AR017581A1 - Derivados de acido alfa-hidrocarboxilico heterociclicamente sustituido, su uso para la preparacion de una composicion farmaceutica, combinaciones dedichos derivados y una o mas sustancias activas, preparados farmaceuticos para la administracion peroral y parental y fragmento estructural comprendido - Google Patents
Derivados de acido alfa-hidrocarboxilico heterociclicamente sustituido, su uso para la preparacion de una composicion farmaceutica, combinaciones dedichos derivados y una o mas sustancias activas, preparados farmaceuticos para la administracion peroral y parental y fragmento estructural comprendidoInfo
- Publication number
- AR017581A1 AR017581A1 ARP980105651A ARP980105651A AR017581A1 AR 017581 A1 AR017581 A1 AR 017581A1 AR P980105651 A ARP980105651 A AR P980105651A AR P980105651 A ARP980105651 A AR P980105651A AR 017581 A1 AR017581 A1 AR 017581A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- sulfur
- phenyl
- oxygen
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Derivados del ácido alfa-hidrocarboxílico heterocíclicamente sustituido segun formula (I) en donde R1 significa tetrazol o un grupo de formula II en dondeR tiene el siguiente significado: a) un resto OR5, en donde R5 significa: hidrogeno, el cation de un metal alcalino, el cation de un metal alcalinotérreo o union amonio orgánico fisiologicamente tolerable; cicloalquilo C3-8 alquilo C1-8, CH2-fenilo, alquenilo C3-8, alquilinilo-C3-8 o fenilo eventualmentesustituidos. b) un compuesto heteroaromático de 5 miembros, ligado a través de un átomo de nitrogeno, elegido entre: pirrolilo, pirazolilo, imidazolilo ytriazolilo, que pueden llevar uno o dos átomos de halogeno, o uno a dos grupos alquilo C1-4, o uno o dos grupos alcoxi C1-4 de formula (III), en la cual kpuede tomar los valores 0, 1 y 2, p los valores 1, 2, 3 y 4 y R6 representa: alquilo C1-4, cicloalquilo C3-8, alquenilo C3-8, alquinilo C3-8 o feniloeventualmente sustituido d) un resto de formula (IV) en donde R7 significa: alquilo-C1-4, alquenilo C3-8, alquinilo-C3-8, cicloalquilo-C3-8, pudiendo estosrestos llevar un resto alcoxi C1-4, alquiltio C1-4 y/o un resto fenilo; hologenoalquilo C1-4 o fenilo,eventualmente sustituido. A significa NR8R9, azido, OR10, SR10, o alquilo C1-4; X significa oxígeno, azufre, CR11 o NR12; con la condicion de que si X = CR11entonces Y=oxígeno o azufre o NR14. Y significa oxígeno, azufre, CR13 o NR14; con la condicion de que si Y = oxígeno o azufre o NR14;eentonces X =CR11. R2 y R3 (que pueden ser iguales o diferentes) significan: fenilo o naftilo, eventualmente sustituidos; ofenilo o naftilo; que pueden estar unidos entre sí en posicion orto a través de una ligadura directa, un grupo metileno, etileno o etenileno, un átomo deoxígeno oazufre o un grupo SO2, NH o N(alquilo C1-4); cicloalquilo C5-6, eventualmente sustituido; R4 y R11 (que pueden ser iguales o diferentes) significan:hidrogeno, halogeno, alcoxi C1-4, halogenoalcoxi C1-4, alqueniloxi C3-6, alquiniloxi C3-6, alquiltio C1-4, alquilcarbonilo C1-4, alcoxicarbonilo C1-4,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19750529A DE19750529A1 (de) | 1997-11-14 | 1997-11-14 | Neue heterocyclisch substituierte alpha-Hydroxycarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017581A1 true AR017581A1 (es) | 2001-09-12 |
Family
ID=7848772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105651A AR017581A1 (es) | 1997-11-14 | 1998-11-09 | Derivados de acido alfa-hidrocarboxilico heterociclicamente sustituido, su uso para la preparacion de una composicion farmaceutica, combinaciones dedichos derivados y una o mas sustancias activas, preparados farmaceuticos para la administracion peroral y parental y fragmento estructural comprendido |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6358983B1 (es) |
| EP (1) | EP1037883A1 (es) |
| JP (1) | JP2001523671A (es) |
| KR (1) | KR20010032083A (es) |
| CN (1) | CN1278805A (es) |
| AR (1) | AR017581A1 (es) |
| AU (1) | AU752165B2 (es) |
| BG (1) | BG104400A (es) |
| BR (1) | BR9814157A (es) |
| CA (1) | CA2308746A1 (es) |
| CO (1) | CO4990973A1 (es) |
| DE (1) | DE19750529A1 (es) |
| HR (1) | HRP980591A2 (es) |
| HU (1) | HUP0004341A3 (es) |
| ID (1) | ID24819A (es) |
| IL (1) | IL135461A0 (es) |
| NO (1) | NO20002154L (es) |
| NZ (1) | NZ504289A (es) |
| PL (1) | PL340756A1 (es) |
| SK (1) | SK4932000A3 (es) |
| TR (1) | TR200001365T2 (es) |
| WO (1) | WO1999025701A1 (es) |
| ZA (1) | ZA9810425B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1750862T3 (pl) * | 2004-06-04 | 2011-06-30 | Teva Pharma | Kompozycja farmaceutyczna zawierająca irbesartan |
| MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
-
1997
- 1997-11-14 DE DE19750529A patent/DE19750529A1/de not_active Withdrawn
-
1998
- 1998-11-04 BR BR9814157-0A patent/BR9814157A/pt not_active IP Right Cessation
- 1998-11-04 SK SK493-2000A patent/SK4932000A3/sk unknown
- 1998-11-04 HU HU0004341A patent/HUP0004341A3/hu unknown
- 1998-11-04 ID IDW20000882A patent/ID24819A/id unknown
- 1998-11-04 WO PCT/EP1998/007026 patent/WO1999025701A1/de not_active Application Discontinuation
- 1998-11-04 IL IL13546198A patent/IL135461A0/xx unknown
- 1998-11-04 PL PL98340756A patent/PL340756A1/xx not_active Application Discontinuation
- 1998-11-04 AU AU14878/99A patent/AU752165B2/en not_active Ceased
- 1998-11-04 NZ NZ504289A patent/NZ504289A/en unknown
- 1998-11-04 CA CA002308746A patent/CA2308746A1/en not_active Abandoned
- 1998-11-04 JP JP2000521084A patent/JP2001523671A/ja active Pending
- 1998-11-04 KR KR1020007005207A patent/KR20010032083A/ko not_active Application Discontinuation
- 1998-11-04 CN CN98811085A patent/CN1278805A/zh active Pending
- 1998-11-04 EP EP98958900A patent/EP1037883A1/de not_active Withdrawn
- 1998-11-04 TR TR2000/01365T patent/TR200001365T2/xx unknown
- 1998-11-04 US US09/530,382 patent/US6358983B1/en not_active Expired - Fee Related
- 1998-11-09 AR ARP980105651A patent/AR017581A1/es not_active Application Discontinuation
- 1998-11-13 HR HR19750529.5A patent/HRP980591A2/hr not_active Application Discontinuation
- 1998-11-13 ZA ZA9810425A patent/ZA9810425B/xx unknown
- 1998-11-13 CO CO98067231A patent/CO4990973A1/es unknown
-
2000
- 2000-04-27 NO NO20002154A patent/NO20002154L/no not_active Application Discontinuation
- 2000-05-04 BG BG104400A patent/BG104400A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG104400A (en) | 2001-01-31 |
| WO1999025701A1 (de) | 1999-05-27 |
| JP2001523671A (ja) | 2001-11-27 |
| HUP0004341A3 (en) | 2001-12-28 |
| SK4932000A3 (en) | 2001-02-12 |
| NZ504289A (en) | 2002-03-01 |
| CA2308746A1 (en) | 1999-05-27 |
| AU752165B2 (en) | 2002-09-05 |
| AU1487899A (en) | 1999-06-07 |
| NO20002154L (no) | 2000-05-12 |
| KR20010032083A (ko) | 2001-04-16 |
| TR200001365T2 (tr) | 2000-09-21 |
| BR9814157A (pt) | 2000-10-03 |
| IL135461A0 (en) | 2001-05-20 |
| EP1037883A1 (de) | 2000-09-27 |
| US6358983B1 (en) | 2002-03-19 |
| PL340756A1 (en) | 2001-02-26 |
| ID24819A (id) | 2000-08-24 |
| HRP980591A2 (en) | 1999-08-31 |
| HUP0004341A1 (hu) | 2001-10-28 |
| NO20002154D0 (no) | 2000-04-27 |
| CN1278805A (zh) | 2001-01-03 |
| CO4990973A1 (es) | 2000-12-26 |
| ZA9810425B (en) | 2000-05-15 |
| DE19750529A1 (de) | 1999-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |