WO2007062334A3 - New pleuromutilin derivative and its use - Google Patents

New pleuromutilin derivative and its use Download PDF

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Publication number
WO2007062334A3
WO2007062334A3 PCT/US2006/061067 US2006061067W WO2007062334A3 WO 2007062334 A3 WO2007062334 A3 WO 2007062334A3 US 2006061067 W US2006061067 W US 2006061067W WO 2007062334 A3 WO2007062334 A3 WO 2007062334A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
skin
pleuromutilin derivative
respiratory tract
further directed
Prior art date
Application number
PCT/US2006/061067
Other languages
French (fr)
Other versions
WO2007062334A2 (en
WO2007062334A8 (en
Inventor
Ju Yang
Original Assignee
Glaxo Group Ltd
Ju Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Ju Yang filed Critical Glaxo Group Ltd
Publication of WO2007062334A2 publication Critical patent/WO2007062334A2/en
Publication of WO2007062334A3 publication Critical patent/WO2007062334A3/en
Publication of WO2007062334A8 publication Critical patent/WO2007062334A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is directed to the ethanedisulfonate salt of trans-4-aminocyclohexyl (lS, 2R, 3S, 4S, 6R, 7R, 8R, 14R )-4-ethenyl-3-hydroxy-2,4J7,14-tetramethyl-9- oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compound IA is use for the treatment of a variety of diseases and conditions, such as respiratory tract and skin an skin structure infections. Accordingly, the invention is further directed to pharmaceutical compositions comprising Compound IA. The invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA.
PCT/US2006/061067 2005-11-18 2006-11-18 New pleuromutilin derivative and its use WO2007062334A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73820305P 2005-11-18 2005-11-18
US60/738,203 2005-11-18

Publications (3)

Publication Number Publication Date
WO2007062334A2 WO2007062334A2 (en) 2007-05-31
WO2007062334A3 true WO2007062334A3 (en) 2007-11-08
WO2007062334A8 WO2007062334A8 (en) 2007-12-21

Family

ID=38068018

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/061067 WO2007062334A2 (en) 2005-11-18 2006-11-18 New pleuromutilin derivative and its use
PCT/US2006/061068 WO2007062335A2 (en) 2005-11-18 2006-11-18 New pleuromutilin derivative and its use

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2006/061068 WO2007062335A2 (en) 2005-11-18 2006-11-18 New pleuromutilin derivative and its use

Country Status (3)

Country Link
PE (1) PE20070825A1 (en)
TW (1) TW200738599A (en)
WO (2) WO2007062334A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101671367B (en) * 2008-09-12 2012-09-05 中国科学院上海药物研究所 Pleuromutilin phosphate compounds, medicinal composition thereof, preparation method thereof and application thereof
JP2010100582A (en) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd Mutilin derivative containing heteroaromatic ring carboxylic acid structure at 14-position substituent
CN103641702B (en) * 2013-11-18 2015-11-18 宁夏泰瑞制药股份有限公司 A kind of method for hydrolysis of pleuromutilin
TWI762573B (en) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 Purification of pleuromutilin
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
US6750064B2 (en) * 2000-12-28 2004-06-15 S.S.C.I. Inc. Methods of screening for possible solid forms
US20050096357A1 (en) * 2000-10-10 2005-05-05 Smithkline Beecham P.L.C. Novel pleuromutilin derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060542A (en) * 1969-07-25 1977-11-29 Biochemie Gesellschaft M.B.H. 14-Desoxy-14 thiocyanato-acetoxy-mutilin
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
US20050096357A1 (en) * 2000-10-10 2005-05-05 Smithkline Beecham P.L.C. Novel pleuromutilin derivatives
US6750064B2 (en) * 2000-12-28 2004-06-15 S.S.C.I. Inc. Methods of screening for possible solid forms

Also Published As

Publication number Publication date
WO2007062335A3 (en) 2007-11-29
PE20070825A1 (en) 2007-08-05
WO2007062334A2 (en) 2007-05-31
TW200738599A (en) 2007-10-16
WO2007062334A8 (en) 2007-12-21
WO2007062335A2 (en) 2007-05-31
WO2007062335A8 (en) 2008-07-10

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