EA201390016A1 - Способ получения производных пирано[2,3-c]пиридина - Google Patents

Способ получения производных пирано[2,3-c]пиридина

Info

Publication number
EA201390016A1
EA201390016A1 EA201390016A EA201390016A EA201390016A1 EA 201390016 A1 EA201390016 A1 EA 201390016A1 EA 201390016 A EA201390016 A EA 201390016A EA 201390016 A EA201390016 A EA 201390016A EA 201390016 A1 EA201390016 A1 EA 201390016A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pirano
pyridine
derivatives
producing
formula
Prior art date
Application number
EA201390016A
Other languages
English (en)
Inventor
Джозеф Сиско
Дуглас Манс
Хао Йинь
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA201390016A1 publication Critical patent/EA201390016A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Изобретение относится к способу, включающему стадию дегидратирования соединения формулы (I)подходящим дегидратирующим реагентом с образованием соединения формулы (II)где R-Rтакие, как определено в описании. Соединения формулы (II) являются перспективными в качестве промежуточных соединений для синтеза соединений, полезных для лечения бактериальных инфекций.
EA201390016A 2010-07-20 2011-07-19 Способ получения производных пирано[2,3-c]пиридина EA201390016A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36588010P 2010-07-20 2010-07-20
PCT/US2011/044489 WO2012012391A2 (en) 2010-07-20 2011-07-19 Process for preparing pyrano - [2,3-c]pyridine derivatives

Publications (1)

Publication Number Publication Date
EA201390016A1 true EA201390016A1 (ru) 2013-09-30

Family

ID=45497409

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390016A EA201390016A1 (ru) 2010-07-20 2011-07-19 Способ получения производных пирано[2,3-c]пиридина

Country Status (10)

Country Link
US (1) US8759523B2 (ru)
EP (1) EP2595994B1 (ru)
JP (1) JP5762538B2 (ru)
KR (1) KR20130129902A (ru)
CN (1) CN103492393A (ru)
BR (1) BR112013001257A2 (ru)
EA (1) EA201390016A1 (ru)
ES (1) ES2574179T3 (ru)
SG (1) SG187146A1 (ru)
WO (1) WO2012012391A2 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41169A (fr) 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
CN105954913B (zh) 2016-06-24 2021-02-26 京东方科技集团股份有限公司 一种液晶显示器及显示装置
CN112830933A (zh) * 2021-02-04 2021-05-25 康化（上海）新药研发有限公司 一种3,4-二氢-2H-吡喃并[2,3-b]吡啶合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613786D0 (en) 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
JP2005510523A (ja) * 2001-11-09 2005-04-21 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー アザ二環式フェニル縮合複素環式化合物、及びα７ＮＡＣＨＲリガンドとしての当該化合物の使用
TW200427688A (en) * 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents

Also Published As

Publication number Publication date
KR20130129902A (ko) 2013-11-29
JP5762538B2 (ja) 2015-08-12
EP2595994A4 (en) 2014-12-10
CN103492393A (zh) 2014-01-01
ES2574179T3 (es) 2016-06-15
WO2012012391A3 (en) 2013-08-08
US20130116436A1 (en) 2013-05-09
BR112013001257A2 (pt) 2016-05-17
JP2013541498A (ja) 2013-11-14
EP2595994B1 (en) 2016-04-20
WO2012012391A2 (en) 2012-01-26
SG187146A1 (en) 2013-02-28
EP2595994A2 (en) 2013-05-29
US8759523B2 (en) 2014-06-24

Similar Documents

Publication Publication Date Title
EA201391180A1 (ru) Способ получения оптически активных производных дигидробензофурана
MY197904A (en) Method for producing substituted 5-fluoro-1h-pyrazolopyridines
EA201201179A1 (ru) Способ получения изоксазолиновых производных
EA201100666A1 (ru) Тиоамидные соединения, способ их получения и способ их применения
JO2939B1 (en) Tetrahydro-pyrido-pyrimidine derivatives
MX2009003257A (es) Procedimiento para la sintesis de derivados de fenoxi diaminopirimidina.
MX2013011257A (es) Proceso para la preparacion de dronedarona por n-butilacion.
NZ586187A (en) Processes for the synthesis of sinomenine derivatives and their intermediate
MX2009007436A (es) Derivados espirociclicos de acido tetronico.
IN2014MN01521A (ru)
ATE539054T1 (de) Verfahren zur herstellung von dihydropyrrolderivaten als zwischenprodukte
EA201391554A1 (ru) Способы получения макроциклических депсипептидов и новых промежуточных соединений
CY1111690T1 (el) Μεθοδος για την παρασκευη δροσπιρενονης
EA200801893A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаления
IN2014DN00144A (ru)
EA201490998A1 (ru) Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты
MX2013008164A (es) Proceso para hacer inhibidores de girasa y topoisomerasa iv.
EA201792068A3 (ru) Способ получения органических соединений
EA201270237A1 (ru) Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения, содержащие магний
EA201200820A1 (ru) Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов
EA201390016A1 (ru) Способ получения производных пирано[2,3-c]пиридина
WO2009121710A3 (en) Process for preparing nebivolol
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
EA201291235A1 (ru) Новые способы
EA201300792A1 (ru) Химические соединения