AR043181A1 - Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxiptamina-6 - Google Patents

Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxiptamina-6

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Publication number
AR043181A1
AR043181A1 ARP040100459A ARP040100459A AR043181A1 AR 043181 A1 AR043181 A1 AR 043181A1 AR P040100459 A ARP040100459 A AR P040100459A AR P040100459 A ARP040100459 A AR P040100459A AR 043181 A1 AR043181 A1 AR 043181A1
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Argentina
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optionally substituted
alkyl
cycloalkyl
aryl
group
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ARP040100459A
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Wyeth Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se refiere a heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxitriptamina-6, el uso de los mismos en el tratamiento terapéutico de trastornos relacionados o afectados por el receptor 5-HT6. Reivindicación 1:Un compuesto de fórmula (1) en la cual A es C, CR8 o N; R1 es H, halógeno, CN, COR9, OCO2R10, CO2R11, CONR12R13, SOxR14, NR15R16, OR17 o un grupo alquilo C1-6, cicloalquilo C3-7, arilo o heteroarilo, cada uno opcionalmente sustituido; R2 es un grupo alquilo C1-6, cicloalquilo C3-7, arilo o heteroarilo, o un sistema de anillo bicíclico o tricíclico de 8 a 13 miembros opcionalmente sustituido que tiene un átomo de N en la cabeza del puente y que contiene opcionalmente 1, 2, o 3 heteroátomos adicionales seleccionados entre N, O o S; R3 es H o un grupo alquilo C1-6, cicloalquilo C3-7, arilo o heteroarilo, cada uno opcionalmente sustituido; R4 es H o un grupo alquilo C1-6 o cicloalquilo C3-7, cada uno opcionalmente sustituido; R5, R6 y R7, son cada uno independientemente H o un grupo alquilo C1-6 o cicloalquilo C3-7, cada uno opcionalmente sustituido; m y p son cada una independientemente un número entero de 1, 2 o 3; n es un número entero de 1 o 2; R8 es H, OH o un grupo alcoxi C1-6 opcionalmente sustituido; R9, R10, R11 y R17, son cada uno independientemente H o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; R12, R13, R15 y R16, son cada uno independientemente H o un grupo alquilo C1-4, opcionalmente sustituido R12, y R13 o R15 y R16, pueden ser tomados conjuntamente con el átomo al cual están unidos, para formar un anillo de 5 a 7 miembros que contiene opcionalmente otro heteroátomo seleccionado entre O, NR18 o SOx; R14 es un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; R18 es H o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; x es 0 o un número entero de 1 o 2; y la línea de puntos sobre la línea entera representa un enlace simple o un enlace doble, o un estereoisómero del mismo o una sal del mismo farmacéuticamente aceptable.
ARP040100459A 2003-02-14 2004-02-13 Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxiptamina-6 AR043181A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44761303P 2003-02-14 2003-02-14

Publications (1)

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AR043181A1 true AR043181A1 (es) 2005-07-20

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ID=32908471

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Country Status (21)

Country Link
US (3) US7238696B2 (es)
EP (1) EP1592683A2 (es)
JP (1) JP2006518385A (es)
KR (1) KR20050101551A (es)
CN (1) CN100422171C (es)
AR (1) AR043181A1 (es)
AU (1) AU2004213374A1 (es)
BR (1) BRPI0407253A (es)
CA (1) CA2515570A1 (es)
CO (1) CO5650164A2 (es)
CR (1) CR7930A (es)
EC (1) ECSP055964A (es)
MX (1) MXPA05008438A (es)
NO (1) NO20053792L (es)
NZ (1) NZ541699A (es)
PL (1) PL378120A1 (es)
RU (1) RU2347780C2 (es)
TW (1) TW200505904A (es)
UA (1) UA80184C2 (es)
WO (1) WO2004074243A2 (es)
ZA (1) ZA200506416B (es)

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ZA200506416B (en) 2007-02-28
US20090253711A1 (en) 2009-10-08
CA2515570A1 (en) 2004-09-02
RU2005128556A (ru) 2006-01-27
JP2006518385A (ja) 2006-08-10
US20040167122A1 (en) 2004-08-26
WO2004074243A2 (en) 2004-09-02
TW200505904A (en) 2005-02-16
CR7930A (es) 2006-02-07
CO5650164A2 (es) 2006-06-30
ECSP055964A (es) 2006-01-16
BRPI0407253A (pt) 2006-01-31
MXPA05008438A (es) 2005-10-19
RU2347780C2 (ru) 2009-02-27
EP1592683A2 (en) 2005-11-09
UA80184C2 (en) 2007-08-27
KR20050101551A (ko) 2005-10-24
PL378120A1 (pl) 2006-03-06
US7238696B2 (en) 2007-07-03
US7560470B2 (en) 2009-07-14
CN100422171C (zh) 2008-10-01
WO2004074243A3 (en) 2004-12-02
NO20053792L (no) 2005-08-10
CN1771244A (zh) 2006-05-10
NZ541699A (en) 2009-01-31
US20070232618A1 (en) 2007-10-04
AU2004213374A1 (en) 2004-09-02

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