AR038287A1 - Composicion farmaceutica que comprende una glitazona y un acido 4-oxobutanoico y uso de la misma para el tratamiento de la diabetes - Google Patents
Composicion farmaceutica que comprende una glitazona y un acido 4-oxobutanoico y uso de la misma para el tratamiento de la diabetesInfo
- Publication number
- AR038287A1 AR038287A1 ARP030100058A ARP030100058A AR038287A1 AR 038287 A1 AR038287 A1 AR 038287A1 AR P030100058 A ARP030100058 A AR P030100058A AR P030100058 A ARP030100058 A AR P030100058A AR 038287 A1 AR038287 A1 AR 038287A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- aryl
- alkyl
- radical
- groups
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Una composición farmacéutica, que comprende, como principios activos, (i) al menos una glitazona y (ii) al menos un compuesto de la fórmula (1), en asociación con uno o varios excipientes aceptables para uso farmacéutico, donde el compuesto de la fórmula (1) se define de la siguiente manera: los grupos A y B se seleccionan, independientemente entre sí, entre: un grupo arilo mono, bi o tricíclico que contiene entre 6 y 14 átomos de carbono; un grupo heteroaromático seleccionado entre grupos piridilo, pirimidilo, pirrolilo, furilo y tienilo; un grupo alquilo que contiene entre 1 y 14 átomos de carbono; un grupo cicloalquilo que contiene entre 5 y 8 átomos de carbono; un grupo heterocíclico saturado seleccionado entre grupos tetrahidrofurilo, tetrahidropiranilo, piperidilo y pirrolidinilo; donde los grupos A y B pueden llevar entre 1 y 3 sustituyentes seleccionados entre un grupo (C1-6) alquilo, (C1-6) alcoxi, (C6-14) arilo, heteroarilo seleccionado entre piridilo, pirimidilo, pirrolilo, furilo y tienilo, un grupo (C6-14) aril (C1-6) alquilo, (C6-14)aril(C1-6)alquil(C6-14)arilo, un halógeno, un grupo trifluorometilo, trifluorometoxi, ciano, hidroxilo, nitro, amino, carboxilo, (C1-6)alcoxicarbonilo, carbamoílo, (C1-6)alquilsulfonilo, sulfoamino, (C1-6)alquilsulfonilamino, sulfamoílo, (C1-6)alquilcarbonilamino; o dos de los sustituyentes forman un grupo metilendioxi, un solvato del mismo o una sal de este ácido. Reivindicación 2: La composición acorde con la reivindicación 1, caracterizada porque la glitazona es un compuesto que presenta la fórmula general (2), donde: E representa una estructura aromática monocíclica, bicíclica o tricíclica de base hidrocarbonada que puede incluir uno o varios heteroátomos, donde esta estructura puede estar opcionalmente sustituida con al menos un radical (C1-6) alquilo o acetilo o puede formar un anillo de 5 ó 6 miembros con el radical metileno unido a Y; N es igual a 1, 2 ó 3, Y representa un átomo de oxígeno, una función -NHCO-, -CONH- o -CO-; y F representa un grupo amino o un grupo de base hidrocarbonada aromático o no aromático, cíclico o bicíclico, que contiene optativamente un heteroátomo seleccionado entre oxígeno y nitrógeno, donde los grupos amino y de base hidrocarbonada pueden contener al menos una sustitución seleccionada entre un radical (C1-6) alquilo, un átomo de halógeno, un radical arilo o heteroarilo, un radical acetilo y un radical trifluorometilo, o una sal aceptable para uso farmacéutico de la misma.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0200335A FR2834640B1 (fr) | 2002-01-11 | 2002-01-11 | Composition pharmaceutique comprenant une glitazone et un acide 4-oxobutanoique et son utilisation pour traiter le diabete |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038287A1 true AR038287A1 (es) | 2005-01-12 |
Family
ID=8871257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030100058A AR038287A1 (es) | 2002-01-11 | 2003-01-10 | Composicion farmaceutica que comprende una glitazona y un acido 4-oxobutanoico y uso de la misma para el tratamiento de la diabetes |
Country Status (16)
Country | Link |
---|---|
US (1) | US20050085489A1 (es) |
EP (1) | EP1463503A1 (es) |
JP (1) | JP2005516963A (es) |
KR (1) | KR20040078109A (es) |
CN (1) | CN1599608A (es) |
AR (1) | AR038287A1 (es) |
AU (1) | AU2002361421A1 (es) |
BR (1) | BR0215498A (es) |
CA (1) | CA2473043A1 (es) |
FR (1) | FR2834640B1 (es) |
HU (1) | HUP0402645A2 (es) |
MX (1) | MXPA04006675A (es) |
PL (1) | PL370175A1 (es) |
RU (1) | RU2004124523A (es) |
WO (1) | WO2003057216A1 (es) |
ZA (1) | ZA200406329B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6346658B2 (ja) | 2013-03-14 | 2018-06-20 | ダート・ニューロサイエンス・(ケイマン)・リミテッド | Mao阻害剤としての置換ナフチリジン及びキノリン化合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5863915A (en) * | 1996-05-15 | 1999-01-26 | Bayer Corporation | Substituted 4-arylbutyric acid derivatives as matrix metalloprotease |
FR2752422B1 (fr) * | 1996-08-16 | 1998-11-06 | Lipha | Composition pharmaceutique contenant des acides 4-oxo-butanoiques |
US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
GB9922710D0 (en) * | 1999-09-24 | 1999-11-24 | Bayer Ag | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatatives for the treatment of multiple sclerosis |
-
2002
- 2002-01-11 FR FR0200335A patent/FR2834640B1/fr not_active Expired - Fee Related
- 2002-12-16 CN CNA028244060A patent/CN1599608A/zh active Pending
- 2002-12-16 EP EP02796640A patent/EP1463503A1/en not_active Withdrawn
- 2002-12-16 BR BR0215498-6A patent/BR0215498A/pt not_active IP Right Cessation
- 2002-12-16 US US10/501,069 patent/US20050085489A1/en not_active Abandoned
- 2002-12-16 JP JP2003557574A patent/JP2005516963A/ja active Pending
- 2002-12-16 HU HU0402645A patent/HUP0402645A2/hu unknown
- 2002-12-16 AU AU2002361421A patent/AU2002361421A1/en not_active Abandoned
- 2002-12-16 RU RU2004124523/15A patent/RU2004124523A/ru not_active Application Discontinuation
- 2002-12-16 WO PCT/EP2002/014311 patent/WO2003057216A1/en not_active Application Discontinuation
- 2002-12-16 KR KR10-2004-7008823A patent/KR20040078109A/ko not_active Application Discontinuation
- 2002-12-16 CA CA002473043A patent/CA2473043A1/en not_active Abandoned
- 2002-12-16 PL PL02370175A patent/PL370175A1/xx unknown
- 2002-12-16 MX MXPA04006675A patent/MXPA04006675A/es unknown
-
2003
- 2003-01-10 AR ARP030100058A patent/AR038287A1/es unknown
-
2004
- 2004-08-10 ZA ZA200406329A patent/ZA200406329B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20050085489A1 (en) | 2005-04-21 |
CA2473043A1 (en) | 2003-07-17 |
JP2005516963A (ja) | 2005-06-09 |
WO2003057216A1 (en) | 2003-07-17 |
KR20040078109A (ko) | 2004-09-08 |
HUP0402645A2 (hu) | 2005-07-28 |
MXPA04006675A (es) | 2004-10-04 |
CN1599608A (zh) | 2005-03-23 |
ZA200406329B (en) | 2005-09-20 |
BR0215498A (pt) | 2004-12-28 |
FR2834640B1 (fr) | 2004-09-24 |
FR2834640A1 (fr) | 2003-07-18 |
EP1463503A1 (en) | 2004-10-06 |
PL370175A1 (en) | 2005-05-16 |
RU2004124523A (ru) | 2005-06-10 |
AU2002361421A1 (en) | 2003-07-24 |
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