AR044666A1 - Derivados benzoimidazolicos, composiciones que los contienen, su preparacion y usos de los mismos. - Google Patents
Derivados benzoimidazolicos, composiciones que los contienen, su preparacion y usos de los mismos.Info
- Publication number
- AR044666A1 AR044666A1 ARP040102017A ARP040102017A AR044666A1 AR 044666 A1 AR044666 A1 AR 044666A1 AR P040102017 A ARP040102017 A AR P040102017A AR P040102017 A ARP040102017 A AR P040102017A AR 044666 A1 AR044666 A1 AR 044666A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- cycloalkyl
- cycloalkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a derivados benzoimidazólicos, composiciones farmacéuticas que incluyen los compuestos. Estos son útiles en terapia, particularmente en el manejo del dolor. Reivindicación 1: Un compuesto de fórmula (1) o su sal aceptable para uso farmacéutico del mismo: en el cual Z se selecciona de O= y S=; R1 se selecciona de alquilo C1-10, alquenilo C2-10, alquinilo C2-10, R5R6N-alquilo C1-6, R5O-alquilo C1-6, R5C(=O)N(-R6)-alquilo C1-6, R5R6NS(=O)2-alquilo C1-6, R5CS(=O)2N(-R6)- alquilo C1-6, R5R6NC(=O)N(-R7)-alquilo C1-6, R5R6NS(=O)2N(R7)-alquilo C1-6, aril-C6-10-alquilo C1-6, aril-C6-10-C(=O)-alquilo C1-6, cicloalquil-C3-10-alquilo C1-6, cicloalquenil-C4-8-alquilo C1-6, heterociclil-C3-6-alquilo C1-6, heterociclil-C3-6- C(=O)-alquilo C1-6, hidrocarbilamino C1-10, R5R6N-, R5O-, R5C(=O)N(-R6)-, R5R6NS(=O)2-, R5CS(=O)2N(-R6)-, R5R6NC(=O)N(-R7)-, R5R6NS(=O)2N(R7)-, arilo C6-10, aril-C6-10-C(=O)-, cicloalquilo C3-10, cicloalquenilo C4-8, heterociclilo C3-6 y heterociclil-C3-6-C(=O)-, donde dicho alquilo C1-10, alquenilo C2-10, alquinilo C2-10, aril-C6-10-alquilo C1-6, aril-C6-10-C(=O)-alquilo C1-6, cicloalquil-C3-10-alquilo C1-6, cicloalquenil-C4-8-alquilo C1-6, heterociclil-C3-6-alquilo C1-6, heterociclil-C3-6-C(=O)-alquilo C1-6, hidrocarbilamino C1-10, arilo C6-10, aril-C6-10-C(=O)-, cicloalquilo C3-10, cicloalquenilo C4-8, heterociclilo C3-6 o heterociclil-C3-6-C(=O)- usado para definir R1 está sustituido opcionalmente con uno o más grupos seleccionados de halógeno, ciano, nitro, metoxi, etoxi, metilo, etilo, hidroxi y -NR5R6; R2 se selecciona del grupo conformado por alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-10, cicloalquil-C3-10-alquilo C1-6, cicloalquenil-C4-8-alquilo C1-6, heterocicloalquil-C3-6-alquilo C1-6, cicloalquenilo C4-8, R5R6N-, heteroarilo C3-5, arilo C6-10 y heterocicloalquil C3-6, donde dicho alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-8, cicloalquil-C3- 8-alquilo C1-6, cicloalquenil-C4-8-alquilo C1-6, heterocicloalquil-C3-6-alquilo C1-6, cicloalquenilo C4-8, heteroarilo C3-5, arilo C6-10 o heterocicloalquil C3-6 usado para definir R2 está sustituido opcionalmente con uno o más grupos seleccionados de halógeno, ciano, nitro, metoxi, etoxi, metilo, etilo, hidroxi y -NR5R6; donde R5, R6 y R7 se seleccionan independientemente de -H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, y un grupo de C1-6 divalente que junto con otro R5, R6 o R7 divalente forma una porción de un anillo; y R3 se selecciona independientemente R8 y RO- y R8R9N-; cada uno de R4, R8 y R9 se selecciona independientemente de -H, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-10, cicloalquil-C3-10-alquilo C1-6, heterociclilo C3-6, arilo C6-10, heterociclil-C3-6-alquilo C1-6, aril-C6-10-alquilo C1-6 y un grupo C1-6 divalente que junto con otro divalente seleccionado de R4, R8 y R9 forma una porción de un anillo, donde dicho alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-10, cicloalquil-C3-10-alquilo C1-6, heterociclilo C3-6, arilo C6-10, heterociclil-C3-6-alquilo C1-6, aril-C6-10-alquilo C1-6, o grupo C1-6 divalente está sustituido opcionalmente con uno o más grupos seleccionados de halógeno, ciano, nitro, metoxi, etoxi, metilo, etilo, hidroxi y amino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0301701A SE0301701D0 (sv) | 2003-06-10 | 2003-06-10 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044666A1 true AR044666A1 (es) | 2005-09-21 |
Family
ID=29212435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102017A AR044666A1 (es) | 2003-06-10 | 2004-06-10 | Derivados benzoimidazolicos, composiciones que los contienen, su preparacion y usos de los mismos. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7501447B2 (es) |
| EP (1) | EP1636214A1 (es) |
| JP (1) | JP2006527249A (es) |
| KR (1) | KR20060018258A (es) |
| CN (1) | CN100455580C (es) |
| AR (1) | AR044666A1 (es) |
| AU (1) | AU2004245298A1 (es) |
| BR (1) | BRPI0411246A (es) |
| CA (1) | CA2528925A1 (es) |
| CO (1) | CO5660260A2 (es) |
| IL (1) | IL172023A0 (es) |
| IS (1) | IS8219A (es) |
| NO (1) | NO20060147L (es) |
| RU (1) | RU2005138366A (es) |
| SE (1) | SE0301701D0 (es) |
| TW (1) | TW200504029A (es) |
| UY (1) | UY28356A1 (es) |
| WO (1) | WO2004108712A1 (es) |
| ZA (1) | ZA200509863B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301446D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| SE0302573D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302570D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| CN101031563A (zh) * | 2004-09-24 | 2007-09-05 | 阿斯利康(瑞典)有限公司 | 苯并咪唑衍生物、含有它们的组合物、其制备方法和用途 |
| EP1797078A4 (en) * | 2004-09-24 | 2009-04-01 | Astrazeneca Ab | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THESE DERIVATIVES, PREPARATION AND USES THEREOF |
| EP1797077B1 (en) * | 2004-09-24 | 2012-02-15 | AstraZeneca AB | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i |
| ES2380709T3 (es) | 2004-09-24 | 2012-05-17 | Astrazeneca Ab | Derivados de bencimidazol, composiciones que los contienen, su preparación y usos |
| WO2006033629A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Benzimidazole derivatives and their use as cannabinoid receptor ligands |
| WO2006033628A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| WO2006033632A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Benzimidazole derivatives and their use as cannabinoid receptor ligands I |
| EP1807398B1 (en) | 2004-10-27 | 2008-06-25 | F. Hoffmann-Roche AG | New indole or benzimidazole derivatives |
| WO2007024294A2 (en) * | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| UY30048A1 (es) * | 2005-12-23 | 2007-07-31 | Astrazeneca Ab | Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| TWI433839B (zh) * | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| ES2749103T3 (es) | 2014-09-12 | 2020-03-19 | Knopp Biosciences Llc | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| JP2021518844A (ja) | 2018-03-19 | 2021-08-05 | ノップ バイオサイエンシーズ エルエルシー | Ｋｖ７チャネル活性化剤の構成および使用方法 |
| KR20230131133A (ko) * | 2022-03-04 | 2023-09-12 | 삼진제약주식회사 | 신규한 헤테로 고리 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793718A (fr) | 1972-01-07 | 1973-07-05 | Merck & Co Inc | Aminobenzimidazoles |
| CN1211238A (zh) * | 1995-12-28 | 1999-03-17 | 藤泽药品工业株式会社 | 苯并咪唑衍生物 |
| JP2000095767A (ja) * | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | 性腺刺激ホルモン放出ホルモン拮抗剤 |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| SE0101387D0 (sv) | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
| TWI231757B (en) | 2001-09-21 | 2005-05-01 | Solvay Pharm Bv | 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
| SE0203070D0 (en) * | 2002-10-16 | 2002-10-16 | Astrazeneca Ab | Novel compounds |
| SE0301698D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
-
2003
- 2003-06-10 SE SE0301701A patent/SE0301701D0/xx unknown
-
2004
- 2004-06-09 WO PCT/GB2004/002430 patent/WO2004108712A1/en active Application Filing
- 2004-06-09 EP EP04736412A patent/EP1636214A1/en not_active Withdrawn
- 2004-06-09 BR BRPI0411246-6A patent/BRPI0411246A/pt not_active IP Right Cessation
- 2004-06-09 KR KR1020057023713A patent/KR20060018258A/ko not_active Application Discontinuation
- 2004-06-09 CA CA002528925A patent/CA2528925A1/en not_active Abandoned
- 2004-06-09 US US10/557,806 patent/US7501447B2/en not_active Expired - Fee Related
- 2004-06-09 CN CNB2004800163234A patent/CN100455580C/zh not_active Expired - Fee Related
- 2004-06-09 AU AU2004245298A patent/AU2004245298A1/en not_active Abandoned
- 2004-06-09 JP JP2006516386A patent/JP2006527249A/ja active Pending
- 2004-06-09 RU RU2005138366/04A patent/RU2005138366A/ru not_active Application Discontinuation
- 2004-06-10 TW TW093116689A patent/TW200504029A/zh unknown
- 2004-06-10 AR ARP040102017A patent/AR044666A1/es not_active Application Discontinuation
- 2004-06-10 UY UY28356A patent/UY28356A1/es not_active Application Discontinuation
-
2005
- 2005-11-17 IL IL172023A patent/IL172023A0/en unknown
- 2005-12-05 ZA ZA200509863A patent/ZA200509863B/en unknown
- 2005-12-05 CO CO05123380A patent/CO5660260A2/es not_active Application Discontinuation
-
2006
- 2006-01-04 IS IS8219A patent/IS8219A/is unknown
- 2006-01-10 NO NO20060147A patent/NO20060147L/no not_active Application Discontinuation
-
2009
- 2009-01-08 US US12/350,322 patent/US20090111865A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060205802A1 (en) | 2006-09-14 |
| TW200504029A (en) | 2005-02-01 |
| WO2004108712A1 (en) | 2004-12-16 |
| ZA200509863B (en) | 2006-12-27 |
| JP2006527249A (ja) | 2006-11-30 |
| NO20060147L (no) | 2006-03-07 |
| AU2004245298A1 (en) | 2004-12-16 |
| CN1805956A (zh) | 2006-07-19 |
| US7501447B2 (en) | 2009-03-10 |
| IS8219A (is) | 2006-01-04 |
| CN100455580C (zh) | 2009-01-28 |
| KR20060018258A (ko) | 2006-02-28 |
| CO5660260A2 (es) | 2006-07-31 |
| UY28356A1 (es) | 2005-01-31 |
| BRPI0411246A (pt) | 2006-07-18 |
| US20090111865A1 (en) | 2009-04-30 |
| SE0301701D0 (sv) | 2003-06-10 |
| CA2528925A1 (en) | 2004-12-16 |
| RU2005138366A (ru) | 2006-07-27 |
| EP1636214A1 (en) | 2006-03-22 |
| IL172023A0 (en) | 2009-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |