AR036007A1 - Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en u - Google Patents
Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en uInfo
- Publication number
- AR036007A1 AR036007A1 ARP020100085A ARP020100085A AR036007A1 AR 036007 A1 AR036007 A1 AR 036007A1 AR P020100085 A ARP020100085 A AR P020100085A AR P020100085 A ARP020100085 A AR P020100085A AR 036007 A1 AR036007 A1 AR 036007A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- pharmaceutically acceptable
- amino
- acceptable salt
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 150000003839 salts Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title 1
- 229940125782 compound 2 Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- WTUIUCZGLGZOSG-UHFFFAOYSA-N 1-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid Chemical compound OC(=O)C1C2(N)C1CCC2C(O)=O WTUIUCZGLGZOSG-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010048962 Brain oedema Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000037212 Neonatal hypoxic and ischemic brain injury Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 208000006752 brain edema Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002461 excitatory amino acid Effects 0.000 abstract 1
- 239000003257 excitatory amino acid Substances 0.000 abstract 1
- 231100000040 eye damage Toxicity 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 201000010901 lateral sclerosis Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
- 208000033300 perinatal asphyxia Diseases 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 230000000391 smoking effect Effects 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01500007 | 2001-01-11 | ||
| EP01500206 | 2001-08-02 | ||
| US32978601P | 2001-10-16 | 2001-10-16 | |
| EP01500263A EP1310480A1 (en) | 2001-11-07 | 2001-11-07 | Prodrugs of excitatory amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036007A1 true AR036007A1 (es) | 2004-08-04 |
Family
ID=27440162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100085A AR036007A1 (es) | 2001-01-11 | 2002-01-11 | Compuesto del acido 2-[(2's)-(2'-amino)-propionil]amino-biciclo[3.1.0]hexano-2,6-dicarboxilico, sal farmaceuticamente aceptable del mismo, formulacion farmaceutica que lo comprende, proceso para preparar dicho compuesto, metodo para afectar los receptores de glutamato metabotropicos unidos-camp en u |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7256217B2 (https=) |
| EP (1) | EP1368304B1 (https=) |
| JP (1) | JP4064237B2 (https=) |
| KR (1) | KR20030090622A (https=) |
| CN (1) | CN1267407C (https=) |
| AR (1) | AR036007A1 (https=) |
| AT (1) | ATE356111T1 (https=) |
| AU (1) | AU2002228737B2 (https=) |
| BR (1) | BR0116770A (https=) |
| CA (1) | CA2433667C (https=) |
| CZ (1) | CZ303490B6 (https=) |
| DE (1) | DE60127182T2 (https=) |
| DZ (1) | DZ3461A1 (https=) |
| ES (1) | ES2282315T3 (https=) |
| HU (1) | HUP0400620A3 (https=) |
| IL (1) | IL156364A0 (https=) |
| MX (1) | MXPA03006186A (https=) |
| NO (1) | NO20033166L (https=) |
| NZ (1) | NZ526050A (https=) |
| PE (1) | PE20020829A1 (https=) |
| PL (1) | PL208413B1 (https=) |
| SK (1) | SK287934B6 (https=) |
| SV (1) | SV2003000836A (https=) |
| WO (1) | WO2002055481A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080058509A (ko) | 2002-06-11 | 2008-06-25 | 일라이 릴리 앤드 캄파니 | 흥분성 아미노산의 전구약물 |
| WO2010111080A2 (en) | 2009-03-27 | 2010-09-30 | Eli Lilly And Company | Optimized treatment of schizophrenia |
| AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
| DK2721012T3 (en) | 2011-06-17 | 2016-08-15 | Lilly Co Eli | Biclo (3.1.0) hexane-2,6-dicarboxylic acid derivatives as MGLU2 receptor agonist |
| AR089718A1 (es) | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
| CN112041310B (zh) * | 2018-04-17 | 2023-11-03 | 拜耳公司 | 制备包含具有酸-不稳定性的酮保护基的n-酰化氨基酸酯的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750566A (en) * | 1994-08-12 | 1998-05-12 | Eli Lilly And Company | Synthetic excitatory amino acids |
| PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| ATE206915T1 (de) | 1994-08-12 | 2001-11-15 | Lilly Co Eli | Behandlung von angstzuständen |
| IL118727A (en) | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| DE69906492T2 (de) | 1998-01-28 | 2003-12-18 | Taisho Pharmaceutical Co., Ltd. | Fluorhaltige aminosäurederivate |
| GB9815542D0 (en) | 1998-07-17 | 1998-09-16 | Lilly Co Eli | Bicyclohexane derivatives |
| US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| US7038077B2 (en) | 2001-01-11 | 2006-05-02 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| EP1423411A2 (en) | 2001-07-09 | 2004-06-02 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| EP1463713A1 (en) | 2001-11-23 | 2004-10-06 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| WO2003057661A1 (en) | 2001-12-21 | 2003-07-17 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
-
2001
- 2001-12-14 HU HU0400620A patent/HUP0400620A3/hu unknown
- 2001-12-14 CN CNB018219667A patent/CN1267407C/zh not_active Expired - Fee Related
- 2001-12-14 NZ NZ526050A patent/NZ526050A/en unknown
- 2001-12-14 US US10/250,448 patent/US7256217B2/en not_active Expired - Fee Related
- 2001-12-14 IL IL15636401A patent/IL156364A0/xx unknown
- 2001-12-21 BR BR0116770-7A patent/BR0116770A/pt not_active IP Right Cessation
- 2001-12-21 SK SK826-2003A patent/SK287934B6/sk not_active IP Right Cessation
- 2001-12-21 AT AT01989859T patent/ATE356111T1/de not_active IP Right Cessation
- 2001-12-21 CA CA2433667A patent/CA2433667C/en not_active Expired - Fee Related
- 2001-12-21 KR KR10-2003-7009216A patent/KR20030090622A/ko not_active Withdrawn
- 2001-12-21 EP EP01989859A patent/EP1368304B1/en not_active Expired - Lifetime
- 2001-12-21 PL PL361669A patent/PL208413B1/pl unknown
- 2001-12-21 DZ DZ013461A patent/DZ3461A1/fr active
- 2001-12-21 DE DE60127182T patent/DE60127182T2/de not_active Expired - Lifetime
- 2001-12-21 JP JP2002556156A patent/JP4064237B2/ja not_active Expired - Fee Related
- 2001-12-21 AU AU2002228737A patent/AU2002228737B2/en not_active Ceased
- 2001-12-21 WO PCT/US2001/045866 patent/WO2002055481A1/en not_active Ceased
- 2001-12-21 ES ES01989859T patent/ES2282315T3/es not_active Expired - Lifetime
- 2001-12-21 CZ CZ20031916A patent/CZ303490B6/cs not_active IP Right Cessation
- 2001-12-21 MX MXPA03006186A patent/MXPA03006186A/es active IP Right Grant
-
2002
- 2002-01-10 PE PE2002000010A patent/PE20020829A1/es not_active Application Discontinuation
- 2002-01-11 SV SV2002000836A patent/SV2003000836A/es not_active Application Discontinuation
- 2002-01-11 AR ARP020100085A patent/AR036007A1/es unknown
-
2003
- 2003-07-10 NO NO20033166A patent/NO20033166L/no not_active Application Discontinuation
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