UY27856A1 - (R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5. (1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL) -BANCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR THE PREPARATION AS WELL AS THE EMPLOYMENT - Google Patents

(R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5. (1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL) -BANCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR THE PREPARATION AS WELL AS THE EMPLOYMENT

Info

Publication number
UY27856A1
UY27856A1 UY27856A UY27856A UY27856A1 UY 27856 A1 UY27856 A1 UY 27856A1 UY 27856 A UY27856 A UY 27856A UY 27856 A UY27856 A UY 27856A UY 27856 A1 UY27856 A1 UY 27856A1
Authority
UY
Uruguay
Prior art keywords
methyl
preparation
well
crystalline
pirrolidinocarbonil
Prior art date
Application number
UY27856A
Other languages
Spanish (es)
Inventor
Dr Dr Guenter Linz
Dr Peter Sieger
Dr Gunnar Schreiner
Werner Rall
Rolf Schmid
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY27856A1 publication Critical patent/UY27856A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

El objeto de la presente invención son las formas cristalinas de los compuestos (R)-2-(4-amidinofenilaminometil)-1-metil-5-(carboximetilamino)-1-(pirrolidinocarbonil)-etil)-bencimidazol y sus monoclorhidratos, procedimientos para su preparación así como su empleo como medicamentos.The object of the present invention are the crystalline forms of the compounds (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- (carboxymethylamino) -1- (pyrrolidinocarbonyl) -ethyl) -benzimidazole and its monohydrochlorides, processes for its preparation as well as its use as medicines.

UY27856A 2002-06-20 2003-06-18 (R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5. (1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL) -BANCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR THE PREPARATION AS WELL AS THE EMPLOYMENT UY27856A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10227666A DE10227666A1 (en) 2002-06-20 2002-06-20 (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) ethyl] benzimidazole, its monohydrochloride, process for its preparation and use as a medicament

Publications (1)

Publication Number Publication Date
UY27856A1 true UY27856A1 (en) 2003-12-31

Family

ID=29719306

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27856A UY27856A1 (en) 2002-06-20 2003-06-18 (R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5. (1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL) -BANCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR THE PREPARATION AS WELL AS THE EMPLOYMENT

Country Status (9)

Country Link
EP (1) EP1529035A1 (en)
JP (1) JP2006508037A (en)
AR (1) AR040445A1 (en)
AU (1) AU2003237945A1 (en)
CA (1) CA2485545A1 (en)
DE (1) DE10227666A1 (en)
TW (1) TW200413329A (en)
UY (1) UY27856A1 (en)
WO (1) WO2004000818A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2655399B1 (en) 2010-12-21 2017-09-27 The Medicines Company (Leipzig) GmbH Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19962329A1 (en) * 1999-12-23 2001-06-28 Boehringer Ingelheim Pharma New substituted 2-(phenylaminomethyl)-benzimidazoles, used as thrombin inhibitors, serine protease inhibitors, antithrombotic agents and intermediates

Also Published As

Publication number Publication date
TW200413329A (en) 2004-08-01
DE10227666A1 (en) 2004-01-08
JP2006508037A (en) 2006-03-09
AR040445A1 (en) 2005-04-06
CA2485545A1 (en) 2003-12-31
EP1529035A1 (en) 2005-05-11
AU2003237945A1 (en) 2004-01-06
WO2004000818A1 (en) 2003-12-31

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150126