AU2003237945A1 - Crystalline (r)-2-(4-amidinophenylaminomethyl)-1-methyl-5-(1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl)-benzimidazole, and the use thereof as antithrombotic agents - Google Patents

Crystalline (r)-2-(4-amidinophenylaminomethyl)-1-methyl-5-(1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl)-benzimidazole, and the use thereof as antithrombotic agents

Info

Publication number
AU2003237945A1
AU2003237945A1 AU2003237945A AU2003237945A AU2003237945A1 AU 2003237945 A1 AU2003237945 A1 AU 2003237945A1 AU 2003237945 A AU2003237945 A AU 2003237945A AU 2003237945 A AU2003237945 A AU 2003237945A AU 2003237945 A1 AU2003237945 A1 AU 2003237945A1
Authority
AU
Australia
Prior art keywords
amidinophenylaminomethyl
pyrrolidinocarbonyl
carboxymethylamino
benzimidazole
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003237945A
Inventor
Guenter Linz
Werner Rall
Rolf Schmid
Gunnar Schreiner
Peter Sieger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2003237945A1 publication Critical patent/AU2003237945A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
AU2003237945A 2002-06-20 2003-06-16 Crystalline (r)-2-(4-amidinophenylaminomethyl)-1-methyl-5-(1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl)-benzimidazole, and the use thereof as antithrombotic agents Abandoned AU2003237945A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10227666.8 2002-06-20
DE10227666A DE10227666A1 (en) 2002-06-20 2002-06-20 (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) ethyl] benzimidazole, its monohydrochloride, process for its preparation and use as a medicament
PCT/EP2003/006317 WO2004000818A1 (en) 2002-06-20 2003-06-16 Crystalline (r)-2-(4-amidinophenylaminomethyl)-1-methyl-5-(1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl)-benzimidazole, and the use thereof as antithrombotic agents

Publications (1)

Publication Number Publication Date
AU2003237945A1 true AU2003237945A1 (en) 2004-01-06

Family

ID=29719306

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003237945A Abandoned AU2003237945A1 (en) 2002-06-20 2003-06-16 Crystalline (r)-2-(4-amidinophenylaminomethyl)-1-methyl-5-(1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl)-benzimidazole, and the use thereof as antithrombotic agents

Country Status (9)

Country Link
EP (1) EP1529035A1 (en)
JP (1) JP2006508037A (en)
AR (1) AR040445A1 (en)
AU (1) AU2003237945A1 (en)
CA (1) CA2485545A1 (en)
DE (1) DE10227666A1 (en)
TW (1) TW200413329A (en)
UY (1) UY27856A1 (en)
WO (1) WO2004000818A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2655399B1 (en) 2010-12-21 2017-09-27 The Medicines Company (Leipzig) GmbH Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19962329A1 (en) * 1999-12-23 2001-06-28 Boehringer Ingelheim Pharma New substituted 2-(phenylaminomethyl)-benzimidazoles, used as thrombin inhibitors, serine protease inhibitors, antithrombotic agents and intermediates

Also Published As

Publication number Publication date
TW200413329A (en) 2004-08-01
UY27856A1 (en) 2003-12-31
DE10227666A1 (en) 2004-01-08
JP2006508037A (en) 2006-03-09
AR040445A1 (en) 2005-04-06
CA2485545A1 (en) 2003-12-31
EP1529035A1 (en) 2005-05-11
WO2004000818A1 (en) 2003-12-31

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase