AR044482A1 - Profarmacos inhibidores de beta-lactamasa - Google Patents
Profarmacos inhibidores de beta-lactamasaInfo
- Publication number
- AR044482A1 AR044482A1 ARP040101928A ARP040101928A AR044482A1 AR 044482 A1 AR044482 A1 AR 044482A1 AR P040101928 A ARP040101928 A AR P040101928A AR P040101928 A ARP040101928 A AR P040101928A AR 044482 A1 AR044482 A1 AR 044482A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- mammal
- present
- lactam antibiotic
- propharmaces
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Profármacos de sulfona del ácido 6-beta-hidroximetilpenicilánico que tienen las estructuras (1) o (2), en la que R es H o metilo, cada X es metileno, e Y es O, o en la que R es H, cada X es O e Y es metileno, y solvatos de los mismos. Composiciones farmacéuticas que comprenden un profármaco de la presente, o un solvato del mismo, un antibiótico beta-lactama opcional y al menos un vehículo farmacéuticamente aceptable. Un procedimiento para aumentar la eficacia terapéutica de un antibiótico beta-lactama en un mamífero mediante la administración de una cantidad eficaz de un antibiótico beta-lactama y una cantidad que aumenta la eficacia de un profármaco de la presente , o un solvato del mismo. Un procedimiento para tratar una infección bacteriana en un mamífero mediante la administración de una cantidad terapéuticamente eficaz de una composición farmacéutica de la presente a un mamífero necesitado de ello.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47645603P | 2003-06-05 | 2003-06-05 | |
| US49842203P | 2003-08-27 | 2003-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044482A1 true AR044482A1 (es) | 2005-09-14 |
Family
ID=33514083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101928A AR044482A1 (es) | 2003-06-05 | 2004-06-03 | Profarmacos inhibidores de beta-lactamasa |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20050004093A1 (es) |
| EP (1) | EP1636240A1 (es) |
| JP (1) | JP2006526612A (es) |
| AR (1) | AR044482A1 (es) |
| BR (1) | BRPI0410936A (es) |
| CA (1) | CA2528065A1 (es) |
| CL (1) | CL2004001343A1 (es) |
| MX (1) | MXPA05012895A (es) |
| NL (1) | NL1026340C2 (es) |
| PA (1) | PA8604001A1 (es) |
| PE (1) | PE20050629A1 (es) |
| TW (1) | TW200504010A (es) |
| UY (1) | UY28340A1 (es) |
| WO (1) | WO2004108733A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8579701A1 (es) * | 2002-08-23 | 2005-05-24 | Pfizer Prod Inc | Profarmaco inhibidor de beta-lactamasa |
| WO2004087331A1 (de) | 2002-10-14 | 2004-10-14 | H. Börger & Co. GmbH | Verfahren und vorrichtung zum fördern von pulverförmigem material |
| GB201407506D0 (en) | 2014-04-29 | 2014-06-11 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US9737505B2 (en) | 2014-04-29 | 2017-08-22 | Glaxosmithkline Intellectual Property Development Limited | Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE34011B1 (en) * | 1969-03-13 | 1975-01-08 | Leo Pharm Prod Ltd | New penicillin esters |
| IE34019B1 (en) * | 1969-03-18 | 1975-01-08 | Leo Pharm Prod Ltd | New semi-synthetic penicillin esters |
| US3957764A (en) * | 1969-11-11 | 1976-05-18 | Lovens Kemiske Fabrik Produktionsaktieselskab | 6-aminopenicillanic acid derivatives |
| US3862181A (en) * | 1970-10-28 | 1975-01-21 | Squibb & Sons Inc | Process for preparing cephalosporins |
| US4397783A (en) * | 1979-03-05 | 1983-08-09 | Pfizer Inc. | Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
| US4432970A (en) * | 1979-11-23 | 1984-02-21 | Pfizer Inc. | 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
| GB2076812A (en) * | 1980-05-22 | 1981-12-09 | Ciba Geigy Ag | Penam-dioxide compounds, processes for their manufacture, and their use |
| AU559689B2 (en) * | 1981-09-22 | 1987-03-19 | Kureha Kagaku Kogyo K.K. | Penicillin derivative |
| US4406887A (en) * | 1981-10-13 | 1983-09-27 | Bristol-Myers Company | Method for treating resistant bacteria including anaerobes |
| US4377590A (en) * | 1982-05-10 | 1983-03-22 | Pfizer Inc. | Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors |
| US4428935A (en) * | 1982-05-24 | 1984-01-31 | Pfizer Inc. | Penicillanic acid dioxide prodrug |
| US4826833A (en) * | 1984-01-30 | 1989-05-02 | Pfizer Inc. | 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof |
| US4521533A (en) * | 1984-07-12 | 1985-06-04 | Pfizer Inc. | Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics |
| US4762921A (en) * | 1985-04-18 | 1988-08-09 | Pfizer Inc. | 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives |
| US5200403A (en) * | 1987-07-10 | 1993-04-06 | Farmitalia Carlo Erba S.R.L. | Inhibition of βlactamase with 6 β-(substituted methyl)-penicillanic acid derivatives |
| JPH03206038A (ja) * | 1990-01-08 | 1991-09-09 | Yoshitomi Pharmaceut Ind Ltd | 抗菌剤 |
| GB9001405D0 (en) * | 1990-01-22 | 1990-03-21 | Leo Pharm Prod Ltd | New intermediates,their production and use |
| EP0544906B1 (en) * | 1990-08-20 | 1999-11-10 | Suntory Limited | Antibacterial penem esters derivatives |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| US6156745A (en) * | 1997-12-29 | 2000-12-05 | Research Corporation Technologies, Inc. | 2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors |
| US6160112A (en) * | 1999-03-03 | 2000-12-12 | Alex-Gyogyszer Kutatasi, Fejlesztesi es Tanacsado Korlatot Felelossegu Tarsagag | Procedure for the preparation of dioxopenicillanic acid derivatives |
| PA8579701A1 (es) * | 2002-08-23 | 2005-05-24 | Pfizer Prod Inc | Profarmaco inhibidor de beta-lactamasa |
-
2004
- 2004-05-24 JP JP2006508430A patent/JP2006526612A/ja active Pending
- 2004-05-24 BR BRPI0410936-8A patent/BRPI0410936A/pt not_active IP Right Cessation
- 2004-05-24 MX MXPA05012895A patent/MXPA05012895A/es not_active Application Discontinuation
- 2004-05-24 WO PCT/IB2004/001824 patent/WO2004108733A1/en not_active Application Discontinuation
- 2004-05-24 CA CA002528065A patent/CA2528065A1/en not_active Abandoned
- 2004-05-24 EP EP04734576A patent/EP1636240A1/en not_active Withdrawn
- 2004-06-01 CL CL200401343A patent/CL2004001343A1/es unknown
- 2004-06-02 UY UY28340A patent/UY28340A1/es not_active Application Discontinuation
- 2004-06-02 PE PE2004000557A patent/PE20050629A1/es not_active Application Discontinuation
- 2004-06-02 PA PA20048604001A patent/PA8604001A1/es unknown
- 2004-06-03 AR ARP040101928A patent/AR044482A1/es unknown
- 2004-06-04 TW TW093116149A patent/TW200504010A/zh unknown
- 2004-06-04 NL NL1026340A patent/NL1026340C2/nl not_active IP Right Cessation
- 2004-06-07 US US10/862,200 patent/US20050004093A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CL2004001343A1 (es) | 2005-04-22 |
| UY28340A1 (es) | 2005-01-31 |
| NL1026340C2 (nl) | 2005-09-14 |
| PA8604001A1 (es) | 2004-12-16 |
| NL1026340A1 (nl) | 2004-12-07 |
| TW200504010A (en) | 2005-02-01 |
| WO2004108733A1 (en) | 2004-12-16 |
| EP1636240A1 (en) | 2006-03-22 |
| BRPI0410936A (pt) | 2006-06-27 |
| PE20050629A1 (es) | 2005-08-25 |
| MXPA05012895A (es) | 2006-02-22 |
| CA2528065A1 (en) | 2004-12-16 |
| JP2006526612A (ja) | 2006-11-24 |
| US20050004093A1 (en) | 2005-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |