AR040445A1 - (r)-2-(4-amidinofenilaminometil)-1-metil-5-[1-(carboximetilamino)-1-(pirrolidinocarbonil)-etil]-bencimidazol cristalino, sus monoclorhidratos, procedimientos para su preparacion asi como su empleo como medicamento - Google Patents

(r)-2-(4-amidinofenilaminometil)-1-metil-5-[1-(carboximetilamino)-1-(pirrolidinocarbonil)-etil]-bencimidazol cristalino, sus monoclorhidratos, procedimientos para su preparacion asi como su empleo como medicamento

Info

Publication number
AR040445A1
AR040445A1 AR20030102210A ARP030102210A AR040445A1 AR 040445 A1 AR040445 A1 AR 040445A1 AR 20030102210 A AR20030102210 A AR 20030102210A AR P030102210 A ARP030102210 A AR P030102210A AR 040445 A1 AR040445 A1 AR 040445A1
Authority
AR
Argentina
Prior art keywords
procedures
methyl
preparation
well
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
AR20030102210A
Other languages
English (en)
Spanish (es)
Inventor
Linz Guenter Dr
Sieger Peter Dr
Werner Rall
Rolf Schmid
Schreiner Gunnar Dr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR040445A1 publication Critical patent/AR040445A1/es
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR20030102210A 2002-06-20 2003-06-20 (r)-2-(4-amidinofenilaminometil)-1-metil-5-[1-(carboximetilamino)-1-(pirrolidinocarbonil)-etil]-bencimidazol cristalino, sus monoclorhidratos, procedimientos para su preparacion asi como su empleo como medicamento Withdrawn AR040445A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10227666A DE10227666A1 (de) 2002-06-20 2002-06-20 (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
AR040445A1 true AR040445A1 (es) 2005-04-06

Family

ID=29719306

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102210A Withdrawn AR040445A1 (es) 2002-06-20 2003-06-20 (r)-2-(4-amidinofenilaminometil)-1-metil-5-[1-(carboximetilamino)-1-(pirrolidinocarbonil)-etil]-bencimidazol cristalino, sus monoclorhidratos, procedimientos para su preparacion asi como su empleo como medicamento

Country Status (9)

Country Link
EP (1) EP1529035A1 (ja)
JP (1) JP2006508037A (ja)
AR (1) AR040445A1 (ja)
AU (1) AU2003237945A1 (ja)
CA (1) CA2485545A1 (ja)
DE (1) DE10227666A1 (ja)
TW (1) TW200413329A (ja)
UY (1) UY27856A1 (ja)
WO (1) WO2004000818A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103403018B (zh) 2010-12-21 2015-08-19 医药公司（莱比锡）有限公司 胰蛋白酶样丝氨酸蛋白酶抑制剂,它们的制备以及作为凝结因子IIa和Xa的选择性抑制剂的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19962329A1 (de) * 1999-12-23 2001-06-28 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
TW200413329A (en) 2004-08-01
CA2485545A1 (en) 2003-12-31
JP2006508037A (ja) 2006-03-09
EP1529035A1 (de) 2005-05-11
WO2004000818A1 (de) 2003-12-31
DE10227666A1 (de) 2004-01-08
UY27856A1 (es) 2003-12-31
AU2003237945A1 (en) 2004-01-06

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal