AR023934A1 - Compuesto que consta de un derivado de benzodiacepina que se liga con un receptor iib/iiia de glicoproteina, composicion farmaceutica, agentecentellografico para la formacion de imagenes, complejo de un radionuclido emisor de y, quelado 99m tc de un compuesto que comprende una benzodiacepina, metodo - Google Patents

Compuesto que consta de un derivado de benzodiacepina que se liga con un receptor iib/iiia de glicoproteina, composicion farmaceutica, agentecentellografico para la formacion de imagenes, complejo de un radionuclido emisor de y, quelado 99m tc de un compuesto que comprende una benzodiacepina, metodo

Info

Publication number
AR023934A1
AR023934A1 ARP000101769A ARP000101769A AR023934A1 AR 023934 A1 AR023934 A1 AR 023934A1 AR P000101769 A ARP000101769 A AR P000101769A AR P000101769 A ARP000101769 A AR P000101769A AR 023934 A1 AR023934 A1 AR 023934A1
Authority
AR
Argentina
Prior art keywords
compound
iib
gli
linked
thrombus
Prior art date
Application number
ARP000101769A
Other languages
English (en)
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Publication of AR023934A1 publication Critical patent/AR023934A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K51/047—Benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos que constan de derivados de benodiacepina que se unen con receptores IIb-IIB de glicoproteína, los mencionados derivados enlazados en formacovalente a queladores de iones metálicos. Accesoriamente, composicion farmacéutica, agentecentello gráfico para la formacion de imágenes, complejo de unradionuclido emisor de g. quelado 99mTc de un compuesto que comprende una benzodiacepina, método para descubrir un trombo en el cuerpo de un mamífero y juegoque comprende una ampollasellada. Los c ompuestos se pueden marcar con un radionuclido tal como 99mTc y utilizarse para generar imágenes de trombos. Elcompuesto consta de un derivado de benzodiacepina que se liga con un receptor IIb/IIIa de glicoproteína, el cual está unidoen forma covale nte a un quelador deiones metálicos, en el que el compuesto retiene una considerable potencia para la inhibicion de la agregacion plaquetaria humana, tal como se mide en un ensayonormal de inhibicion de agregacion de plaquetas.Diagnostica de trombos por generacion de imágenes. Grupo de formula (1) en la que el R1 ligado a M es alquiloC1-8 inferior; los restantes Ri/i</=i</=6 son, cada uno y de manera independiente, H, alquilo inferior C1-8, alquilo sustituido, arilo,arilo sustituido o unacombi nacion de éstos: L1 es una fraccion ligante; Q es una fraccion con carga positiva que contiene nitrogeno y M es un quelador de iones metálicos. En laformula (2) M es un quelador de iones metálicos tal como Gli-Gli-Gli-Cisamida (SEC ID NO:1).
ARP000101769A 1999-04-14 2000-04-14 Compuesto que consta de un derivado de benzodiacepina que se liga con un receptor iib/iiia de glicoproteina, composicion farmaceutica, agentecentellografico para la formacion de imagenes, complejo de un radionuclido emisor de y, quelado 99m tc de un compuesto que comprende una benzodiacepina, metodo AR023934A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/292,067 US6171578B1 (en) 1999-04-14 1999-04-14 Benzodiazepine derivatives for imaging thrombi

Publications (1)

Publication Number Publication Date
AR023934A1 true AR023934A1 (es) 2002-09-04

Family

ID=23123049

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101769A AR023934A1 (es) 1999-04-14 2000-04-14 Compuesto que consta de un derivado de benzodiacepina que se liga con un receptor iib/iiia de glicoproteina, composicion farmaceutica, agentecentellografico para la formacion de imagenes, complejo de un radionuclido emisor de y, quelado 99m tc de un compuesto que comprende una benzodiacepina, metodo

Country Status (7)

Country Link
US (1) US6171578B1 (es)
EP (1) EP1171166A1 (es)
JP (1) JP2003503310A (es)
AR (1) AR023934A1 (es)
AU (1) AU4243100A (es)
CA (1) CA2372171A1 (es)
WO (1) WO2000061195A1 (es)

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US20030176663A1 (en) * 1998-05-11 2003-09-18 Eidgenossische Technische Hochscule Specific binding molecules for scintigraphy
US20080038274A1 (en) 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
AU4243201A (en) * 2000-02-24 2001-09-03 Eidgenoess Tech Hochschule Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis
EP1178317B1 (en) 2000-07-24 2004-11-10 Health Research, Inc. Method for detection of prostate specific membrane antigen in serum
PL364358A1 (en) * 2000-09-07 2004-12-13 Schering Ag Receptor in the edb fibronectin domain (ii)
ES2282326T3 (es) * 2000-10-24 2007-10-16 Cis Bio International Estabilizacion de composiciones radio-farmaceuticas usando tioeteres hidrofilicos o 6-hidroxicromanos hidrofilicos.
US6902718B2 (en) * 2000-10-24 2005-06-07 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
US6881396B2 (en) * 2000-10-24 2005-04-19 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy-chromans
US6989138B2 (en) 2000-10-24 2006-01-24 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
CA2468081A1 (en) * 2002-01-03 2003-07-10 Schering Aktiengesellschaft Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours
KR101194176B1 (ko) * 2003-12-22 2012-10-24 아지노모토 가부시키가이샤 신규한 페닐알라닌 유도체
JP4910695B2 (ja) * 2004-02-25 2012-04-04 アステラス製薬株式会社 血栓造影剤
EP1940841B9 (fr) 2005-10-07 2017-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
US8253725B2 (en) * 2007-12-28 2012-08-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and system for generating surface models of geometric structures
WO2010066051A1 (en) * 2008-12-12 2010-06-17 The Royal Institution For The Advancement Of Learning/Mcgill University Thiol-nota derivatives for kit 68ga radiolabeling
US10877021B2 (en) * 2016-04-21 2020-12-29 Osaka University Device for biological material detection, detection apparatus for biological material detection, method for measuring ion current, and method for identifying biological material

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US4656026A (en) 1984-12-10 1987-04-07 University Of Iowa Research Foundation Magnetic resonance (MR) image enhancement compounds for specific areas of the brain
US4997771A (en) 1987-04-27 1991-03-05 Schering Corporation Method for measuring the BZ-1 receptor binding activity in a test sample or test compound
US4777169A (en) 1987-07-24 1988-10-11 Hoffmann-La Roche Inc. Benzodiazepine derivatives
JPH0780858B2 (ja) 1987-10-19 1995-08-30 住友化学工業株式会社 放射性ベンゾジアゼピン誘導体およびその製造法
US5096695A (en) 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5830856A (en) 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5565449A (en) 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
JPH05310711A (ja) 1992-05-12 1993-11-22 Dainippon Pharmaceut Co Ltd スピンラベル化合物
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DE4337600A1 (de) 1993-11-01 1995-05-04 Diagnostikforschung Inst N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen
AU2371400A (en) * 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals

Also Published As

Publication number Publication date
EP1171166A1 (en) 2002-01-16
CA2372171A1 (en) 2000-10-19
US6171578B1 (en) 2001-01-09
AU4243100A (en) 2000-11-14
JP2003503310A (ja) 2003-01-28
WO2000061195A1 (en) 2000-10-19

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