AR038233A1 - Derivados del drechsleranol, procedimiento para su preparacion y su utilizacion - Google Patents
Derivados del drechsleranol, procedimiento para su preparacion y su utilizacionInfo
- Publication number
- AR038233A1 AR038233A1 ARP030100225A ARP030100225A AR038233A1 AR 038233 A1 AR038233 A1 AR 038233A1 AR P030100225 A ARP030100225 A AR P030100225A AR P030100225 A ARP030100225 A AR P030100225A AR 038233 A1 AR038233 A1 AR 038233A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkenyl
- alkyl
- straight
- formula
- branched chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Producidos durante la fermentación por lo microorganismos Drechslera australiensis, ST 003360, DMS 14093 o, respectivamente, ST 004112, DMS 14524, a un procedimiento para su preparación, a la utilización de drechsleranoles como medicamentos, especialmente para el tratamiento y/o la profilaxis de neuropatías degenerativas, por ejemplo de la enfermedad de Alzheimer, o de enfermedades psíquicas tales como depresiones, trastorno del sueno o trastornos afectivos condicionados estacionalmente, y a la utilización de drechsleranoles como formadores de quelatos o como antioxidantes. Reivindicación 1: Compuesto de la fórmula (1), en al cual: R significa H o un grupo de la fórmula -(CH(OR2))5-CH2-OR2, y R1 y R2, independientemente entre sí, significan H, o un grupo alquilo (C1-6), alquenilo (C2-6), alquinilo (C2-6) o arilo (C5-10), en donde alquilo, alquenilo y alquinilo son de cadena lineal o ramificados, y en donde los grupos están sustituidos, eventualmente una o dos veces, con: (a) -OH, (b) =O, (c) -O-alquilo (C1-6), siendo alquilo de cadena lineal o ramificado, (d) -O-alquenilo (C2-6), siendo alquenilo de cadena lineal o ramificado, (e) -arilo, (f) -NH-alquilo (C1-6), siendo alquilo de cadena lineal o ramificado, (g) -NH-alquenilo (C2-6), siendo alquenilo de cadena lineal o ramificado, (h) -NH2, o (i) halógeno, en donde los sustituyentes (c) a (g) puede seguir estando sustituidos con funciones -CN, -amida u -oxima, o una forma estereoisómera del compuesto de la fórmula (1) o una sal fisiológicamente tolerable del compuesto de la fórmula (1) o una sal fisiológicamente tolerable de una forma estereoisómera de un compuesto de la fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10203557A DE10203557A1 (de) | 2002-01-29 | 2002-01-29 | Drechsleranol-Derivate, Verfahren zu deren Herstellung und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038233A1 true AR038233A1 (es) | 2005-01-05 |
Family
ID=7713383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100225A AR038233A1 (es) | 2002-01-29 | 2003-01-27 | Derivados del drechsleranol, procedimiento para su preparacion y su utilizacion |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1472240B1 (es) |
| JP (1) | JP4436134B2 (es) |
| AR (1) | AR038233A1 (es) |
| AT (1) | ATE466848T1 (es) |
| AU (1) | AU2003201963B2 (es) |
| BR (1) | BR0307199A (es) |
| CA (1) | CA2473988C (es) |
| DE (2) | DE10203557A1 (es) |
| IL (1) | IL163166A (es) |
| MX (1) | MXPA04006358A (es) |
| PE (1) | PE20030815A1 (es) |
| WO (1) | WO2003064405A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014208132A1 (ja) * | 2013-06-26 | 2014-12-31 | Dic株式会社 | フェノール性水酸基含有化合物、フェノール樹脂、硬化性組成物、その硬化物、半導体封止材料、及びプリント配線基板 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3068706B2 (ja) * | 1992-02-26 | 2000-07-24 | 塩野義製薬株式会社 | アルド−ス還元酵素阻害物質 |
-
2002
- 2002-01-29 DE DE10203557A patent/DE10203557A1/de not_active Withdrawn
-
2003
- 2003-01-20 CA CA2473988A patent/CA2473988C/en not_active Expired - Fee Related
- 2003-01-20 MX MXPA04006358A patent/MXPA04006358A/es active IP Right Grant
- 2003-01-20 AT AT03700811T patent/ATE466848T1/de not_active IP Right Cessation
- 2003-01-20 BR BR0307199-5A patent/BR0307199A/pt not_active Application Discontinuation
- 2003-01-20 AU AU2003201963A patent/AU2003201963B2/en not_active Ceased
- 2003-01-20 EP EP03700811A patent/EP1472240B1/de not_active Expired - Lifetime
- 2003-01-20 WO PCT/EP2003/000487 patent/WO2003064405A1/de active Application Filing
- 2003-01-20 DE DE50312692T patent/DE50312692D1/de not_active Expired - Lifetime
- 2003-01-20 JP JP2003564028A patent/JP4436134B2/ja not_active Expired - Fee Related
- 2003-01-27 AR ARP030100225A patent/AR038233A1/es not_active Application Discontinuation
- 2003-01-29 PE PE2003000091A patent/PE20030815A1/es not_active Application Discontinuation
-
2004
- 2004-07-22 IL IL163166A patent/IL163166A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4436134B2 (ja) | 2010-03-24 |
| AU2003201963B2 (en) | 2008-06-05 |
| IL163166A (en) | 2008-08-07 |
| ATE466848T1 (de) | 2010-05-15 |
| DE50312692D1 (de) | 2010-06-17 |
| EP1472240A1 (de) | 2004-11-03 |
| WO2003064405A1 (de) | 2003-08-07 |
| BR0307199A (pt) | 2004-11-03 |
| PE20030815A1 (es) | 2003-10-10 |
| JP2006503797A (ja) | 2006-02-02 |
| MXPA04006358A (es) | 2004-10-04 |
| CA2473988C (en) | 2011-05-03 |
| CA2473988A1 (en) | 2003-08-07 |
| EP1472240B1 (de) | 2010-05-05 |
| DE10203557A1 (de) | 2003-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201270505A1 (ru) | Производные иминотиадиазиндиоксида в качестве ингибиторов bace, композиции на их основе, и их применение | |
| EA201070597A1 (ru) | Антибактериальные аналоги аминогликозида | |
| PA8487601A1 (es) | Derivados biciclicos sustituidos utiles como agentes contra el cancer | |
| EA200702253A1 (ru) | Фармацевтическая композиция | |
| CY1119170T1 (el) | Ενωση γουανιδινης | |
| CY1113766T1 (el) | Παραγωγα ινδολιδονης για την θεραπεια ή προληψη ινωτικων ασθενειων | |
| EA200501098A1 (ru) | Антибактериальные агенты | |
| AR022076A1 (es) | Composicion antioxidante constituida por acetil l-carnitina y acido alfa-lipoico para mejorar el aprovechamiento metabolico de la glucosa | |
| CL2009000780A1 (es) | Compuestos derivados de heterociclil-pirano-heterociclilo, heterociclil-oxepina-heterociclilo, benzopirano-heterociclilo y benzoxepina-heterociclilo sustituidos; composicion farmaceutica; procedimiento de preparacion de la composicion; kit farmaceutico; y su uso en el tratamiento del cancer, mediado por la inhibicion de pi3k. | |
| EA201390626A1 (ru) | Производные гидроксамовой кислоты и применение указанных производных в лечении бактериальных инфекций | |
| CR8569A (es) | Inhibidores de integrasa de vih | |
| AR054347A1 (es) | Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion | |
| CY1108794T1 (el) | Σπειροκυκλικα παραγωγα κυκλοεξανιου | |
| RU2014115796A (ru) | Модуляторы ror-гамма | |
| UA110013C2 (uk) | Застосування композиції для лікування шарко-марі-тута і пов'язаних з нею розладів | |
| RU2015114797A (ru) | Композиции для ухода за полостью рта | |
| MX2008008556A (es) | Derivados de triterpenoquinonas y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias. | |
| AR077125A1 (es) | Combinaciones farmaceuticas utiles para tratar el vhc | |
| ES2084339T3 (es) | Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central. | |
| CA2904533C (en) | Enhanced osteogenic activity of daidzein analogs on human mesenchymal stem cells | |
| FI4061344T3 (fi) | 6-hydroksikannabidioli käytettäväksi lääkkeenä | |
| HRP20140896T1 (hr) | (-)-stereoizomer 2,6-di-sec-butilfenola i njegovi analozi za poticanje antiemetskog uäśinka, lijeäśenje muäśnine i povraä†anja, te lijeäśenje migrene | |
| AR075626A1 (es) | Metodos para administrar (4ar,10ar)-1-n- propil-1,2,3,4,4a,5,10,10a- octahidro -benzo (g) quinolin-6,7-diol y sus composiciones farmaceuticas. uso. | |
| EA201590074A1 (ru) | Производное бензодиоксола, способ его получения и его применение | |
| UA86873C2 (en) | SUBSTITUTED ARYL 1,4-PYRAZlNE DERIVATIVES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |