AR035551A1 - Polimorfos de la sal difosfato de un derivado de 4''-sustituido-9-desoxo-9a-aza-9a-homoeritromicina, su composicion farmaceutica, procedimiento de preparacion y uso en medicina - Google Patents
Polimorfos de la sal difosfato de un derivado de 4''-sustituido-9-desoxo-9a-aza-9a-homoeritromicina, su composicion farmaceutica, procedimiento de preparacion y uso en medicinaInfo
- Publication number
- AR035551A1 AR035551A1 ARP000103255A ARP000103255A AR035551A1 AR 035551 A1 AR035551 A1 AR 035551A1 AR P000103255 A ARP000103255 A AR P000103255A AR P000103255 A ARP000103255 A AR P000103255A AR 035551 A1 AR035551 A1 AR 035551A1
- Authority
- AR
- Argentina
- Prior art keywords
- mammals
- crystalline
- diphosphate
- diphosphate salt
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Dos polimorfos de una sal difosfato cristalina de (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[ [2,6-dideoxi-3-C-metil-3-O-metil-4-C- [propilamino)amino]metil]-alfa-L-ribo-hexopiranosil]-oxi]-2-etil-3,4,10-trihidroxi-3,5,8,10,12,14-hexametil-11-[[3,4,6-trideoxi-3-(dimetilamino)-beta-D-xilo-hexopiranosil]-oxi]-1-oxa-6-azaciclopentadecan-15-ona que es útil como agente antibacteriano y antiprotozoario en mamíferos. También se describen a composiciones farmacéuticas que contienen la base libre de la sal difosfato y su uso para la preparación de medicamentos para el tratamiento de infecciones bacterianas y protozoarias en mamíferos, mediante la administración de la base libre de la sal difosfato a mamíferos que requieren dicho tratamiento. La base libre de la sal difosfato de la presente posee una potente actividad contra diversas infecciones bacterianas y protozoarias cuando se administra por vía parenteral a mamíferos. Se describe también un procedimiento de preparación del compuesto, según fórmula (1) donde n es un número de 0 a 8 y los polimorfos se seleccionan entre el grupo compuesto por: a) una mesofase cristalina esméctica de un cristal líquido; y b) un disfosfato cristalino que presente el modelo de difracción de rayos X de polvo. N° pico 1 2 3 4 5 6 7 8 9 10 Espacio d 16,2 12,4 10,8 9,0 6,9 6,5 6,2 5,4 5,1 4,9
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14168199P | 1999-06-30 | 1999-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035551A1 true AR035551A1 (es) | 2004-06-16 |
Family
ID=22496734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103255A AR035551A1 (es) | 1999-06-30 | 2000-06-28 | Polimorfos de la sal difosfato de un derivado de 4''-sustituido-9-desoxo-9a-aza-9a-homoeritromicina, su composicion farmaceutica, procedimiento de preparacion y uso en medicina |
Country Status (42)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465437B1 (en) * | 1999-06-30 | 2002-10-15 | Pfizer Inc. | Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition |
| US6791660B1 (en) * | 2002-02-12 | 2004-09-14 | Seiko Epson Corporation | Method for manufacturing electrooptical device and apparatus for manufacturing the same, electrooptical device and electronic appliances |
| US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
| WO2013013834A1 (en) | 2011-07-27 | 2013-01-31 | Farma Grs, D.O.O. | New crystalline forms of tulathromycin |
| CN106008622A (zh) * | 2016-08-02 | 2016-10-12 | 海门慧聚药业有限公司 | 泰拉霉素新晶型及其制备 |
| CN110885351A (zh) * | 2019-12-17 | 2020-03-17 | 海门慧聚药业有限公司 | 泰拉霉素磷酸盐的晶型及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| SI9011409A (en) * | 1990-07-18 | 1995-10-31 | Pliva Pharm & Chem Works | O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them |
| HN1998000086A (es) * | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
| JP2003512290A (ja) * | 1997-09-10 | 2003-04-02 | メルク エンド カムパニー インコーポレーテッド | 家畜抗菌剤としての８ａ−アザライド |
| UA70972C2 (uk) * | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
| OA11876A (en) * | 1999-05-18 | 2006-03-27 | Pfizer Prod Inc | Novel crystalline forms of a macrolide antibiotic. |
| US6465437B1 (en) * | 1999-06-30 | 2002-10-15 | Pfizer Inc. | Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition |
-
2000
- 2000-05-18 US US09/574,160 patent/US6465437B1/en not_active Expired - Fee Related
- 2000-06-01 HN HN2000000090A patent/HN2000000090A/es unknown
- 2000-06-06 PA PA20008496901A patent/PA8496901A1/es unknown
- 2000-06-13 AT AT00931491T patent/ATE286906T1/de not_active IP Right Cessation
- 2000-06-13 CN CNA200710199182XA patent/CN101220067A/zh active Pending
- 2000-06-13 KR KR10-2001-7016939A patent/KR100442508B1/ko not_active IP Right Cessation
- 2000-06-13 WO PCT/IB2000/000785 patent/WO2001002414A1/en active IP Right Grant
- 2000-06-13 TR TR2001/03834T patent/TR200103834T2/xx unknown
- 2000-06-13 AU AU49439/00A patent/AU772277B2/en not_active Ceased
- 2000-06-13 YU YU88701A patent/YU88701A/sh unknown
- 2000-06-13 EA EA200101178A patent/EA004235B1/ru not_active IP Right Cessation
- 2000-06-13 SK SK1892-2001A patent/SK286243B6/sk not_active IP Right Cessation
- 2000-06-13 DE DE60017399T patent/DE60017399T2/de not_active Expired - Fee Related
- 2000-06-13 IL IL14640888A patent/IL146408A0/xx unknown
- 2000-06-13 PT PT00931491T patent/PT1189913E/pt unknown
- 2000-06-13 BR BR0012091-0A patent/BR0012091A/pt not_active IP Right Cessation
- 2000-06-13 AP APAP/P/2001/002370A patent/AP2001002370A0/en unknown
- 2000-06-13 UA UA2001129148A patent/UA71013C2/uk unknown
- 2000-06-13 CA CA002376748A patent/CA2376748C/en not_active Expired - Fee Related
- 2000-06-13 PL PL352900A patent/PL201891B1/pl unknown
- 2000-06-13 HU HU0201693A patent/HUP0201693A3/hu unknown
- 2000-06-13 ES ES00931491T patent/ES2233380T3/es not_active Expired - Lifetime
- 2000-06-13 OA OA1200100329A patent/OA11965A/en unknown
- 2000-06-13 JP JP2001507850A patent/JP2003503506A/ja active Pending
- 2000-06-13 MX MXPA02000058A patent/MXPA02000058A/es active IP Right Grant
- 2000-06-13 CZ CZ20014571A patent/CZ20014571A3/cs unknown
- 2000-06-13 CN CN00809635A patent/CN1358188A/zh active Pending
- 2000-06-13 EP EP00931491A patent/EP1189913B1/en not_active Expired - Lifetime
- 2000-06-13 EE EEP200100699A patent/EE05068B1/xx not_active IP Right Cessation
- 2000-06-16 CO CO00045176A patent/CO5190679A1/es not_active Application Discontinuation
- 2000-06-26 UY UY26221A patent/UY26221A1/es not_active Application Discontinuation
- 2000-06-27 PE PE2000000645A patent/PE20010287A1/es not_active Application Discontinuation
- 2000-06-28 GT GT200000105A patent/GT200000105A/es unknown
- 2000-06-28 MY MYPI20002923 patent/MY133360A/en unknown
- 2000-06-28 MA MA26011A patent/MA26745A1/fr unknown
- 2000-06-28 GT GT200000105AK patent/GT200000105AA/es unknown
- 2000-06-28 AR ARP000103255A patent/AR035551A1/es not_active Application Discontinuation
- 2000-06-28 TN TNTNSN00143A patent/TNSN00143A1/fr unknown
- 2000-06-30 EC EC2000003555A patent/ECSP003555A/es unknown
-
2001
- 2001-11-13 IS IS6159A patent/IS6159A/is unknown
- 2001-11-20 BG BG106123A patent/BG65587B1/bg unknown
- 2001-12-11 HR HR20010919A patent/HRP20010919B1/xx not_active IP Right Cessation
- 2001-12-19 NO NO20016221A patent/NO20016221L/no not_active Application Discontinuation
- 2001-12-20 ZA ZA200110453A patent/ZA200110453B/xx unknown
-
2002
- 2002-08-12 US US10/218,154 patent/US6861412B2/en not_active Expired - Fee Related
-
2004
- 2004-05-06 US US10/840,529 patent/US7297682B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal | ||
| FB | Suspension of granting procedure |