AU2003279366A1 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
AU2003279366A1
AU2003279366A1 AU2003279366A AU2003279366A AU2003279366A1 AU 2003279366 A1 AU2003279366 A1 AU 2003279366A1 AU 2003279366 A AU2003279366 A AU 2003279366A AU 2003279366 A AU2003279366 A AU 2003279366A AU 2003279366 A1 AU2003279366 A1 AU 2003279366A1
Authority
AU
Australia
Prior art keywords
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003279366A
Inventor
Steven Coulton
Roderick Alan Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB0225938.0A priority Critical patent/GB0225938D0/en
Priority to GB0225938.0 priority
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to PCT/EP2003/012406 priority patent/WO2004041807A1/en
Publication of AU2003279366A1 publication Critical patent/AU2003279366A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
AU2003279366A 2002-11-06 2003-11-04 Novel compounds Abandoned AU2003279366A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB0225938.0A GB0225938D0 (en) 2002-11-06 2002-11-06 Novel compounds
GB0225938.0 2002-11-06
PCT/EP2003/012406 WO2004041807A1 (en) 2002-11-06 2003-11-04 Novel compounds

Publications (1)

Publication Number Publication Date
AU2003279366A1 true AU2003279366A1 (en) 2004-06-07

Family

ID=9947352

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003279366A Abandoned AU2003279366A1 (en) 2002-11-06 2003-11-04 Novel compounds

Country Status (3)

Country Link
AU (1) AU2003279366A1 (en)
GB (1) GB0225938D0 (en)
WO (1) WO2004041807A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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GB0127145D0 (en) 2001-11-10 2002-01-02 Smithkline Beecham Compounds
PT1751111E (en) 2004-03-01 2015-04-01 Actelion Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
FR2896798A1 (en) * 2006-01-27 2007-08-03 Sanofi Aventis Sa Sulfonamide derivatives, their preparation and their therapeutic application
WO2008008517A2 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
DE602007009284D1 (en) * 2006-09-29 2010-10-28 Actelion Pharmaceuticals Ltd 3-AZA-BICYCLOÄ3.1.0ÜHEXANDERIVATE
AT496043T (en) 2006-12-01 2011-02-15 Actelion Pharmaceuticals Ltd 3-heteroaryl (amino or amido) -1- (biphenyl and phenylthiazolyl) carbonyl piperdin derivatives as orexin receptor inhibitors
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
TW200833328A (en) 2006-12-28 2008-08-16 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.1.0]hexane derivatives
CL2008000836A1 (en) 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Compounds derived from thiazolidine, orexin receptor antagonists; pharmaceutical composition comprising them; and its use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's, Parkinson's, pain, among others.
WO2008150364A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
PT2152690E (en) 2007-05-23 2012-03-30 Merck Sharp & Dohme Pyridyl piperidine orexin receptor antagonists
BRPI0814593A2 (en) 2007-07-27 2015-01-20 Actelion Pharmaceuticals Ltd Compound, pharmaceutical composition containing and use of the compound.
CN101874030B (en) 2007-09-24 2012-11-14 埃科特莱茵药品有限公司 Pyrrolidines and piperidines as orexin receptor antagonists
MX2010008993A (en) 2008-02-21 2010-09-07 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[2.2.1]heptane derivatives.
EP2608787B1 (en) 2010-08-24 2019-11-20 Idorsia Pharmaceuticals Ltd Proline sulfonamide derivatives as orexin receptor antagonists
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme 2-pyridyloxy-4-nitrile orexin receptor antagonists
SG11201404738QA (en) 2012-02-07 2014-10-30 Eolas Therapeutics Inc Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
KR101689093B1 (en) 2012-06-04 2016-12-22 액테리온 파마슈티칼 리미티드 Benzimidazole-proline derivatives
EA201500399A1 (en) 2012-10-10 2015-09-30 Актелион Фармасьютиклз Лтд. Orexin receptor antagonists, which are representing derivatives of [orto-bi- (hetero) aryl] - [2- (meta-bi- (hetero) aryl) pyrrolidin-1-il] methanon
CN105051040A (en) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 Azetidine amide derivatives as orexin receptor antagonists
ES2651475T3 (en) 2013-12-03 2018-01-26 Idorsia Pharmaceuticals Ltd Crystalline form of (S) - (2- (6-chloro-7-methyl-1H-benzo [d] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2- (2H- 1,2,3-triazol-2-yl) phenyl) methanone and its use as orexin receptor antagonists
EP3077390B1 (en) 2013-12-03 2017-09-13 Idorsia Pharmaceuticals Ltd Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
EP3077391B1 (en) 2013-12-04 2018-08-15 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
JP6663909B2 (en) 2014-08-13 2020-03-13 エオラス セラピューティクス, インコーポレイテッド Difluoropyrrolidine as an orexin receptor modulator
WO2017139603A1 (en) 2016-02-12 2017-08-17 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9612884D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
AU8357198A (en) * 1997-07-24 1999-02-16 Mitsubishi-Tokyo Pharmaceuticals, Inc. Aminocycloalkane compounds
EP1242081A4 (en) * 1999-09-30 2004-07-21 Smithkline Beecham Corp Caspases and apoptosis
US6677354B2 (en) * 2000-06-16 2004-01-13 Smithkline Beecham P.L.C. Piperdines for use as orexin receptor antagonists
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
ES2234929T3 (en) * 2000-11-28 2005-07-01 Smithkline Beecham Plc Morfoline derivatives as antagonists of orexine receptors.
HU0400048A3 (en) * 2001-05-05 2008-10-28 Smithkline Beecham Plc N-aroyl cyclic amines and pharmaceutical compositions containing them
WO2003028641A2 (en) * 2001-10-01 2003-04-10 Taisho Pharmaceutical Co., Ltd. Mch receptor antagonists
GB0127145D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Compounds

Also Published As

Publication number Publication date
GB0225938D0 (en) 2002-12-11
WO2004041807A1 (en) 2004-05-21

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase