IL135461A0 - NOVEL HETEROCYCLICALLY SUBSTITUTED α- HYDROXYCARBOXLIC ACID DERIVATIVES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS - Google Patents
NOVEL HETEROCYCLICALLY SUBSTITUTED α- HYDROXYCARBOXLIC ACID DERIVATIVES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTSInfo
- Publication number
- IL135461A0 IL135461A0 IL13546198A IL13546198A IL135461A0 IL 135461 A0 IL135461 A0 IL 135461A0 IL 13546198 A IL13546198 A IL 13546198A IL 13546198 A IL13546198 A IL 13546198A IL 135461 A0 IL135461 A0 IL 135461A0
- Authority
- IL
- Israel
- Prior art keywords
- producing
- same
- acid derivatives
- receptor antagonists
- endothelin receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19750529A DE19750529A1 (de) | 1997-11-14 | 1997-11-14 | Neue heterocyclisch substituierte alpha-Hydroxycarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
PCT/EP1998/007026 WO1999025701A1 (de) | 1997-11-14 | 1998-11-04 | NEUE HETEROCYCLISCH SUBSTITUIERTE α-HYDROXYCARBONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ENDOTHELINREZEPTORANTAGONISTEN |
Publications (1)
Publication Number | Publication Date |
---|---|
IL135461A0 true IL135461A0 (en) | 2001-05-20 |
Family
ID=7848772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13546198A IL135461A0 (en) | 1997-11-14 | 1998-11-04 | NOVEL HETEROCYCLICALLY SUBSTITUTED α- HYDROXYCARBOXLIC ACID DERIVATIVES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS |
Country Status (23)
Country | Link |
---|---|
US (1) | US6358983B1 (xx) |
EP (1) | EP1037883A1 (xx) |
JP (1) | JP2001523671A (xx) |
KR (1) | KR20010032083A (xx) |
CN (1) | CN1278805A (xx) |
AR (1) | AR017581A1 (xx) |
AU (1) | AU752165B2 (xx) |
BG (1) | BG104400A (xx) |
BR (1) | BR9814157A (xx) |
CA (1) | CA2308746A1 (xx) |
CO (1) | CO4990973A1 (xx) |
DE (1) | DE19750529A1 (xx) |
HR (1) | HRP980591A2 (xx) |
HU (1) | HUP0004341A3 (xx) |
ID (1) | ID24819A (xx) |
IL (1) | IL135461A0 (xx) |
NO (1) | NO20002154L (xx) |
NZ (1) | NZ504289A (xx) |
PL (1) | PL340756A1 (xx) |
SK (1) | SK4932000A3 (xx) |
TR (1) | TR200001365T2 (xx) |
WO (1) | WO1999025701A1 (xx) |
ZA (1) | ZA9810425B (xx) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1750862T3 (pl) * | 2004-06-04 | 2011-06-30 | Teva Pharma | Kompozycja farmaceutyczna zawierająca irbesartan |
MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
-
1997
- 1997-11-14 DE DE19750529A patent/DE19750529A1/de not_active Withdrawn
-
1998
- 1998-11-04 BR BR9814157-0A patent/BR9814157A/pt not_active IP Right Cessation
- 1998-11-04 SK SK493-2000A patent/SK4932000A3/sk unknown
- 1998-11-04 HU HU0004341A patent/HUP0004341A3/hu unknown
- 1998-11-04 ID IDW20000882A patent/ID24819A/id unknown
- 1998-11-04 WO PCT/EP1998/007026 patent/WO1999025701A1/de not_active Application Discontinuation
- 1998-11-04 IL IL13546198A patent/IL135461A0/xx unknown
- 1998-11-04 PL PL98340756A patent/PL340756A1/xx not_active Application Discontinuation
- 1998-11-04 AU AU14878/99A patent/AU752165B2/en not_active Ceased
- 1998-11-04 NZ NZ504289A patent/NZ504289A/en unknown
- 1998-11-04 CA CA002308746A patent/CA2308746A1/en not_active Abandoned
- 1998-11-04 JP JP2000521084A patent/JP2001523671A/ja active Pending
- 1998-11-04 KR KR1020007005207A patent/KR20010032083A/ko not_active Application Discontinuation
- 1998-11-04 CN CN98811085A patent/CN1278805A/zh active Pending
- 1998-11-04 EP EP98958900A patent/EP1037883A1/de not_active Withdrawn
- 1998-11-04 TR TR2000/01365T patent/TR200001365T2/xx unknown
- 1998-11-04 US US09/530,382 patent/US6358983B1/en not_active Expired - Fee Related
- 1998-11-09 AR ARP980105651A patent/AR017581A1/es not_active Application Discontinuation
- 1998-11-13 HR HR19750529.5A patent/HRP980591A2/hr not_active Application Discontinuation
- 1998-11-13 ZA ZA9810425A patent/ZA9810425B/xx unknown
- 1998-11-13 CO CO98067231A patent/CO4990973A1/es unknown
-
2000
- 2000-04-27 NO NO20002154A patent/NO20002154L/no not_active Application Discontinuation
- 2000-05-04 BG BG104400A patent/BG104400A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BG104400A (en) | 2001-01-31 |
WO1999025701A1 (de) | 1999-05-27 |
JP2001523671A (ja) | 2001-11-27 |
AR017581A1 (es) | 2001-09-12 |
HUP0004341A3 (en) | 2001-12-28 |
SK4932000A3 (en) | 2001-02-12 |
NZ504289A (en) | 2002-03-01 |
CA2308746A1 (en) | 1999-05-27 |
AU752165B2 (en) | 2002-09-05 |
AU1487899A (en) | 1999-06-07 |
NO20002154L (no) | 2000-05-12 |
KR20010032083A (ko) | 2001-04-16 |
TR200001365T2 (tr) | 2000-09-21 |
BR9814157A (pt) | 2000-10-03 |
EP1037883A1 (de) | 2000-09-27 |
US6358983B1 (en) | 2002-03-19 |
PL340756A1 (en) | 2001-02-26 |
ID24819A (id) | 2000-08-24 |
HRP980591A2 (en) | 1999-08-31 |
HUP0004341A1 (hu) | 2001-10-28 |
NO20002154D0 (no) | 2000-04-27 |
CN1278805A (zh) | 2001-01-03 |
CO4990973A1 (es) | 2000-12-26 |
ZA9810425B (en) | 2000-05-15 |
DE19750529A1 (de) | 1999-05-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL123581A0 (en) | Pyrimidine derivatives as 5HT2c- receptor antagonists | |
AU5265599A (en) | Amine compounds, their production and their use as somatostatin receptor antagonists or agonists | |
AU2143295A (en) | Neurokinin receptor antagonists | |
AU5640299A (en) | 4-quinolinemethanol derivatives as purine receptor antagonists.(ii) | |
HUP0202202A3 (en) | Benzoxepino [2,3-b]pyridine derivatives and analogues as chemokine receptor antagonists and the use thereof | |
HK1030939A1 (en) | Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists | |
ZA200201788B (en) | Substituted 1,5-dihydropyrrol-2-on derivatives as NMDA receptor antagonists for the treatment of pain. | |
HRP20000002B1 (en) | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists | |
ZA989784B (en) | Novel cyclopentene derivatives useful as antagonists of the motilin receptor. | |
GR3033415T3 (en) | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | |
HK1045684A1 (en) | Biphenyl derivatives as antagonists of the neurokinine-1 receptor. | |
EP0986553A4 (en) | DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS | |
NZ315846A (en) | Endothelin receptor antagonists, in particular, substituted pyrazol-4-yl-substituted-prop-2-enoic acid derivatives | |
ZA979670B (en) | Piperazino derivatives as neurokinin antagonists. | |
AU3032397A (en) | Pyrrolyl quinoxalindiones, their production and use as ampa receptor antagonists | |
AU5659498A (en) | Heterocyclic carboxylic acid derivatives, their preparation ans use as endothelin receptor antagonists | |
IL133104A0 (en) | New - beta-amino and beta-azidocarboxylic acid derivatives the production thereof and the use thereof as endothelin receptor antagonists | |
AU2673201A (en) | Alpha-arylethylpiperazine derivatives as neurokinin antagonists | |
HUP9801938A3 (en) | Substituted phenyl compounds as endothelin antagonists, process for producing and use thereof | |
HUP0004341A3 (en) | Novel heterocyclically substituted alpha-hydroxycarboxilic acid derivatives, method for producing the same and their use as endothelin receptor antagonists | |
GB9705861D0 (en) | Trypthophan ureas as neurokinin antagonists | |
HK1042095A1 (zh) | 新型β-酰氨基-和β-氨磺酰羧酸衍生物,它們的製備和作為內皮縮血管肽受體拮抗物的應用 | |
IL137038A0 (en) | 5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists | |
ZA99171B (en) | Piperazino derivatives as neurokinin antagonists. | |
GR3033237T3 (en) | Quinoline derivatives as leukoriene antagonists. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HP | Change in proprietorship |