AR042740A1 - Diazepanes farmaceuticamente activos - Google Patents

Diazepanes farmaceuticamente activos

Info

Publication number
AR042740A1
AR042740A1 ARP040100162A ARP040100162A AR042740A1 AR 042740 A1 AR042740 A1 AR 042740A1 AR P040100162 A ARP040100162 A AR P040100162A AR P040100162 A ARP040100162 A AR P040100162A AR 042740 A1 AR042740 A1 AR 042740A1
Authority
AR
Argentina
Prior art keywords
lfa
pharmaceutically active
aryl
alkyl
substituted
Prior art date
Application number
ARP040100162A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0301561A external-priority patent/GB0301561D0/en
Priority claimed from GB0323976A external-priority patent/GB0323976D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR042740A1 publication Critical patent/AR042740A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen diazepanes farmacéuticamente activos, útiles para el tratamiento de trastornos o enfermedades mediadas por interacciones de LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/CAM-3 o LFA-1/JAM-1. Reivindicación 1: Un compuesto de fórmula (1), en donde: R1 es alquilo C1-4; R2 es alquilo C1-4 no sustituido o alquilo C1-4 sustituido por un arilo C6-18 no sustituido o sustituido, o arilo C6-18 fijado con heterociclilo teniendo 5 ó 6 miembros en el anillo y de 1 a 4 átomos heterogéneos seleccionados de N, O y S; R3 es arilo C6-18, una o más veces sustituidos con halógeno, haloalquilo C1-6, haloalcoxi C1-6, ciano, fenilo, heterociclilo teniendo de 5 ó 6 miembros en el anillo y de 1 a 4 átomos de heterogéneos seleccionados de N, O y S.
ARP040100162A 2003-01-23 2004-01-21 Diazepanes farmaceuticamente activos AR042740A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0301561A GB0301561D0 (en) 2003-01-23 2003-01-23 Organic compounds
GB0323976A GB0323976D0 (en) 2003-10-13 2003-10-13 Organic compounds

Publications (1)

Publication Number Publication Date
AR042740A1 true AR042740A1 (es) 2005-06-29

Family

ID=32773971

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100162A AR042740A1 (es) 2003-01-23 2004-01-21 Diazepanes farmaceuticamente activos

Country Status (19)

Country Link
US (1) US7419976B2 (es)
EP (1) EP1590342A1 (es)
JP (1) JP4644655B2 (es)
KR (1) KR20050095618A (es)
AR (1) AR042740A1 (es)
AU (1) AU2004205504B2 (es)
BR (1) BRPI0406884A (es)
CA (1) CA2509764A1 (es)
CO (1) CO5580804A2 (es)
EC (1) ECSP055917A (es)
MX (1) MXPA05007846A (es)
MY (1) MY141850A (es)
NO (1) NO20053911L (es)
NZ (1) NZ540867A (es)
PE (1) PE20040941A1 (es)
PL (1) PL376540A1 (es)
RU (1) RU2347783C2 (es)
TW (1) TWI311557B (es)
WO (1) WO2004065382A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101278522B1 (ko) 2004-12-02 2013-06-25 다이이찌 산쿄 가부시키가이샤 7원환 화합물 및 그 제조법 및 의약 용도
GB0507918D0 (en) * 2005-04-19 2005-05-25 Novartis Ag Organic compounds
WO2010126968A1 (en) * 2009-04-28 2010-11-04 Optmed, Inc. Compositions and methods for treating or preventing urolithiasis and conditions associated therewith

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399599B1 (en) * 1999-10-13 2002-06-04 Novartis Ag Substituted 2-oxo-1,4-diazacycloalkanes
ECSP003707A (es) * 1999-10-13 2002-05-23 Novartis Ag Diazepanes
AR030817A1 (es) * 2000-10-02 2003-09-03 Novartis Ag Derivados de diazacicloalcanodiona
KR20030051882A (ko) 2000-11-28 2003-06-25 제넨테크, 인크. Ｌｆａ-1 대항제 화합물

Also Published As

Publication number Publication date
EP1590342A1 (en) 2005-11-02
PL376540A1 (pl) 2006-01-09
ECSP055917A (es) 2005-11-22
JP2006515335A (ja) 2006-05-25
KR20050095618A (ko) 2005-09-29
RU2347783C2 (ru) 2009-02-27
NO20053911L (no) 2005-10-24
US20060148780A1 (en) 2006-07-06
JP4644655B2 (ja) 2011-03-02
US7419976B2 (en) 2008-09-02
CO5580804A2 (es) 2005-11-30
PE20040941A1 (es) 2005-01-24
CA2509764A1 (en) 2004-08-05
NZ540867A (en) 2007-09-28
TW200418817A (en) 2004-10-01
MY141850A (en) 2010-07-16
MXPA05007846A (es) 2006-02-10
WO2004065382A1 (en) 2004-08-05
TWI311557B (en) 2009-07-01
BRPI0406884A (pt) 2006-01-03
AU2004205504B2 (en) 2007-09-20
RU2005126459A (ru) 2007-02-27
NO20053911D0 (no) 2005-08-22
AU2004205504A1 (en) 2004-08-05

Similar Documents

Publication Publication Date Title
EA200800924A1 (ru) Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера
EA200702080A1 (ru) Полициклическое карбомоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич
EA200600348A1 (ru) Новые соединения
PA8544901A1 (es) Derivados de oxazol
AR043466A1 (es) Proceso de un solo paso para la preparacion de derivados anticonvulsivos
CY1109532T1 (el) Παραγωγα ινδολο 1-οξεικου οξεος με pgd2 ανταγωνιστικη δραστικοτητα
CR8744A (es) Compuestos terapeuticos
AR047456A1 (es) Derivados de amidas, procesos para su preparacion y uso como insecticidas
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
PE20060570A1 (es) Compuestos de quinazolina e isoquinolina piperidilo sustituidos como inhibidores de fosfodiesterasa pde-10
AR031556A1 (es) Derivados de 3-(diarilmetilen)-8-azabiciclo[3.2.1] octano y composiciones farmaceuticas que los comprenden
AR058885A1 (es) Compuestos de piperidina 3,5-sustituidos
AR066972A1 (es) Derivados azapeptidicos
AR055171A1 (es) Derivados de carboxamida como antagonistas del receptor muscarinico
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
AR068376A1 (es) Amidas heterociclicas utiles para inhibir la via hedgehog.
AR053345A1 (es) Compuesto de 1,2,4 triazolo-5-ona como inhibidores de la transcriptasa inversa
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
AR040133A1 (es) Derivados de n-acilamino bencil eter
PA8589801A1 (es) Aminoalcoxiindoles
AR024494A1 (es) Proceso para la preparacion de derivados de ciclopentano sustituido y novedosas estructuras cristalinas de los mismos
AR054132A1 (es) Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasas
EA200600760A1 (ru) Новые соединения фенилпиридилпиперазина, способ их получения и фармацевтические композиции, содержащие их
EA200501530A1 (ru) Новые соединения бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
PA8581201A1 (es) Nuevos derivados de tiazol

Legal Events

Date Code Title Description
FB Suspension of granting procedure