TW200738599A - New pleuromutilin derivative and its use - Google Patents

New pleuromutilin derivative and its use

Info

Publication number
TW200738599A
TW200738599A TW095142514A TW95142514A TW200738599A TW 200738599 A TW200738599 A TW 200738599A TW 095142514 A TW095142514 A TW 095142514A TW 95142514 A TW95142514 A TW 95142514A TW 200738599 A TW200738599 A TW 200738599A
Authority
TW
Taiwan
Prior art keywords
compound
skin
respiratory tract
pleuromutilin derivative
further directed
Prior art date
Application number
TW095142514A
Other languages
Chinese (zh)
Inventor
Ann Marie Diederich
Joseph Sisko
Frederick G Vogt
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of TW200738599A publication Critical patent/TW200738599A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is directed to the succinate salt of trans-4-aminocyclohexyl (1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7, 14-tetramethyl-9-oxotricyclo [5.4.3.01,8] tetradec-6-yl imidodicarbonate (Compound IA). compound IA is useful for the treatment of a variety of diseases and conditions, such as respiratory tract and skin and skin structure infections. Accordingly, the invention is further directed to pharmaceutical compositions comprising Compound IA. The invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA.
TW095142514A 2005-11-18 2006-11-17 New pleuromutilin derivative and its use TW200738599A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73820305P 2005-11-18 2005-11-18

Publications (1)

Publication Number Publication Date
TW200738599A true TW200738599A (en) 2007-10-16

Family

ID=38068018

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095142514A TW200738599A (en) 2005-11-18 2006-11-17 New pleuromutilin derivative and its use

Country Status (3)

Country Link
PE (1) PE20070825A1 (en)
TW (1) TW200738599A (en)
WO (2) WO2007062335A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101671367B (en) * 2008-09-12 2012-09-05 中国科学院上海药物研究所 Pleuromutilin phosphate compounds, medicinal composition thereof, preparation method thereof and application thereof
JP2010100582A (en) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd Mutilin derivative containing heteroaromatic ring carboxylic acid structure at 14-position substituent
CN103641702B (en) * 2013-11-18 2015-11-18 宁夏泰瑞制药股份有限公司 A kind of method for hydrolysis of pleuromutilin
TWI762573B (en) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 Purification of pleuromutilin
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060542A (en) * 1969-07-25 1977-11-29 Biochemie Gesellschaft M.B.H. 14-Desoxy-14 thiocyanato-acetoxy-mutilin
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
GB0024811D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US6750064B2 (en) * 2000-12-28 2004-06-15 S.S.C.I. Inc. Methods of screening for possible solid forms

Also Published As

Publication number Publication date
WO2007062334A3 (en) 2007-11-08
WO2007062335A2 (en) 2007-05-31
WO2007062334A2 (en) 2007-05-31
WO2007062334A8 (en) 2007-12-21
PE20070825A1 (en) 2007-08-05
WO2007062335A3 (en) 2007-11-29
WO2007062335A8 (en) 2008-07-10

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