
AU (1) AU2004247610B2 (es)
BR (1) BRPI0411525A (es)
CA (1) CA2528932A1 (es)
CO (1) CO5650228A2 (es)
GB (1) GB0314129D0 (es)
IL (1) IL172167A0 (es)
IS (1) IS8231A (es)
MX (1) MXPA05013714A (es)
MY (1) MY137277A (es)
NO (1) NO20055922L (es)
RU (1) RU2005138590A (es)
SA (1) SA04250169B1 (es)
TW (1) TW200503677A (es)
UA (1) UA81807C2 (es)
UY (1) UY28375A1 (es)
WO (1) WO2004110984A1 (es)
ZA (1) ZA200510252B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0314079D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
GB0229931D0 (en) * 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
SE0104334D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
DK1517883T3 (da) 2002-06-20 2008-05-26 Astrazeneca Ab Ortho-substituerede benzoesyrederivater til behandling af insulinresistens
SE0403072D0 (sv) * 2004-12-16 2004-12-16 Astrazeneca Ab Pharmaceutically useful salts of carboxylic acid derivates
WO2007004957A1 (en) * 2005-07-05 2007-01-11 Astrazeneca Ab Novel crystalline form
AR055073A1 (es) * 2005-07-11 2007-08-01 Astrazeneca Ab Agentes terapeuticos
NO2686520T3 (es) 2011-06-06 2018-03-17
US8865748B2 (en) 2011-06-06 2014-10-21 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
NZ714963A (en) 2013-06-13 2020-07-31 Akebia Therapeutics Inc Compositions and methods for treating anemia
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
NZ773901A (en) 2015-04-01 2024-07-26 Akebia Therapeutics Inc Compositions and methods for treating anemia
AU2019265629B2 (en) 2018-05-09 2024-09-12 Akebia Therapeutics, Inc. Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL351898A1 (en) * 1999-04-06 2003-06-30 Sankyo Co O-substituted derivatives of carboxylic acids
SE0104334D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date
WO2004110984A1 (en) 2004-12-23
GB0314129D0 (en) 2003-07-23
TW200503677A (en) 2005-02-01
IS8231A (is) 2006-01-13
AU2004247610B2 (en) 2008-04-17
US20060142389A1 (en) 2006-06-29
EP1638922A1 (en) 2006-03-29
SA04250169A (ar) 2005-12-03
AU2004247610A1 (en) 2004-12-23
SA04250169B1 (ar) 2007-08-07
MXPA05013714A (es) 2006-06-27
IL172167A0 (en) 2009-02-11
ZA200510252B (en) 2006-12-27
KR20060027348A (ko) 2006-03-27
JP3822900B1 (ja) 2006-09-20
CO5650228A2 (es) 2006-06-30
MY137277A (en) 2009-01-30
BRPI0411525A (pt) 2006-08-01
UA81807C2 (uk) 2008-02-11
UY28375A1 (es) 2005-01-31
CN1809529A (zh) 2006-07-26
JP2006527766A (ja) 2006-12-07
RU2005138590A (ru) 2006-07-27
CA2528932A1 (en) 2004-12-23
NO20055922L (no) 2006-01-06

Similar Documents

Publication Publication Date Title
AR044801A1 (es) Sales de aminas del acido (2s)-2-etoxi-3-(4-{2-[hexil(2-feniletil)amino]-2-oxoetoxi}fenil)propanoico
GT200500257AA (es) Procedimiento para producir derivados de amina opticamente activos
AR068479A1 (es) (carboxilalquilenfenil) feniloxamidas, procedimiento para su preparacion y una coomposicion farmaceutica
AR116951A1 (es) Sales cristalinas de un inhibidor de calicreína plasmática
CO2018005941A2 (es) Formas sólidas de éster etílico del ácido (2r,4s)-5-(bifenil-4-il)-4-[(3-carboxipropionil)amino]-2-metil-pentanoico, sus sales y un método de preparación
RS54445B1 (en) 3,5-DIAMINO-6-CHLORO-N- (N- (4- (4- (2- (HEXYL (2,3,4,5,6-PENTAHYDROXYHEXYL) AMINO) ETHOXY) PHENYL) BUTYL) CARBAMIMIDOIL) PYRAZINE -2-CARBOXAMIDE
AR042632A1 (es) Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas
CO6630136A2 (es) Procedimiento para la preparación de 4-{4[({4-cloro-3-(trifluorometil) fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridina-2-carbocamida, sus sales y su monohidrato
ATE540051T1 (de) Age-inhibitoren
GT200300010A (es) Esteres hidroxamato del acido n-(4-fenil sustituido)-antranilico
ATE519737T1 (de) Organische verbindungen
AR077080A1 (es) Compuestos de 2,3-dihidro-1h-indeno
AR068056A1 (es) Derivados de n, n'-2, 4 - dianilinopirimidinas, su preparacion, su uso como medicamentos, composiciones farmaceuticas y especialmente como inhibidores de ikk.
ES2634683T3 (es) Método de preparación de cisteína o de un derivado de la misma utilizando una nueva O-fosfoserina sulfhidrilasa
CL2018001067A1 (es) Compuesto piranodipiridínico.
ES2524972T3 (es) Método y sustancias para la preparación de compuestos de piridinio N-sustituidos
ES2542615T3 (es) Sustratos para detección cromogénica y métodos de uso en los ensayos y kits de detección
AR104935A1 (es) Formas cristalinas de un inhibidor de histona deacetilasa
UY27236A1 (es) Inhibidores de pcp basados en ácidos 3-heterociclilpropanohidroxámicos
BR112012033030A2 (pt) composição herbicida de sais de ácido picolínico
CR20130158A (es) Derivados de 1,4-oxazepina
DK1660471T3 (da) Derivater af hydroxamsyre som metalloproteinaseinhibitorer
AR055006A1 (es) Sales farmaceuticamente utiles de derivados de acido carboxilico
AR044267A1 (es) Compuesto intermedio util para la preparacion de pioglitazona
AR078258A1 (es) Derivados de 5,6,7,8-tetrahidroindolizina como inhibidores de hsp90, composiciones que los contienen y utilizacion

Legal Events

Date Code Title Description
FA Abandonment or withdrawal