AR042554A1 - Benzodioxepinas sustituidas - Google Patents
Benzodioxepinas sustituidasInfo
- Publication number
- AR042554A1 AR042554A1 ARP030104740A ARP030104740A AR042554A1 AR 042554 A1 AR042554 A1 AR 042554A1 AR P030104740 A ARP030104740 A AR P030104740A AR P030104740 A ARP030104740 A AR P030104740A AR 042554 A1 AR042554 A1 AR 042554A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently selected
- benzodioxepines
- alkoxyalkyl
- solvates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Las benzodioxepinas que se presentan, así como sus sales y solvatos fisiológicamente tolerables, son ligandos de los receptores 5HT1A y/o los receptores 5HT4 simultáneamente con fuerte inhibición de la recaptación de serotonina. Pueden ser utilizados para el tratamiento y la profilaxis de diversas enfermedades. Como por ejemplo isquiemia cerebral, desórdenes del sistemas nervioso, alimentarios y analgésicos. Reivindicación 1: Benzodioxepinas de la fórmula (1), en la cual: R1 está seleccionado, de forma independiente, de alquilo, (CH2)mOD, (CH2)mCN, (CH2)mCOR5 o (CH2)mCH2R5, donde m = 0 ó 1; R2 , R3 están seleccionados, de forma independiente, de H, alquilo C1-5; R4 está seleccionado, de forma independiente, de alquilo C1-5, heteroalquilo C1-5, alcoxi C1-5, alcoxialquilo C2-5, Hal, CN, COR5 u OH; R5 es OD, NH2, NHD o ND2; A es CnH2n con n = 2, 3 ó 4; B es CpH2p con p = 0, 1, 2, 3 ó 4; D está seleccionado, de forma independiente, de H, alquilo C1-5, alcoxialquilo C2-5, arilo o aralquilo; a, b son 0, 1 ó 2 y Hales F, Cl, Br o I, así como sus sales y solvatos fisiológicamente tolerables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02028596 | 2002-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042554A1 true AR042554A1 (es) | 2005-06-22 |
Family
ID=32668730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104740A AR042554A1 (es) | 2002-12-20 | 2003-12-19 | Benzodioxepinas sustituidas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7253202B2 (es) |
| EP (1) | EP1572685B1 (es) |
| JP (1) | JP4575167B2 (es) |
| KR (1) | KR20050084438A (es) |
| CN (1) | CN1729187A (es) |
| AR (1) | AR042554A1 (es) |
| AT (1) | ATE350379T1 (es) |
| AU (1) | AU2003289904B2 (es) |
| BR (1) | BR0317342A (es) |
| CA (1) | CA2511021C (es) |
| DE (1) | DE50306228D1 (es) |
| ES (1) | ES2280824T3 (es) |
| MX (1) | MXPA05006433A (es) |
| PL (1) | PL377325A1 (es) |
| WO (1) | WO2004058746A1 (es) |
| ZA (1) | ZA200505786B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7227023B2 (en) | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
| CN106243088B (zh) | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| PL443018A1 (pl) * | 2022-12-01 | 2024-06-03 | Uniwersytet Medyczny W Lublinie | Pochodne N-((9-chloro-3,4-dihydro-2H-benzo[b][1,4]dioksepin-7-ylo)metylo)-2-(6-fluoro-1H-indol-3-ylo)etano-1-aminy, sposób ich wytwarzania i zastosowanie |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3812150A (en) * | 1969-06-09 | 1974-05-21 | Frosst & Co | 3,3-disubstituted-benzodioxepins |
| US3700691A (en) * | 1969-06-09 | 1972-10-24 | Frosst & Co Charles E | 3,3-disubstituted-3,4-dihydrobenzodioxepins |
| US3944560A (en) * | 1972-05-01 | 1976-03-16 | Merck & Co., Inc. | 3-Hydroxy-3-(1,2,5-thiadiazolyloxyalkanol)-3,4-dihydro-2H-1,5-benzodioxepin products |
| GB2007656B (en) * | 1977-11-05 | 1982-05-19 | Pfizer Ltd | Therapeutic agents |
| DK166779B1 (da) * | 1983-12-14 | 1993-07-12 | Takeda Chemical Industries Ltd | 1,5-benzoxatiepinderivater eller farmaceutisk acceptable salte deraf, samt farmaceutisk praeparat indeholdende en saadan forbindelse |
| JP2865341B2 (ja) * | 1988-12-28 | 1999-03-08 | サントリー株式会社 | ベンゾオキサゼピン誘導体 |
| WO1996001816A1 (fr) | 1994-07-07 | 1996-01-25 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouveau derive de 2,3-dihydrobenzofuranne, son procede de production et son utilisation |
| JP3732554B2 (ja) * | 1994-07-07 | 2006-01-05 | 旭化成ファーマ株式会社 | 新規な２，３−ジヒドロベンゾフラン誘導体、その製造方法および用途 |
| DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
-
2003
- 2003-11-27 ES ES03782241T patent/ES2280824T3/es not_active Expired - Lifetime
- 2003-11-27 JP JP2004562656A patent/JP4575167B2/ja not_active Expired - Fee Related
- 2003-11-27 BR BR0317342-9A patent/BR0317342A/pt not_active Application Discontinuation
- 2003-11-27 AU AU2003289904A patent/AU2003289904B2/en not_active Ceased
- 2003-11-27 DE DE50306228T patent/DE50306228D1/de not_active Expired - Lifetime
- 2003-11-27 KR KR1020057011542A patent/KR20050084438A/ko not_active Application Discontinuation
- 2003-11-27 MX MXPA05006433A patent/MXPA05006433A/es not_active Application Discontinuation
- 2003-11-27 US US10/539,515 patent/US7253202B2/en not_active Expired - Fee Related
- 2003-11-27 WO PCT/EP2003/013373 patent/WO2004058746A1/de active IP Right Grant
- 2003-11-27 CA CA2511021A patent/CA2511021C/en not_active Expired - Fee Related
- 2003-11-27 PL PL377325A patent/PL377325A1/pl not_active Application Discontinuation
- 2003-11-27 AT AT03782241T patent/ATE350379T1/de not_active IP Right Cessation
- 2003-11-27 EP EP03782241A patent/EP1572685B1/de not_active Expired - Lifetime
- 2003-11-27 CN CNA200380106988XA patent/CN1729187A/zh active Pending
- 2003-12-19 AR ARP030104740A patent/AR042554A1/es unknown
-
2005
- 2005-07-19 ZA ZA200505786A patent/ZA200505786B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4575167B2 (ja) | 2010-11-04 |
| ZA200505786B (en) | 2006-04-26 |
| PL377325A1 (pl) | 2006-01-23 |
| ATE350379T1 (de) | 2007-01-15 |
| ES2280824T3 (es) | 2007-09-16 |
| CA2511021A1 (en) | 2004-07-15 |
| AU2003289904B2 (en) | 2009-12-10 |
| BR0317342A (pt) | 2005-11-08 |
| WO2004058746A1 (de) | 2004-07-15 |
| US7253202B2 (en) | 2007-08-07 |
| EP1572685B1 (de) | 2007-01-03 |
| KR20050084438A (ko) | 2005-08-26 |
| US20060167078A1 (en) | 2006-07-27 |
| AU2003289904A1 (en) | 2004-07-22 |
| EP1572685A1 (de) | 2005-09-14 |
| CA2511021C (en) | 2012-08-21 |
| MXPA05006433A (es) | 2005-08-19 |
| CN1729187A (zh) | 2006-02-01 |
| JP2006512380A (ja) | 2006-04-13 |
| DE50306228D1 (de) | 2007-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |