TW200521122A
(en)
*
|
2003-07-24 |
2005-07-01 |
Fujiyakuhin Co Ltd |
Method of preparing 1,2,4-triazole compounds and intermediates thereof
|
US20060189811A1
(en)
*
|
2004-07-23 |
2006-08-24 |
Fujiyakuhin Co., Ltd. |
Process for producing 1,2,4-triazole compound and intermediate therefor
|
JP2008545627A
(en)
*
|
2005-05-09 |
2008-12-18 |
タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド |
How to treat nephrolithiasis
|
CA2617248C
(en)
*
|
2005-08-03 |
2015-09-29 |
Tap Pharmaceutical Products, Inc. |
Methods for treating hypertension
|
JPWO2007043401A1
(en)
*
|
2005-10-07 |
2009-04-16 |
キッセイ薬品工業株式会社 |
Nitrogen-containing heterocyclic compound and pharmaceutical composition containing the same
|
EP2036561B1
(en)
*
|
2006-06-22 |
2017-05-10 |
Nippon Chemiphar Co., Ltd. |
Agent for overcoming resistance to anti-cancer agent
|
EP2050467B1
(en)
*
|
2006-07-19 |
2014-09-10 |
Nippon Medical School Foundation |
Therapeutic agent for amyotrophic lateral sclerosis
|
US20090124623A1
(en)
*
|
2006-11-13 |
2009-05-14 |
Christopher Lademacher |
Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
|
CN101677999A
(en)
*
|
2006-11-13 |
2010-03-24 |
塔普医药产品公司 |
Methods for preserving renal function using xanthine oxidoreductase inhibitors
|
WO2008089296A1
(en)
*
|
2007-01-19 |
2008-07-24 |
Takeda Pharmaceuticals North America |
Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents
|
JO2784B1
(en)
*
|
2007-10-18 |
2014-03-15 |
شركة جانسين فارماسوتيكا ان. في |
1,3,5-trisubstitued triazole derivative
|
EP2217577B1
(en)
|
2007-11-27 |
2014-08-06 |
Ardea Biosciences, Inc. |
Novel compounds and compositions and methods of use
|
EP2165705A1
(en)
|
2008-09-18 |
2010-03-24 |
Centre National de la Recherche Scientifique (CNRS) |
Use of a compound capable of reducing the uric acid level for the prevention and/or the treatment of lung inflammation and fibrosis
|
US20100311756A1
(en)
*
|
2009-01-22 |
2010-12-09 |
Takeda Pharmaceuticals North America, Inc. |
Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
|
KR101797936B1
(en)
|
2010-09-10 |
2017-11-15 |
다케다 파마슈티칼스 유에스에이, 인코포레이티드 |
Methods for concomitant treatment of theophylline and febuxostat
|
WO2012060308A1
(en)
*
|
2010-11-01 |
2012-05-10 |
株式会社 三和化学研究所 |
Medicine for preventing and treating renal dysfunction
|
US9302996B2
(en)
|
2010-12-17 |
2016-04-05 |
Mitsubishi Tanabe Pharma Corporation |
Continuous arycyclic compound
|
WO2012118485A1
(en)
|
2011-03-01 |
2012-09-07 |
Empire Technology Development Llc |
Temperature controlled variable reflectivity coatings
|
RU2476428C1
(en)
*
|
2011-09-01 |
2013-02-27 |
Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" |
Method of producing 5-amino-3-aminomethyl-1,2,4-triazole dihydrochloride
|
ES2690315T3
(en)
|
2012-06-15 |
2018-11-20 |
Mitsubishi Tanabe Pharma Corporation |
Imidazole and triazole compounds as DGAT-1 inhibitors
|
AU2013293973B2
(en)
*
|
2012-07-25 |
2017-04-06 |
Fujiyakuhin Co., Ltd. |
4-[5-(Pyridin-4-yl)-1H-1,2,4-Triazol-3-yl]Pyridine-2-Carbonitrile Crystalline Polymorph and Production Method Therefor
|
NZ702797A
(en)
*
|
2012-07-25 |
2017-03-31 |
Fujiyakuhin Co Ltd |
Method for producing 4-[5-(pyridin-4-yl)-1h-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and intermediate thereof
|
CN103724329B
(en)
*
|
2013-12-23 |
2015-02-18 |
济南百诺医药科技开发有限公司 |
Preparation method of 4-[5-(pyridyl-4-yl)-1H-[1,2,4]triazolyl-3-yl]pyridyl-2-formonitrile
|
CN104042577B
(en)
*
|
2014-06-13 |
2016-08-24 |
安徽省逸欣铭医药科技有限公司 |
A kind of stable Topiroxostat tablet and preparation method thereof
|
CN105315260A
(en)
*
|
2014-07-29 |
2016-02-10 |
北京海步医药科技股份有限公司 |
Topiroxostat monohydrate crystal form and preparation method thereof
|
CN105348264B
(en)
*
|
2014-08-18 |
2018-01-16 |
上海医药工业研究院 |
A kind of his synthetic method of support pyrrole department
|
CN105367490B
(en)
*
|
2014-08-18 |
2019-01-04 |
上海医药工业研究院 |
Synthesis support his new intermediate and preparation method thereof of pyrrole department
|
CN104151297B
(en)
*
|
2014-08-27 |
2016-03-16 |
王庆本 |
The preparation method of 4-[5-(pyridin-4-yl)-1H-[1,2,4] triazole-3-base] pyridine-2-formonitrile HCN
|
JP6684264B2
(en)
*
|
2015-02-17 |
2020-04-22 |
株式会社三和化学研究所 |
Medicine for the prevention or treatment of heart failure
|
EP3263109B1
(en)
|
2015-02-24 |
2020-06-17 |
National University Corporation Tottori University |
Drug for preventing and/or treating dementia
|
CN107531677A
(en)
*
|
2015-02-25 |
2018-01-02 |
法尔玛赞公司 |
Method for preparing Topiroxostat and its intermediate
|
CN105693699B
(en)
*
|
2015-03-30 |
2019-06-18 |
苏州晶云药物科技股份有限公司 |
Hold in the palm his crystal form and preparation method thereof of pyrrole department
|
CN104910068B
(en)
*
|
2015-04-24 |
2017-07-14 |
南京医科大学 |
A kind of synthetic method of the tosilate of 2 cyano group isonicotinic acid hydrazide 1.5
|
CN106279111A
(en)
*
|
2015-05-12 |
2017-01-04 |
北京济美堂医药研究有限公司 |
His new method of a kind of refined torr pyrrole department
|
CN104961730B
(en)
*
|
2015-06-18 |
2017-05-17 |
山东金城医药化工股份有限公司 |
Novel topiroxostat crystal form and method for preparing same
|
CN105130958B
(en)
*
|
2015-08-31 |
2017-10-31 |
济南康和医药科技有限公司 |
The preparation technology of 5 (pyridine radicals of 2 cyano group 4) 3 (4 pyridine radicals) 1,2,4 triazoles
|
CN105294656A
(en)
*
|
2015-10-10 |
2016-02-03 |
大道隆达(北京)医药科技发展有限公司 |
Preparation process and method for topiroxostat
|
CN106336399A
(en)
*
|
2015-11-03 |
2017-01-18 |
江苏悦兴药业有限公司 |
Preparation method of Topiroxostat process impurity
|
CN105294584A
(en)
*
|
2015-11-30 |
2016-02-03 |
中国医科大学 |
1-substituted phenyl-1H-1,2,3-triazole compound as well as preparation method and application thereof
|
CN105399732A
(en)
*
|
2015-12-07 |
2016-03-16 |
青岛正大海尔制药有限公司 |
Preparation method of topiroxostat
|
CN106008465A
(en)
*
|
2016-03-16 |
2016-10-12 |
江苏悦兴药业有限公司 |
Topiroxostat impurity synthesis method
|
CN108250183A
(en)
*
|
2016-12-29 |
2018-07-06 |
北京诚济制药有限公司 |
A kind of preparation method of the Topiroxostat of high-purity
|
CN109721586B
(en)
*
|
2017-10-27 |
2021-03-02 |
中国医科大学 |
5-benzyl-3-pyridyl-1H-1, 2, 4-triazole compound and preparation method and application thereof
|
CN107652271B
(en)
*
|
2017-11-06 |
2020-06-16 |
上海中拓医药科技有限公司 |
Preparation method of topiroxostat crystal form I
|
CN108017619B
(en)
*
|
2017-12-06 |
2020-08-11 |
成都惟邦药业有限公司 |
Topiroxostat impurity and preparation method thereof
|
CN113354616B
(en)
*
|
2020-03-05 |
2024-03-26 |
中国医学科学院药物研究所 |
Diaryl-1, 2, 4-triazole compound and preparation method and pharmaceutical application thereof
|
CN113666909A
(en)
*
|
2020-05-14 |
2021-11-19 |
鲁南制药集团股份有限公司 |
Preparation method of topiroxostat
|
CN114773262A
(en)
*
|
2022-05-19 |
2022-07-22 |
兄弟科技股份有限公司 |
Synthesis method of 2-cyano-4-pyridine carboxylic acid methyl ester
|