AR032066A1 - Agente para tratamiento terapeutico y profilactico del dolor neuropatico - Google Patents
Agente para tratamiento terapeutico y profilactico del dolor neuropaticoInfo
- Publication number
- AR032066A1 AR032066A1 ARP010106055A ARP010106055A AR032066A1 AR 032066 A1 AR032066 A1 AR 032066A1 AR P010106055 A ARP010106055 A AR P010106055A AR P010106055 A ARP010106055 A AR P010106055A AR 032066 A1 AR032066 A1 AR 032066A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- atoms
- therapeutic
- carbon atoms
- neuropathic pain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un medicamento para el tratamiento terapéutico y/o profiláctico del dolor neuropático que comprende un compuesto representado por la formula general (1) o una sal farmacéuticamente aceptable del mismo como un ingrediente activo, en donde R1 representa un átomo de hidrogeno o un grupo hidroxilo; R2 representa un átomo de hidrogeno o un grupo alquilo que posee 1 a 3 átomos de carbono; R3 representa un grupo fenilo el cual puede poseer 1 a 3 átomos o sustituyentes seleccionados del grupo que consiste de un átomo halogeno, un grupo hidroxilo, un grupo alquilo que posee 1 a 3 átomos de carbono, y un grupo alcoxilo que posee 1 a 3 átomos de carbono, o representa -NH-R4 en donde R4 representa un grupo fenilo que pueden poseer 1 a 3 átomos o sustituyentes seleccionados del grupo que consiste en un átomo de halogeno, un grupo hidroxilo, un grupo alquilo que posee 1 a 3 átomos de carbono, y un grupo alcoxilo que posee 1 a 3 átomos de carbono o átomo de hidrogeno, y n representa 0 o 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000400679 | 2000-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032066A1 true AR032066A1 (es) | 2003-10-22 |
Family
ID=18865226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010106055A AR032066A1 (es) | 2000-12-28 | 2001-12-27 | Agente para tratamiento terapeutico y profilactico del dolor neuropatico |
Country Status (11)
Country | Link |
---|---|
US (1) | US7608636B2 (es) |
EP (1) | EP1356812B1 (es) |
JP (1) | JPWO2002053153A1 (es) |
KR (1) | KR100823668B1 (es) |
CN (1) | CN1484527A (es) |
AR (1) | AR032066A1 (es) |
AT (1) | ATE431142T1 (es) |
CA (1) | CA2433039C (es) |
DE (1) | DE60138733D1 (es) |
MX (1) | MXPA03005889A (es) |
WO (1) | WO2002053153A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2004089410A1 (ja) * | 2003-04-03 | 2006-07-06 | 協和醗酵工業株式会社 | 神経因性疼痛の予防及び/または治療剤 |
US7283839B2 (en) | 2004-04-14 | 2007-10-16 | Curitel Communications, Inc. | Wireless communicating terminal for providing integrated messaging service and method thereof |
US20060241144A1 (en) * | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
ITMI20070770A1 (it) | 2007-04-16 | 2008-10-17 | Brane Discovery S R L | Impiego di dimiracetam nel trattamento del dolore cronico |
WO2010044878A1 (en) * | 2008-10-16 | 2010-04-22 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
ES2664727T3 (es) * | 2009-10-22 | 2018-04-23 | University College Dublin National University Of Ireland, Dublin | Terapia causal de enfermedades o estados asociados con desmielinización del SNC o del SNP |
PL389364A1 (pl) | 2009-10-23 | 2011-04-26 | Uniwersytet Jagielloński | Nowe zastosowanie pochodnych 2-pirolidonu |
LV14346B (lv) * | 2009-11-05 | 2011-07-20 | Grindeks, A/S | 2-(4-Fenil-5-metil-2-oksopirolidin-1-il)-acetamīda 4R,5S-enantiomērs ar nootropo aktivitāti |
JP6082250B2 (ja) * | 2010-02-09 | 2017-02-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 認知機能を改善するための方法および組成物 |
KR101351181B1 (ko) | 2010-05-11 | 2014-01-14 | 가천대학교 산학협력단 | 단핵식세포계 세포 내에서 age-알부민의 합성 저해 또는 분비 저해에 의한 세포사 유도 저해 방법 |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
PL244071B1 (pl) * | 2019-01-07 | 2023-11-27 | Univ Jagiellonski | Pochodne (2,5-dioksopirolidyn-1-ylo)(fenylo)-acetamidu i ich zastosowanie do leczenia chorób o podłożu neurologicznym |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
JPS4219093Y1 (es) | 1965-11-27 | 1967-11-04 | ||
IT1045043B (it) | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
US4118393A (en) * | 1977-06-23 | 1978-10-03 | American Cyanamid Company | Phenyl azabicyclohexanones |
CU21107A3 (es) | 1978-02-10 | 1988-02-01 | Hoffmann La Roche | Pyrrolidines derivatives |
IT1141287B (it) | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
DE2923975A1 (de) | 1979-06-13 | 1980-12-18 | Nattermann A & Cie | Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel |
CH657527A5 (de) * | 1980-02-13 | 1986-09-15 | Ciba Geigy Ag | Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist. |
US4431641A (en) * | 1980-10-17 | 1984-02-14 | Ciba-Geigy Corporation | Pharmaceutical compositions having antiepileptic and antineuralgic action |
GB8412357D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
JPS625404A (ja) | 1985-07-01 | 1987-01-12 | Shinko Electric Co Ltd | 信号レベル変換装置 |
GB8609033D0 (en) * | 1986-04-14 | 1986-05-21 | Ucb Sa | Pharmaceutical compositions |
IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
JPH0779442B2 (ja) | 1989-07-14 | 1995-08-23 | 日本テレビ放送網株式会社 | 雑音減少回路 |
JPH04160496A (ja) | 1990-10-23 | 1992-06-03 | Sharp Corp | 自動販売機の物品搬出機構 |
US5232700A (en) * | 1990-11-14 | 1993-08-03 | The Administrators Of The Tulane Educational Fund | Methods of prophylaxis and treatment of herpes simplex lesions utilizing piracetam as the active ingredient |
JPH04219093A (ja) | 1990-12-19 | 1992-08-10 | Matsushita Electric Ind Co Ltd | 磁気記録再生装置 |
ZA923134B (en) | 1991-05-02 | 1993-01-27 | Daiichi Seiyaku Co | Agent for improving dementia |
JP3388778B2 (ja) | 1991-05-02 | 2003-03-24 | 第一製薬株式会社 | 脳血管性痴呆改善剤 |
CA2067614C (en) | 1991-05-02 | 2002-07-30 | Eiichi Otomo | Agent for improving dementia |
FI102748B (fi) | 1992-06-19 | 1999-02-15 | Daiichi Seiyaku Co | Menetelmä N-(2,6-dialkyylifenyyli)-2-(2-okso-1-pyrrolidinyyli)asetamid ijohdannaisen valmistamiseksi |
GB9505692D0 (en) * | 1995-03-21 | 1995-05-10 | Glaxo Group Ltd | Chemical compounds |
US5885976A (en) * | 1995-05-08 | 1999-03-23 | Sandyk; Reuven | Methods useful for the treatment of neurological and mental disorders related to deficient serotonin neurotransmission and impaired pineal melatonin functions |
WO1997006319A1 (en) * | 1995-08-04 | 1997-02-20 | Frederick Kobes | Piston valve |
US6107330A (en) | 1995-08-07 | 2000-08-22 | Daiichi Pharmaceutical Co., Ltd. | Inhibitor for narcotic analgesic dependence/resistance acquisition |
US5551846A (en) | 1995-12-01 | 1996-09-03 | Ford Motor Company | Scroll compressor capacity control valve |
CA2267375A1 (en) | 1996-10-01 | 1998-04-09 | Mitsunobu Yoshii | Mitochondrial membrane stabilizer |
DE69823851D1 (de) | 1997-07-15 | 2004-06-17 | Daiichi Seiyaku Co | Nefiracetam zur prophylaxe und behandlung von propofol verursachtem gedächtnisschwund |
AR020115A1 (es) | 1998-08-06 | 2002-04-10 | Daiichi Seiyaku Co | Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos |
CN1368882A (zh) | 1999-05-31 | 2002-09-11 | 第一制药株式会社 | 神经元死亡抑制剂 |
US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
US6349442B1 (en) * | 1999-06-23 | 2002-02-26 | Advanced Prosthetic Technologies, Inc. | Brush tip for a motorized toothbrush |
DE60034815T2 (de) | 1999-12-01 | 2008-01-31 | Ucb S.A. | Ein pyrrolidinacetatderivat zur behandlung von chronischem oder neuropathischem schmerz |
US6423739B1 (en) * | 2000-02-23 | 2002-07-23 | Daiichi Pharmaceutical Co., Ltd. | Method for aiding cerebral recovery following neurodegeneration |
-
2001
- 2001-12-25 US US10/450,524 patent/US7608636B2/en not_active Expired - Fee Related
- 2001-12-25 MX MXPA03005889A patent/MXPA03005889A/es not_active Application Discontinuation
- 2001-12-25 WO PCT/JP2001/011356 patent/WO2002053153A1/ja active Application Filing
- 2001-12-25 CA CA2433039A patent/CA2433039C/en not_active Expired - Fee Related
- 2001-12-25 AT AT01272527T patent/ATE431142T1/de not_active IP Right Cessation
- 2001-12-25 JP JP2002554103A patent/JPWO2002053153A1/ja active Pending
- 2001-12-25 DE DE60138733T patent/DE60138733D1/de not_active Expired - Lifetime
- 2001-12-25 KR KR1020037008668A patent/KR100823668B1/ko not_active IP Right Cessation
- 2001-12-25 CN CNA018216242A patent/CN1484527A/zh active Pending
- 2001-12-25 EP EP01272527A patent/EP1356812B1/en not_active Expired - Lifetime
- 2001-12-27 AR ARP010106055A patent/AR032066A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN1484527A (zh) | 2004-03-24 |
US7608636B2 (en) | 2009-10-27 |
EP1356812A1 (en) | 2003-10-29 |
KR100823668B1 (ko) | 2008-04-21 |
ATE431142T1 (de) | 2009-05-15 |
CA2433039C (en) | 2010-06-08 |
JPWO2002053153A1 (ja) | 2004-04-30 |
EP1356812B1 (en) | 2009-05-13 |
KR20040025882A (ko) | 2004-03-26 |
CA2433039A1 (en) | 2002-07-11 |
WO2002053153A1 (fr) | 2002-07-11 |
US20040063776A1 (en) | 2004-04-01 |
DE60138733D1 (de) | 2009-06-25 |
MXPA03005889A (es) | 2005-02-14 |
EP1356812A4 (en) | 2006-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |