AR040445A1 - (R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5- [1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL] -BENCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR ITS PREPARATION AS WELL AS USE - Google Patents

(R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5- [1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL] -BENCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR ITS PREPARATION AS WELL AS USE

Info

Publication number
AR040445A1
AR040445A1 AR20030102210A ARP030102210A AR040445A1 AR 040445 A1 AR040445 A1 AR 040445A1 AR 20030102210 A AR20030102210 A AR 20030102210A AR P030102210 A ARP030102210 A AR P030102210A AR 040445 A1 AR040445 A1 AR 040445A1
Authority
AR
Argentina
Prior art keywords
procedures
methyl
preparation
well
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
AR20030102210A
Other languages
Spanish (es)
Inventor
Linz Guenter Dr
Sieger Peter Dr
Werner Rall
Rolf Schmid
Schreiner Gunnar Dr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR040445A1 publication Critical patent/AR040445A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El objeto de la presente invención son las formas cristalinas de los compuestos (R)-2-(4-amidinofenilaminometil)-1-metil-5-[1-(carboximetilamino)-1-(pirrolidinocarbonil)-etil]-bencimidazol y sus mono-clorohidratos, procedimientos para su preparación así como su empleo como medicamentos útiles para profilaxis y terapia de la trombosis, embolia pulmonar, enfermedad coronaria.The object of the present invention are the crystalline forms of the compounds (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) -ethyl] -benzimidazole and their mono-chlorohydrates, procedures for their preparation as well as their use as useful medications for prophylaxis and therapy of thrombosis, pulmonary embolism, coronary heart disease.

AR20030102210A 2002-06-20 2003-06-20 (R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5- [1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL] -BENCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR ITS PREPARATION AS WELL AS USE Withdrawn AR040445A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10227666A DE10227666A1 (en) 2002-06-20 2002-06-20 (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) ethyl] benzimidazole, its monohydrochloride, process for its preparation and use as a medicament

Publications (1)

Publication Number Publication Date
AR040445A1 true AR040445A1 (en) 2005-04-06

Family

ID=29719306

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102210A Withdrawn AR040445A1 (en) 2002-06-20 2003-06-20 (R) -2- (4-AMIDINOPHENYLAMINOMETIL) -1-METHYL-5- [1- (CARBOXIMETHYLAMINE) -1- (PIRROLIDINOCARBONIL) -ETIL] -BENCIMIDAZOL CRYSTALLINE, ITS MONOCLORHYDRATES, PROCEDURES FOR ITS PREPARATION AS WELL AS USE

Country Status (9)

Country Link
EP (1) EP1529035A1 (en)
JP (1) JP2006508037A (en)
AR (1) AR040445A1 (en)
AU (1) AU2003237945A1 (en)
CA (1) CA2485545A1 (en)
DE (1) DE10227666A1 (en)
TW (1) TW200413329A (en)
UY (1) UY27856A1 (en)
WO (1) WO2004000818A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2655399B1 (en) 2010-12-21 2017-09-27 The Medicines Company (Leipzig) GmbH Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19962329A1 (en) * 1999-12-23 2001-06-28 Boehringer Ingelheim Pharma New substituted 2-(phenylaminomethyl)-benzimidazoles, used as thrombin inhibitors, serine protease inhibitors, antithrombotic agents and intermediates

Also Published As

Publication number Publication date
TW200413329A (en) 2004-08-01
UY27856A1 (en) 2003-12-31
DE10227666A1 (en) 2004-01-08
JP2006508037A (en) 2006-03-09
CA2485545A1 (en) 2003-12-31
EP1529035A1 (en) 2005-05-11
AU2003237945A1 (en) 2004-01-06
WO2004000818A1 (en) 2003-12-31

Similar Documents

Publication Publication Date Title
PA8680701A1 (en) OXINDOL DERIVATIVES
ECSP088821A (en) THIOXANTINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MPO
ECSP034809A (en) CICLOBUTENO-1,2-DIONAS 3,4-DISUSTITUTED AS LIGANDS OF THE CXC CHEMOCINE RECEIVER
CR8744A (en) THERAPEUTIC COMPOUNDS
CO2021013183A2 (en) Pesticide-active diazine-amide compounds
CO2022005257A2 (en) Pesticide-active condensed bicyclic heteroaromatic compounds
ECSP055640A (en) PIRAZOL COMPOSITIONS USEFUL AS INHIBITORS OF GSK-3
CO2021013350A2 (en) Pesticide-active diazine-amide compounds
CR9716A (en) BENCIMIDAZOLS REPLACED AS CINASA INHIBITORS
UY28514A1 (en) NEW COMPOUNDS
CR20140215A (en) CYCLOPENTA (D) PYRIMIDINS AS INHIBITORS OF THE PROTEIN CINASA AKT
ECSP088121A (en) PIRROLO DERIVATIVES [2,3-B] PYRIDINE AS PROTEIN KINASE INHIBITORS
ECSP056192A (en) 3-FLUORO-PIPERIDINS AS ANTAGONISTS OF NMDA / NR2B
ECSP045407A (en) BENZAZOLES SUBSTITUTED AND THE USE OF THE SAME AS INHIBITORS OF QUINASA RAF
PA8557401A1 (en) PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS
UY29093A1 (en) DERIVATIVES OF 4-OXO-3. 4-DIHIDROQUINAZOLIN-6-CARBOXAMIDA, B-RAF INHIBITORS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION PROCESSES AND APPLICATIONS.
PA8748101A1 (en) BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES
ECSP109937A (en) PYRIMIDIL CYCLOPENTANS AS INHIBITORS OF THE PROTEIN QUINASA AKT.
UY29246A1 (en) NEW COMPOUNDS
PA8724201A1 (en) PIRIDIN [3,4B] PIRAZINONAS
RS52245B (en) Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
NI201000085A (en) DERIVATIVES BIS - (SULFONYLAMINE) IN THERAPY 066.
CR8497A (en) DERIVATIVES OF AZEPINOINDOL AS PHARMACEUTICAL AGENTS
UY38623A (en) DIAZINE-AMIDE COMPOUNDS ACTIVE AS PESTICIDES
PE20221724A1 (en) ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) DEGRADATION

Legal Events

Date Code Title Description
FA Abandonment or withdrawal