CY1119170T1 - Ενωση γουανιδινης - Google Patents

Ενωση γουανιδινης

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Publication number
CY1119170T1
CY1119170T1 CY20171100698T CY171100698T CY1119170T1 CY 1119170 T1 CY1119170 T1 CY 1119170T1 CY 20171100698 T CY20171100698 T CY 20171100698T CY 171100698 T CY171100698 T CY 171100698T CY 1119170 T1 CY1119170 T1 CY 1119170T1
Authority
CY
Cyprus
Prior art keywords
vap
pharmaceutical composition
prophylaxis
treatment
compound
Prior art date
Application number
CY20171100698T
Other languages
English (en)
Inventor
Kousei Yoshihara
Daisuke Suzuki
Susumu Yamaki
Hiroyoshi Yamada
Hisashi Mihara
Norio Seki
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of CY1119170T1 publication Critical patent/CY1119170T1/el

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Να παρασχεθεί ένωση η οποία να είναι χρήσιμη ως ενεργό συστατικό μείγματος φαρμακευτικής σύνθεσης, ιδιαίτερα δε φαρμακευτικής σύνθεσης για την προφύλαξη και/ή αγωγή των συσχετιζόμενων με VAP-1 παθήσεων. [Επίλυση] Ως αποτέλεσμα των εντατικών μελετών σε ένωση που έχει ανασταλτική δραστηριότητα του VAP-1, οι εφευρέτες έχουν επιτύχει την παρούσα εφεύρεση ανακαλύπτοντας ότι ένωση της παρούσας εφεύρεσης ή άλας εξ' αυτής έχει εξαιρετική ανασταλτική δραστηριότητα του VAP-1 και είναι τοιουτοτρόπως χρήσιμη για την προφύλαξη και/ή αγωγή των συσχετιζόμενων με VAP-1 παθήσεων, ιδιαίτερα δε για την προφύλαξη και/ή αγωγή της διαβητικής νεφροπάθειας ή του οιδήματος της διαβητικής ωχράς κηλίδας. Η παρούσα εφεύρεση σχετίζεται επίσης και με φαρμακευτική σύνθεση, ειδικότερα δε φαρμακευτική σύνθεση για την προφύλαξη και/ή αγωγή των συσχετιζόμενων με VAP-1 παθήσεων, η δε εν λόγω φαρμακευτική σύνθεση περιέχει ένωση της παρούσας εφεύρεσης ή άλας εξ'αυτής και έκδοχο.
CY20171100698T 2011-03-15 2017-06-30 Ενωση γουανιδινης CY1119170T1 (el)

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