AR021485A1 - Genes reguladores de streptomyces avermitilis para produccion aumentada de avermectinas. - Google Patents
Genes reguladores de streptomyces avermitilis para produccion aumentada de avermectinas.Info
- Publication number
- AR021485A1 AR021485A1 ARP990104584A ARP990104584A AR021485A1 AR 021485 A1 AR021485 A1 AR 021485A1 AR P990104584 A ARP990104584 A AR P990104584A AR P990104584 A ARP990104584 A AR P990104584A AR 021485 A1 AR021485 A1 AR 021485A1
- Authority
- AR
- Argentina
- Prior art keywords
- avermectins
- genes
- avermectines
- streptomyces avermitilis
- increased production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10013498P | 1998-09-14 | 1998-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021485A1 true AR021485A1 (es) | 2002-07-24 |
Family
ID=22278261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990104584A AR021485A1 (es) | 1998-09-14 | 1999-09-13 | Genes reguladores de streptomyces avermitilis para produccion aumentada de avermectinas. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6197591B1 (OSRAM) |
| EP (1) | EP0997528A1 (OSRAM) |
| JP (1) | JP3595210B2 (OSRAM) |
| KR (1) | KR100343357B1 (OSRAM) |
| CN (1) | CN1252440A (OSRAM) |
| AR (1) | AR021485A1 (OSRAM) |
| AU (1) | AU758329B2 (OSRAM) |
| BR (1) | BR9904109A (OSRAM) |
| CA (1) | CA2281935A1 (OSRAM) |
| HU (1) | HUP9903073A3 (OSRAM) |
| ID (1) | ID23542A (OSRAM) |
| IL (1) | IL131845A0 (OSRAM) |
| IN (1) | IN190976B (OSRAM) |
| PL (1) | PL335438A1 (OSRAM) |
| RU (1) | RU2221042C2 (OSRAM) |
| TR (1) | TR199902239A2 (OSRAM) |
| ZA (1) | ZA995872B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6720415B2 (en) * | 1998-12-02 | 2004-04-13 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
| US7326542B2 (en) * | 1998-12-02 | 2008-02-05 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
| DE60127948T2 (de) * | 2000-02-24 | 2008-01-17 | Kyowa Hakko Kogyo Co., Ltd. | Verfahren zur herstellung von avermectinderivaten |
| US6559176B1 (en) | 2000-05-10 | 2003-05-06 | Princeton University | Compounds and methods for regulating bacterial growth and pathogenesis |
| US7630836B2 (en) * | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| KR100718378B1 (ko) | 2002-02-12 | 2007-05-14 | 화이자 프로덕츠 인코포레이티드 | Ｂ2:ｂ1 아베르멕틴의 비를 제어하는 스트렙토마이세스아베르미틸리스 유전자 |
| US7326782B2 (en) * | 2003-08-21 | 2008-02-05 | Wisconsin Alumni Research Foundation | Metabolic engineering of viomycin biosynthesis |
| US7645600B2 (en) * | 2004-07-23 | 2010-01-12 | Shin-Etsu Chemical Co., Ltd. | Compositions and methods for enhanced bacterial exopolysaccharide production |
| KR100564156B1 (ko) * | 2004-08-23 | 2006-03-24 | 주식회사 진켐 | 스트렙토마이세스 푸세티우스 유래 전사활성체 및 그 유전자 |
| JP2006296419A (ja) * | 2005-03-04 | 2006-11-02 | Hiroshima Univ | 遺伝子破壊による抗生物質産生微生物の生産方法およびこれを用いて得られる抗生物質産生微生物、並びに抗生物質代謝中間体の生産方法 |
| CA2681581A1 (en) * | 2007-03-30 | 2008-10-09 | Abbott Laboratories | Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4362816A (en) | 1980-11-13 | 1982-12-07 | The Upjohn Company | Hybrid plasmid and process of making same |
| US4898828A (en) | 1985-08-07 | 1990-02-06 | Eli Lilly And Company | Ultrahigh copy number streptomycetes plasmids |
| US5242809A (en) | 1986-02-28 | 1993-09-07 | Smithkline Beecham Corporation | Gal operon of streptomyces |
| US5525506A (en) | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
| US5234831A (en) | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
| US5238848A (en) | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
| US5240850A (en) | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
| ATE89604T1 (de) | 1987-10-23 | 1993-06-15 | Pfizer | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. |
| DE3825615A1 (de) * | 1988-07-28 | 1990-02-01 | Behringwerke Ag | Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung |
| US5264354A (en) | 1988-09-30 | 1993-11-23 | Eli Lilly And Company | Method for isolating transposable elements from streptomyces |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| NZ233116A (en) | 1989-03-31 | 1994-09-27 | Merck & Co Inc | Cloning genes from steptomyces avermitilis for avermectin biosynthesis |
| US5122595A (en) | 1989-05-19 | 1992-06-16 | Applied Research Systems Ars Holding N.V. | SAF polypeptide gene coding therefor, and SAF promoter |
| US5118617A (en) | 1989-05-19 | 1992-06-02 | Applied Research Systems Ars Holding N.V. | Saf polypeptide, gene coding therefor, saf promoter and expression methods for expressing foreign dna sequences in streptomyces |
| US5292647A (en) * | 1992-11-30 | 1994-03-08 | Eli Lilly And Company | Strain of streptomyces for producing avermectins and processes therewith |
| AU6657294A (en) | 1993-07-30 | 1995-02-28 | Pfizer Inc. | Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis |
| FI942725L (fi) | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| US5474912A (en) | 1994-03-03 | 1995-12-12 | Sherman; David H. | Method for increasing production of microbial metabolites by genetic engineering |
| US5876987A (en) | 1996-02-07 | 1999-03-02 | Board Of Trustees Operating Michigan State University | Method, DNA and bacteria for hyperproduction of an antibiotic due to disruption of an AbsA gene |
-
1999
- 1999-09-07 US US09/390,721 patent/US6197591B1/en not_active Expired - Fee Related
- 1999-09-08 IN IN1203DE1999 patent/IN190976B/en unknown
- 1999-09-09 IL IL13184599A patent/IL131845A0/xx unknown
- 1999-09-13 ZA ZA9905872A patent/ZA995872B/xx unknown
- 1999-09-13 RU RU99119890/13A patent/RU2221042C2/ru not_active IP Right Cessation
- 1999-09-13 ID IDP990859A patent/ID23542A/id unknown
- 1999-09-13 AR ARP990104584A patent/AR021485A1/es not_active Application Discontinuation
- 1999-09-13 KR KR1019990039097A patent/KR100343357B1/ko not_active Expired - Fee Related
- 1999-09-13 EP EP99307230A patent/EP0997528A1/en not_active Ceased
- 1999-09-13 HU HU9903073A patent/HUP9903073A3/hu unknown
- 1999-09-14 TR TR1999/02239A patent/TR199902239A2/xx unknown
- 1999-09-14 CN CN99123897A patent/CN1252440A/zh active Pending
- 1999-09-14 CA CA002281935A patent/CA2281935A1/en not_active Abandoned
- 1999-09-14 JP JP26084299A patent/JP3595210B2/ja not_active Expired - Fee Related
- 1999-09-14 PL PL99335438A patent/PL335438A1/xx not_active Application Discontinuation
- 1999-09-14 BR BR9904109-0A patent/BR9904109A/pt not_active Application Discontinuation
- 1999-09-14 AU AU47575/99A patent/AU758329B2/en not_active Ceased
-
2000
- 2000-11-16 US US09/713,893 patent/US6689611B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2281935A1 (en) | 2000-03-14 |
| EP0997528A1 (en) | 2000-05-03 |
| IN190976B (OSRAM) | 2003-09-06 |
| KR20000023111A (ko) | 2000-04-25 |
| ID23542A (id) | 2000-05-04 |
| CN1252440A (zh) | 2000-05-10 |
| TR199902239A2 (xx) | 2000-04-21 |
| US6689611B1 (en) | 2004-02-10 |
| KR100343357B1 (ko) | 2002-07-15 |
| AU4757599A (en) | 2000-03-23 |
| HUP9903073A2 (en) | 2000-07-28 |
| RU2221042C2 (ru) | 2004-01-10 |
| HUP9903073A3 (en) | 2005-05-30 |
| BR9904109A (pt) | 2000-10-17 |
| US6197591B1 (en) | 2001-03-06 |
| IL131845A0 (en) | 2001-03-19 |
| JP3595210B2 (ja) | 2004-12-02 |
| JP2000102394A (ja) | 2000-04-11 |
| PL335438A1 (en) | 2000-03-27 |
| ZA995872B (en) | 2001-03-13 |
| HU9903073D0 (en) | 1999-11-29 |
| AU758329B2 (en) | 2003-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |