AR038524A1 - Derivados de fenalenona, procedimiento para su preparacion y utilizacion de los mismos - Google Patents

Derivados de fenalenona, procedimiento para su preparacion y utilizacion de los mismos

Info

Publication number
AR038524A1
AR038524A1 ARP030100503A ARP030100503A AR038524A1 AR 038524 A1 AR038524 A1 AR 038524A1 AR P030100503 A ARP030100503 A AR P030100503A AR P030100503 A ARP030100503 A AR P030100503A AR 038524 A1 AR038524 A1 AR 038524A1
Authority
AR
Argentina
Prior art keywords
formula
alkenyl
alkyl
branched
linear
Prior art date
Application number
ARP030100503A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of AR038524A1 publication Critical patent/AR038524A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Furan Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Derivados de fenalenona de fórmula (1) y (2), procedimiento para su preparación y utilización de los mismos. Se refiere a derivados de fenalenona, a su preparación por fermentación del microorganismo Penicillium herquei Bainer & Sartory, DMS 14142, así como por derivatización de las fenalenonas formadas durante la fermentación, y a la utilización de derivados de fenalenona como medicamentos, por ejemplo contra enfermedades tumorales, infecciones bacterianas y/o micosis, y enfermedades reumáticas. Reivindicación 1: Compuesto de la fórmula (3) o un compuesto de la fórmula (4) en las cuales X significa, o bien un grupo de la fórmula (5) o de la fórmula (6) y R1 y, en caso de existir, R2, significan al mismo tiempo 1.0 H, o 2.0 alquilo(C1-6), alquenilo(C2-6) o alquinilo(C2-6), en donde alquilo, alquenilo o alquinilo son lineales o ramificados y están sustituidos, eventualmente una o dos veces, con: 2.1 -OH, 2.2 =O, 2.3 -O-alquilo (C1-6), en donde alquilo es lineal o ramificado, 2.4 -O-alquenilo (C2-6), en donde alquenilo es lineal o ramificado, 2.5 -arilo, 2.6 -NH-alquilo (C1-6), en donde alquilo es lineal o ramificado, 2.7 -NH-alquenilo (C2-6), en donde alquenilo es lineal o ramificado, 2.8 -NH2 ó 2.9 halógeno, en donde los sustituyentes 2.1 a 2.9 aún pueden seguir estando sustituidos con funciones -CN, -amida u -oxima, y/o una forma estereoisómera del compuesto de la fórmula (3) o de la fórmula (4) y/o mezclas de esta forma en cualquier relación, y/o una sal fisiológicamente tolerable del compuesto de la fórmula (3) o (4).
ARP030100503A 2002-02-18 2003-02-14 Derivados de fenalenona, procedimiento para su preparacion y utilizacion de los mismos AR038524A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10206849A DE10206849A1 (de) 2002-02-18 2002-02-18 Phenalenon-Derivate, Verfahren zur Herstellung und Verwendung derselben

Publications (1)

Publication Number Publication Date
AR038524A1 true AR038524A1 (es) 2005-01-19

Family

ID=27674733

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100503A AR038524A1 (es) 2002-02-18 2003-02-14 Derivados de fenalenona, procedimiento para su preparacion y utilizacion de los mismos

Country Status (10)

Country Link
EP (1) EP1478731A1 (es)
JP (1) JP2005517710A (es)
AR (1) AR038524A1 (es)
AU (1) AU2003210205B2 (es)
BR (1) BR0307733A (es)
CA (1) CA2476618A1 (es)
DE (1) DE10206849A1 (es)
MX (1) MXPA04007918A (es)
PE (1) PE20030904A1 (es)
WO (1) WO2003068946A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113725A1 (ja) * 2009-03-30 2010-10-07 日本水産株式会社 三環性縮合複素環化合物、その製造方法および用途
WO2011009899A2 (en) * 2009-07-22 2011-01-27 Instituto Biomar, S.A. Phenalenones as antitumoral agents
FR2987622B1 (fr) * 2012-03-02 2016-01-15 Centre Nat Rech Scient Composes oxo-phenalenes, leur preparation et utilisation dans les domaines des materiaux et therapeutique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2812510B2 (ja) * 1989-10-06 1998-10-22 日清製油株式会社 アトロベネチンの用途
AU2864100A (en) * 1999-02-01 2000-08-18 Cytovia, Inc. Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding products

Also Published As

Publication number Publication date
DE10206849A1 (de) 2005-07-28
WO2003068946A1 (de) 2003-08-21
BR0307733A (pt) 2005-01-25
PE20030904A1 (es) 2003-11-18
JP2005517710A (ja) 2005-06-16
AU2003210205A1 (en) 2003-09-04
CA2476618A1 (en) 2003-08-21
MXPA04007918A (es) 2004-11-26
AU2003210205B2 (en) 2007-06-14
EP1478731A1 (de) 2004-11-24

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FA Abandonment or withdrawal