AR043752A1 - Esteres del acido 2-clorometil-6-metilbenzoico y proceso de sintesis - Google Patents
Esteres del acido 2-clorometil-6-metilbenzoico y proceso de sintesisInfo
- Publication number
- AR043752A1 AR043752A1 ARP040100955A ARP040100955A AR043752A1 AR 043752 A1 AR043752 A1 AR 043752A1 AR P040100955 A ARP040100955 A AR P040100955A AR P040100955 A ARP040100955 A AR P040100955A AR 043752 A1 AR043752 A1 AR 043752A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- chlorometil
- esteres
- synthesis process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicación 6: Un procedimiento para preparar los compuestos de fórmula (1), en la que: R es H, alquilo C1-12, cicloalquilo C3-8, arilo C6-12, alquil(C1-4)-arilo(C6-12) o heteroarilo C5-10, y en el alquilo y cicloalquilo uno o más grupos CH2 se pueden sustituir por -O-, y el alquilo, cicloalquilo y arilo pueden estar sustituidos con halógeno, Y es -(CH2)3-, 1,3-fenileno, 1,3-ciclohexanodiilo; R' es H, F, Br, CF3, alquilo (C1-6), -O-alquilo (c1-6), fenilo; R'' es H, alquilo (C1-6), alquil(C1-3)-fenilo, cicloalquilo (C5-6), fenilo, CF3; que comprende hacer reaccionar compuestos de fórmula (2), donde Y, R' y R'' es cada uno como se ha definido antes con compuestos de fórmula (3), donde R es como se ha definido antes, en tolueno, NMP u otros disolventes apróticos, en presencia de una base adecuada, de -78 a +50° C, y posteriormente tratar por extracción y opcionalmente cristalizar el producto final.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10313228A DE10313228A1 (de) | 2003-03-25 | 2003-03-25 | Synthese von 2-Chlormethyl-6-methylbenzoesäureestern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043752A1 true AR043752A1 (es) | 2005-08-10 |
Family
ID=33015963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100955A AR043752A1 (es) | 2003-03-25 | 2004-03-23 | Esteres del acido 2-clorometil-6-metilbenzoico y proceso de sintesis |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1611083B1 (es) |
| JP (1) | JP4510805B2 (es) |
| KR (1) | KR20050116388A (es) |
| CN (1) | CN100378065C (es) |
| AR (1) | AR043752A1 (es) |
| AT (1) | ATE374742T1 (es) |
| AU (1) | AU2004224177B2 (es) |
| BR (1) | BRPI0408653A (es) |
| CA (1) | CA2519715A1 (es) |
| CO (1) | CO5690546A2 (es) |
| CY (1) | CY1107029T1 (es) |
| DE (2) | DE10313228A1 (es) |
| DK (1) | DK1611083T3 (es) |
| ES (1) | ES2293237T3 (es) |
| HK (1) | HK1087098A1 (es) |
| IL (1) | IL171031A (es) |
| MX (1) | MXPA05010001A (es) |
| NO (1) | NO20054875L (es) |
| NZ (1) | NZ542603A (es) |
| PL (1) | PL1611083T3 (es) |
| PT (1) | PT1611083E (es) |
| RU (1) | RU2345982C2 (es) |
| TW (1) | TW200502213A (es) |
| WO (1) | WO2004085377A1 (es) |
| ZA (1) | ZA200506499B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005029382B3 (de) | 2005-06-24 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Alkoxymethylyl-substituierte Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| CN114805120A (zh) * | 2022-05-23 | 2022-07-29 | 江苏瑞达环保科技有限公司 | 一种间氰甲基苯甲酸甲酯的合成工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689425A (en) * | 1986-11-06 | 1987-08-25 | Stauffer Chemical Company | Photochlorination of aromatic compounds in the side chain |
| SK15522001A3 (sk) * | 1999-04-28 | 2002-06-04 | Aventis Pharma Deutschland Gmbh | Deriváty kyselín s tromi arylovými zvyškami ako ligandy receptorov PPAR a farmaceutické kompozície, ktoré ich obsahujú |
| ES2287016T3 (es) * | 1999-04-28 | 2007-12-16 | Sanofi-Aventis Deutschland Gmbh | Derivados de diaril-acido como ligandos del receptor ppar. |
| UA76773C2 (uk) * | 2001-08-31 | 2006-09-15 | Санофі-Авентіс Дойчланд Гмбх | Діарилциклоалкільні похідні, спосіб їх одержання і їх застосування як ppar-активаторів |
-
2003
- 2003-03-25 DE DE10313228A patent/DE10313228A1/de not_active Withdrawn
-
2004
- 2004-03-12 RU RU2005132827/04A patent/RU2345982C2/ru not_active IP Right Cessation
- 2004-03-12 PL PL04719953T patent/PL1611083T3/pl unknown
- 2004-03-12 AU AU2004224177A patent/AU2004224177B2/en not_active Ceased
- 2004-03-12 CN CNB2004800062464A patent/CN100378065C/zh not_active Expired - Fee Related
- 2004-03-12 WO PCT/EP2004/002579 patent/WO2004085377A1/de active IP Right Grant
- 2004-03-12 KR KR1020057017893A patent/KR20050116388A/ko not_active Application Discontinuation
- 2004-03-12 AT AT04719953T patent/ATE374742T1/de not_active IP Right Cessation
- 2004-03-12 DE DE502004005137T patent/DE502004005137D1/de not_active Expired - Lifetime
- 2004-03-12 JP JP2006504662A patent/JP4510805B2/ja not_active Expired - Fee Related
- 2004-03-12 BR BRPI0408653-8A patent/BRPI0408653A/pt not_active IP Right Cessation
- 2004-03-12 PT PT04719953T patent/PT1611083E/pt unknown
- 2004-03-12 MX MXPA05010001A patent/MXPA05010001A/es active IP Right Grant
- 2004-03-12 EP EP04719953A patent/EP1611083B1/de not_active Expired - Lifetime
- 2004-03-12 ES ES04719953T patent/ES2293237T3/es not_active Expired - Lifetime
- 2004-03-12 NZ NZ542603A patent/NZ542603A/en unknown
- 2004-03-12 DK DK04719953T patent/DK1611083T3/da active
- 2004-03-12 CA CA002519715A patent/CA2519715A1/en not_active Abandoned
- 2004-03-23 AR ARP040100955A patent/AR043752A1/es not_active Application Discontinuation
- 2004-03-23 TW TW093107693A patent/TW200502213A/zh unknown
-
2005
- 2005-08-15 ZA ZA200506499A patent/ZA200506499B/en unknown
- 2005-09-21 IL IL171031A patent/IL171031A/en not_active IP Right Cessation
- 2005-09-23 CO CO05096625A patent/CO5690546A2/es active IP Right Grant
- 2005-10-21 NO NO20054875A patent/NO20054875L/no not_active Application Discontinuation
-
2006
- 2006-06-28 HK HK06107312A patent/HK1087098A1/xx not_active IP Right Cessation
-
2007
- 2007-12-04 CY CY20071101544T patent/CY1107029T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2345982C2 (ru) | 2009-02-10 |
| DK1611083T3 (da) | 2008-01-21 |
| NO20054875L (no) | 2005-12-27 |
| HK1087098A1 (en) | 2006-10-06 |
| IL171031A (en) | 2010-11-30 |
| ZA200506499B (en) | 2006-07-26 |
| ES2293237T3 (es) | 2008-03-16 |
| ATE374742T1 (de) | 2007-10-15 |
| PT1611083E (pt) | 2007-11-26 |
| AU2004224177A1 (en) | 2004-10-07 |
| CA2519715A1 (en) | 2004-10-07 |
| JP2006521307A (ja) | 2006-09-21 |
| PL1611083T3 (pl) | 2008-01-31 |
| EP1611083A1 (de) | 2006-01-04 |
| WO2004085377A1 (de) | 2004-10-07 |
| CO5690546A2 (es) | 2006-10-31 |
| CY1107029T1 (el) | 2012-09-26 |
| NZ542603A (en) | 2007-12-21 |
| MXPA05010001A (es) | 2005-11-17 |
| AU2004224177B2 (en) | 2010-01-21 |
| BRPI0408653A (pt) | 2006-03-07 |
| TW200502213A (en) | 2005-01-16 |
| JP4510805B2 (ja) | 2010-07-28 |
| DE502004005137D1 (en) | 2007-11-15 |
| DE10313228A1 (de) | 2004-10-21 |
| NO20054875D0 (no) | 2005-10-21 |
| KR20050116388A (ko) | 2005-12-12 |
| EP1611083B1 (de) | 2007-10-03 |
| CN1759092A (zh) | 2006-04-12 |
| CN100378065C (zh) | 2008-04-02 |
| RU2005132827A (ru) | 2006-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE502004012095D1 (de) | Verfahren zum herstellen von 2-dihalogenacyl-3-amino-acryls ureestern und 3-dihalogenmethyl-pyrazol-4-carbons ureestern | |
| DE60311599D1 (de) | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten | |
| RU2005127626A (ru) | Способ получения производных топирамата-антиконвульсантов | |
| EA201190205A1 (ru) | ПОЛЕЗНЫЕ ФАРМАЦЕВТИЧЕСКИЕ СОЛИ 7-[(3R,4R)-3-ГИДРОКСИ-4-ГИДРОКСИМЕТИЛПИРРОЛИДИН-1-ИЛМЕТИЛ]-3,5-ДИГИДРОПИРРОЛО[3,2-d]ПИРИМИДИН-4-ОНА | |
| AR061924A1 (es) | Proceso para elaborar 2- amino -5 - halobenzamidas 3- sustituidas | |
| ATE552244T1 (de) | 1-h-benzoägüindol- verbindungen und sie enthaltende organische lichtemittierende vorrichtung | |
| EP2543646A4 (en) | LUMINOUS NANOVERRE CERAMIC AS A SOURCE OF WHITE LED AND METHOD FOR THE PREPARATION OF LUMINOUS NANOVERRE CERAMIC | |
| AR057022A1 (es) | Proceso para resolver un r o s acido mandelico a partir de su mezcla racemica | |
| WO2010147965A3 (en) | Process for production of heterodimers of glutamic acid | |
| HRP20080510T3 (en) | Process for the preparation of optically active derivatives of 2-(2-pyridylmethylsulfinyl)-benzimidazole via inclusion complex with 1,1'-binaphthalene-2, 2'diol | |
| RU2014153544A (ru) | Стеклянный контейнер и способ его изготовления | |
| WO2009139579A3 (ko) | 비대칭 안트라센 유도체의 제조 및 이를 이용한 유기전계 발광 소자 | |
| CN110627690A (zh) | 一类新型对香豆酸磺酸酯衍生物及其制备方法和应用 | |
| Huang et al. | A facile synthesis of β-amino carbonyl compounds through an aza-Michael addition reaction under solvent-free conditions | |
| AR043752A1 (es) | Esteres del acido 2-clorometil-6-metilbenzoico y proceso de sintesis | |
| BR0308345A (pt) | Processo para derivados de ácido trans-4-amino-1-cicloexanocarboxìlico | |
| ATE370736T1 (de) | Verfahren zur herstellung eines piperazinderivates | |
| CN103539737A (zh) | 一种氮杂菲并芴类衍生物、制备方法及电致荧光发光器件 | |
| JP2013543861A5 (es) | ||
| CN102863451B (zh) | 含三苯胺分子的色烯并二氮杂萘荧光化合物的制备方法及其用途 | |
| Shoji et al. | Synthesis of 2, 6-diaminoazulenes by the SNAr reaction with cyclic amines | |
| EA201390016A1 (ru) | Способ получения производных пирано[2,3-c]пиридина | |
| JP2012240959A (ja) | 光学活性β−アミノチオールまたは光学活性β−アミノスルホン酸誘導体の合成法 | |
| CN109134379B (zh) | 一种三苯胺-咪唑衍生物及其制备方法与应用 | |
| CN110256368B (zh) | 一种脒类化合物与氮杂环丙烷化合物环加成的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |