PE20050629A1 - PROFARMACO DE SULFONA DEL ACIDO 6-ß-HIDROXIMETILPENICILANICO COMO INHIBIDOR DE BETA-LACTAMASA - Google Patents

PROFARMACO DE SULFONA DEL ACIDO 6-ß-HIDROXIMETILPENICILANICO COMO INHIBIDOR DE BETA-LACTAMASA

Info

Publication number
PE20050629A1
PE20050629A1 PE2004000557A PE2004000557A PE20050629A1 PE 20050629 A1 PE20050629 A1 PE 20050629A1 PE 2004000557 A PE2004000557 A PE 2004000557A PE 2004000557 A PE2004000557 A PE 2004000557A PE 20050629 A1 PE20050629 A1 PE 20050629A1
Authority
PE
Peru
Prior art keywords
hydroximethyl
beta
acid
thia
dioxo
Prior art date
Application number
PE2004000557A
Other languages
English (en)
Inventor
John Paul O'donnell
Anthony Marfat
Dale Gordon Mcleod
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20050629A1 publication Critical patent/PE20050629A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings

Abstract

SE REFIERE A PROFARMACOS DE SULFONA DEL ACIDO 6-b-HIDROXIMETILPENICILANICO (TAMBIEN DENOMINADO ACIDO (2S,5R,6R) 4,4-DIOXO-6--(HIDROXIMETIL)-3,3-DIMETIL-7-OXO-4-TIA-1-AZABICICLO[3.2.0]HEPTANO-2-CARBOXILICO), SIENDO COMPUESTOS PREFERIDOS: ESTER [[[(TETRAHIDRO-2H-PIRAN-4-IL)OXI]CARBONIL]OXI]METILICO DEL ACIDO (2S,5R,6R) 4,4-DIOXO-6-(HIDROXIMETIL)-3,3-DIMETIL-7-OXO-4-TIA-1-AZABICICLO[3.2.0]HEPTANO-2-CARBOXILICO, ESTER [[(1,3-DIOXAN-5-ILOXI)-CARBONIL]OXI]METILICO DEL ACIDO (2S,5R,6R) 4,4-DIOXO-6-(HIDROXIMETIL)-3,3-DIMETIL-7-OXO-4-TIA-1-AZABICICLO[3.2.0]HEPTANO-2-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN PROFARMACO O UN SOLVATO DEL MISMO Y OPCIONALMENTE UN ANTIBIOTICO BETA-LACTAMICO COMO AMOXICILINA Y UN EXCIPIENTE FARMACEUTICAMENTE ACEPTABLE, MEDIANTE EL CUAL SE LOGRA UN AUMENTO DE LA EFICACIA TERAPEUTICA DEL ANTIBIOTICO BETA-LACTAMICO EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
PE2004000557A 2003-06-05 2004-06-02 PROFARMACO DE SULFONA DEL ACIDO 6-ß-HIDROXIMETILPENICILANICO COMO INHIBIDOR DE BETA-LACTAMASA PE20050629A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47645603P 2003-06-05 2003-06-05
US49842203P 2003-08-27 2003-08-27

Publications (1)

Publication Number Publication Date
PE20050629A1 true PE20050629A1 (es) 2005-08-25

Family

ID=33514083

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000557A PE20050629A1 (es) 2003-06-05 2004-06-02 PROFARMACO DE SULFONA DEL ACIDO 6-ß-HIDROXIMETILPENICILANICO COMO INHIBIDOR DE BETA-LACTAMASA

Country Status (14)

Country Link
US (1) US20050004093A1 (es)
EP (1) EP1636240A1 (es)
JP (1) JP2006526612A (es)
AR (1) AR044482A1 (es)
BR (1) BRPI0410936A (es)
CA (1) CA2528065A1 (es)
CL (1) CL2004001343A1 (es)
MX (1) MXPA05012895A (es)
NL (1) NL1026340C2 (es)
PA (1) PA8604001A1 (es)
PE (1) PE20050629A1 (es)
TW (1) TW200504010A (es)
UY (1) UY28340A1 (es)
WO (1) WO2004108733A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
WO2004087331A1 (de) 2002-10-14 2004-10-14 H. Börger & Co. GmbH Verfahren und vorrichtung zum fördern von pulverförmigem material
US9737505B2 (en) 2014-04-29 2017-08-22 Glaxosmithkline Intellectual Property Development Limited Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
GB201407506D0 (en) 2014-04-29 2014-06-11 Glaxosmithkline Ip Dev Ltd Novel compound

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34011B1 (en) * 1969-03-13 1975-01-08 Leo Pharm Prod Ltd New penicillin esters
IE34019B1 (en) * 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
US3957764A (en) * 1969-11-11 1976-05-18 Lovens Kemiske Fabrik Produktionsaktieselskab 6-aminopenicillanic acid derivatives
US3862181A (en) * 1970-10-28 1975-01-21 Squibb & Sons Inc Process for preparing cephalosporins
US4397783A (en) * 1979-03-05 1983-08-09 Pfizer Inc. Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
DE3274453D1 (en) * 1981-09-22 1987-01-15 Kureha Chemical Ind Co Ltd Penicillin derivatives
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US4521533A (en) * 1984-07-12 1985-06-04 Pfizer Inc. Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
US4762921A (en) * 1985-04-18 1988-08-09 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US5200403A (en) * 1987-07-10 1993-04-06 Farmitalia Carlo Erba S.R.L. Inhibition of βlactamase with 6 β-(substituted methyl)-penicillanic acid derivatives
JPH03206038A (ja) * 1990-01-08 1991-09-09 Yoshitomi Pharmaceut Ind Ltd 抗菌剤
GB9001405D0 (en) * 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
US5703068A (en) * 1990-08-20 1997-12-30 Suntory Limited Penem compounds
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
ES2178301T3 (es) * 1997-12-29 2002-12-16 Res Corp Technologies Inc Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama.
ES2237064T3 (es) * 1999-03-03 2005-07-16 Astur Pharma S.A. Procedimiento para preparar derivados de acido dioxopenicilanico.
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa

Also Published As

Publication number Publication date
EP1636240A1 (en) 2006-03-22
WO2004108733A1 (en) 2004-12-16
BRPI0410936A (pt) 2006-06-27
MXPA05012895A (es) 2006-02-22
NL1026340C2 (nl) 2005-09-14
PA8604001A1 (es) 2004-12-16
CA2528065A1 (en) 2004-12-16
TW200504010A (en) 2005-02-01
AR044482A1 (es) 2005-09-14
UY28340A1 (es) 2005-01-31
NL1026340A1 (nl) 2004-12-07
US20050004093A1 (en) 2005-01-06
CL2004001343A1 (es) 2005-04-22
JP2006526612A (ja) 2006-11-24

Similar Documents

Publication Publication Date Title
ES2546847T3 (es) Formulaciones de un inhibidor de la Src/Abl
AR050838A1 (es) Formulacion farmaceutica. para el tratamiento de una infeccion optica
BRPI0507897B8 (pt) formulação de droga sólida
HK1076605A1 (en) Formulations
WO2005069933A3 (en) Methods of treating an inflammatory-related disease
WO2006069155A3 (en) Inhibitors of protein arginine methyl transferases
AUPR213700A0 (en) Antiviral agents
UY27598A1 (es) Composiciones farmacéuticas de derivados de taxano oralmente activos que tienen biodisponibilidad mejorada
EA201000643A1 (ru) Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе
ECSP066693A (es) Derivados de bencimidazol
AR052853A1 (es) Composiciones orales que contienen compuestos antibacterianos de bifenol
DE60123277D1 (de) Makrolidantibiotika
ES2129078T3 (es) Preparacion farmaceutica que comprende un compuesto capaz de degradar los antibioticos beta-lactamicos y su utilizacion.
WO2004096823A3 (en) Novel ketolide derivatives
WO2004112718A3 (en) Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
ATE466008T1 (de) P-glycoprotein-inhibitor, verfahren zu dessen herstellung und pharmazeutische zusammensetzung, die diesen enthält
PL361061A1 (en) Crystalline forms of fluvastatin sodium
WO2004096822A3 (en) Pyridyl substituted ketolide antibiotics
WO2006078724A3 (en) Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases
UY29402A1 (es) Composiciones antifúngicas
PE20050629A1 (es) PROFARMACO DE SULFONA DEL ACIDO 6-ß-HIDROXIMETILPENICILANICO COMO INHIBIDOR DE BETA-LACTAMASA
AR039703A1 (es) Composiciones nasales
WO2007062334A3 (en) New pleuromutilin derivative and its use
JP2005539037A5 (es)
WO2005055933A3 (en) Treatment of psoriasis with rosiglitazone

Legal Events

Date Code Title Description
FA Abandonment or withdrawal