CO4900038A1 - Nuevos derivados de acidos carboxilicos, su obtencion y aplicacion - Google Patents
Nuevos derivados de acidos carboxilicos, su obtencion y aplicacionInfo
- Publication number
- CO4900038A1 CO4900038A1 CO97018895A CO97018895A CO4900038A1 CO 4900038 A1 CO4900038 A1 CO 4900038A1 CO 97018895 A CO97018895 A CO 97018895A CO 97018895 A CO97018895 A CO 97018895A CO 4900038 A1 CO4900038 A1 CO 4900038A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- phenyl
- alkoxy
- alkylthio
- halogen
- Prior art date
Links
- -1 CARBOXYL ACIDS Chemical class 0.000 title abstract 19
- 239000002253 acid Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 19
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 9
- 125000004414 alkyl thio group Chemical group 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 9
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- 125000001188 haloalkyl group Chemical group 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 6
- 125000003282 alkyl amino group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 4
- 239000011593 sulfur Substances 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 125000001624 naphthyl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 abstract 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- FONOSWYYBCBQGN-UHFFFAOYSA-N ethylene dione Chemical group O=C=C=O FONOSWYYBCBQGN-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 239000004576 sand Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivados de los ácidos carboxílicos de la fórmula I en donde R significa tetrazol, nitrilo, un grupo a) Hidrógeno; b) Un grupo succinilimidoxi; c) Un heteroaromato de 5 miembros unido a través de un átomo de nitrógeno como pirrolilo, pirazolilo, imidazolilo y triazolilo, el cual puede tener uno o dos átomos de halógeno, o uno o dos C1 -C4 -alquilo o uno hasta dos grupos C1 -C4 -alcoxi. d) R1 además un grupo donde k asume los valores 0, 1 y 2, p los valores 1, 2, 3 y 4 y R7 representaC1 -C4 -alquilo, C3 -C7 -cicloalquilo, C3 -C6 -alquenilo, C3 -C6 -alquinilo o fenilo eventualmente sustituido, el cual puede estar sustituido por uno o varios, por ejemplo, uno hasta tres de los siguientes radicales: Halógeno, nitro, ciano, C1 -C4 -alquilo, C1 -C4 -halogenalquilo, hidroxi, C1 -C4 -alcoxi, C1 -C4 -alquiltio, mercapto, amino, C1 -C4 - alquilamino, C1 -C4 -dialquilamino; e) R1 además un radical OR8 , en donde R8 significa: hidrógeno, el catión de un metal alcalino como litio, sodio, potasio o el catión de un metal alcalinotérreo - 2 -como calcio, magnesio y bario o un ión amónico orgánico fisiológicamente compatible, como tert. C1 -C4 -alquilamonio o el ión amonico: C3 -C8 -cicloalquilo como ciclopropilo, ciclobutilo, ciclopentilo, ciclohexilo y cicloheptilo, ciclooctilo. C1 -C8 -alquilo especialmente C1 -C4 -alquilo como metilo, etilo, n-propilo, iso-propilo, n-butilo, iso-butilo, tert, -butilo; CH2 -fenilo que puede estar sustituido por uno o varios de los siguientes radicales: halógeno, nitro, ciano, C1 -C4 -alquilo, C1 -C4 -halogenalquilo, hidroxi, C1 -C4 -alcoxi, mercapto, C1 -C4 -alquiltio, amino, C1 -C4 -alquilamino, C1 -C4 -dialquilamino, Un grupo C3 -C6 -alquenilo o C3 -C6 -alquinilo, pudiendo este grupo tener a su vez uno hasta cinco átomos de halógeno; R8 puede ser además un radical fenilo, el cual puede tener uno hasta cinco átomos de halógeno y/o uno hasta tres de los siguientes radicales: nitro, ciano, C1 -C4 -alquilo, C1 -C4 -halogenalquilo, hidroxi, C1 -C4 -alcoxi, mercapto, C1 -C4 -alquiltio, amino, C1 -C4 -alquilamino, C1 -C4 -dialquilamino;Un heteroaromato de 5 miembros ligado a través de un átomo de nitrógeno, que contiene uno a tres átomos de nitrógeno, el cual puede tener uno hasta dos átomos de halógeno y/o uno hasta dos de los siguientes radicales: C1 -C4 -alquilo, C1 -C4 -halogenalquilo, C1 -C4 -alcoxi, fenilo C1 -C4 -halogenalcoxi y/o C1 -C4 -alquiltio. Deben mencionarse especialmente: 1-pirazolilo, 3-metil-1-pirazolilo, 4-metil-1-pirazolilo, 3,5-dimetil-1-pirazolilo, 3-fenil-1-pirazolilo, 4-fenil-l-pirazolilo, 4-cloro-1-pirazolilo, 4-bromo-1-pirazolilo, 1-imidazolilo, 1-bencimidazolilo, l,2,4-triazol-1-ilo, 3-metil-1,2,4-triazol-1-ilo,5-metil-1,2,4-triazol-1-ilo, 1-benztriazolilo, 3,4-diclorimidazol-1-ilo;f) R1 además un radical C1 AND#8209;C4 AND#8209;alquilo, C3 AND#8209;C6 AND#8209;alquinilo, C3 AND#8209;C6 AND#8209;alquinilo, C3 AND#8209;C8 AND#8209;cicloalquilo como se mencionó especialmente antes, pudiendo tener estos radicales un radical C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;alquiltio y/o fenilo, como se menciono antes; fenilo, eventualmente sustituido, especialmente como se menciono antes; g) R1 un radical en el cual R9 tiene el significado antes mencionado; h) además R1 puede significar pudiendo R10 y R11 pueden ser iguales o diferentes y tener el siguiente significado: hidrógeno, C1 AND#8209;C7 AND#8209;alquilo, C3 AND#8209;C7 AND#8209;cicloalquilo, C3 AND#8209;C7 AND#8209;alquenilo, C3 AND#8209;C7 AND#8209;alquinilo, bencilo, fenilo, eventualmente sustituido en la forma antes descrita, o R10 y R11 forman juntos una cadena C4 AND#8209;C7 AND#8209; alquileno, cerrada en forma de anillo, opcionalmente sustituida, por ejemplo, por C1 AND#8209;C4 AND#8209;alquilo, la cual puede tener un heteroátomo, por ejemplo, oxígeno, azufre o nitrógeno como -(CH2 )4 - -(CH2 )5 -, AND#8209;(CH2 )6 AND#8209;, AND#8209;(CH2 )7 AND#8209;, AND#8209;(CH2 )2 AND#8209;OAND#8209;(CH2 )2 AND#8209;, AND#8209;CH2 AND#8209;SAND#8209;(CH2 )2 AND#8209;, -CH2 NH-(CH2 )2 AND#8209;, AND#8209;(CH2 )2 AND#8209;NAND#8209; (CH2 )2 AND#8209;;los demás sustituyentes tienen el siguiente significado: R2 hidrógeno, hidroxi, NH2 NH(C1 AND#8209;C4 AND#8209;alquilo), N(C1 AND#8209;C4 AND#8209;alquilo)2 , halógeno, C1 AND#8209;C4 AND#8209;alquilo, C1 -C4 AND#8209;halogenalquilo, alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi o C1 AND#8209;C4 AND#8209;alquiltio o CR2 junto con CR12 está unido como se indica abajo en un anillo de 5 o 6 miembros; X nitrógeno o CR12 , donde R12 significa o C1-5 o CR12 junto con CR2 o CR3 forman un anillo alquileno o alquenileno de 5 o 6 miembros, que puede estar sustituido por uno o dos grupos C1 AND#8209;C4 AND#8209;alquiloy donde respectivamente un grupo metileno puede estar reemplazado por oxígeno, azufre, NH o AND#8209;NC1-4 AND#8209;alquilo; Y nitrógeno o metina; R3 hidrógeno, hidroxi, NH2 , NH(C1 AND#8209;C4 )AND#8209;alquilo, N(C1 AND#8209;C4 AND#8209;alquilo)2 , halógeno, C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi, NHAND#8209;OAND#8209;C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;alquiltio; o CR3 está junto con CR12 , como se describió antes, unido a un anillo de 5 o 6 miembros; R4 y R5 (que pueden ser iguales o diferentes): fenilo o naftilo, que pueden estar sustituidos por uno o varios de los siguientes radicales: halógeno, nitro, ciano, hidroxi, C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi, fenoxi, C1 AND#8209;C4 AND#8209;alquiltio, amino, C1 AND#8209;C4 AND#8209;alquilamino o DiAND#8209;C1 AND#8209;C4 AND#8209;alquilamino; o fenilo o naftilo, que en posición orto están unidos entre sí por un enlace directo, un grupo metileno, etileno o etenileno, un átomo de oxígeno o de azufre o un grupo SO2 , NH o NAND#8209;alquilo, o C3 AND#8209;C7 AND#8209;cicloalquilo;R6 hidrógeno, C1 AND#8209;C8 AND#8209;alquilo, C3 AND#8209;C6 AND#8209;alquenilo, C3 AND#8209;C6 AND#8209;alquinilo o C3 AND#8209;C8 AND#8209;cicloalquilo, pudiendo estos radicales respectivamente estar sustituidos una o varias veces por: halógeno, hidroxi, mercapto, carboxi, nitro, ciano, C1 AND#8209;C4 AND#8209;alcoxi, C3 AND#8209;C6 AND#8209; alqueniloxi, C3 AND#8209;C6 AND#8209;alquiniloxi, C1 AND#8209;C4 AND#8209;alquiltio, C1 AND#8209;C4 AND#8209;halogenalcoxi, C1 AND#8209;C4 AND#8209;alquilcarbonilo, C1 AND#8209;C4 AND#8209;alcoxicarbonilo, C3-8 AND#8209;alquilcarbonilalquilo, C1 AND#8209;C4 AND#8209;alquilamino, DiAND#8209;C1 AND#8209;C4 AND#8209;alquilamino, fenilo, fenilo o fenoxi, sustituido una o varias veces por ejemplo, una hasta tres veces por halógeno, nitro, ciano, C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenoalcoxi, o C1 AND#8209;C4 AND#8209;alquiltio; fenilo o naftilo que pueden estar sustituidos respectivamente por uno o varios de los siguientes radicales: halógeno, nitro, ciano, hidroxi, amino C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209;halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi, fenoxi, C1 AND#8209;C4 AND#8209;alquiltio, C1 AND#8209;C4 AND#8209;alquilamino, C1 AND#8209;C4 AND#8209;dialquilamino, dioxometileno o dioxoetileno;un heteroaromatoso de 5 o 6 miembros que contiene uno hasta tres átomos de nitrógeno y/o un átomo de azufre o de oxígeno, el cual puede tener uno hasta cuatro átomos halógenos y/o uno hasta dos de los siguientes radicales: C1 AND#8209;C4 AND#8209;alquilo C1 AND#8209;C4 AND#8209;halogenalquilo. C1 AND#8209;C4 AND#8209;alcoxi,C1 AND#8209;C4 AND#8209;halogenalcoxi, C1 AND#8209;C4 AND#8209;alquiltio, fenilo, fenoxi o fenilcarbonilo pudiendo los radicales fenilo a su vez tener uno hasta cinco átomos de halógeno y/o hasta tres de los siguientes radicales: C1 AND#8209;C4 AND#8209;alquilo, C1 AND#8209;C4 AND#8209; halogenalquilo, C1 AND#8209;C4 AND#8209;alcoxi, C1 AND#8209;C4 AND#8209;halogenalcoxi o C1 AND#8209;C4 AND#8209;alquiltio; Z azufre u oxígeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19614542A DE19614542A1 (de) | 1996-04-12 | 1996-04-12 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
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| Publication Number | Publication Date |
|---|---|
| CO4900038A1 true CO4900038A1 (es) | 2000-03-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97018895A CO4900038A1 (es) | 1996-04-12 | 1997-04-11 | Nuevos derivados de acidos carboxilicos, su obtencion y aplicacion |
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| Country | Link |
|---|---|
| US (1) | US6103732A (es) |
| EP (1) | EP0892788A1 (es) |
| JP (1) | JP2000508325A (es) |
| KR (1) | KR20000005366A (es) |
| CN (1) | CN1216042A (es) |
| AR (1) | AR006593A1 (es) |
| AU (1) | AU711293B2 (es) |
| BG (1) | BG63202B1 (es) |
| BR (1) | BR9708614A (es) |
| CA (1) | CA2250764A1 (es) |
| CO (1) | CO4900038A1 (es) |
| DE (1) | DE19614542A1 (es) |
| HR (1) | HRP970200A2 (es) |
| ID (1) | ID19050A (es) |
| IL (1) | IL126026A0 (es) |
| NO (1) | NO311802B1 (es) |
| NZ (1) | NZ331704A (es) |
| PL (1) | PL329240A1 (es) |
| SK (1) | SK127698A3 (es) |
| TR (1) | TR199802042T2 (es) |
| TW (1) | TW419465B (es) |
| WO (1) | WO1997038982A1 (es) |
| ZA (1) | ZA973096B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL130251A0 (en) | 1996-12-18 | 2000-06-01 | Basf Ag | Heterocyclic carboxylic acid derivatives the production and use thereof as endothelin receptor antagonists |
| US6030975A (en) * | 1997-03-14 | 2000-02-29 | Basf Aktiengesellschaft | Carboxylic acid derivatives, their preparation and use in treating cancer |
| HUP0004935A3 (en) * | 1997-09-04 | 2001-12-28 | Basf Ag | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists |
| DE69838042T2 (de) * | 1997-10-17 | 2008-03-06 | Ark Therapeutics Ltd. | Verwendung von Inhibitoren des Renin-Angiotensin Systems |
| US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
| DE60120104T2 (de) * | 2001-03-20 | 2006-09-21 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
| DE60100055T2 (de) * | 2001-03-21 | 2003-07-24 | Sanol Arznei Schwarz Gmbh | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| WO2005099740A1 (en) | 2004-04-16 | 2005-10-27 | Schwarz Pharma Ag | Use of peptidic compounds for the prophylaxis and treatment of chronic headache |
| JP2008510758A (ja) * | 2004-08-27 | 2008-04-10 | シュヴァルツ・ファーマ・アーゲー | 骨肉腫の痛み、化学療法誘発性及びヌクレオシド誘発性の痛みを治療するためのペプチド化合物の新規使用 |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| JP5443981B2 (ja) | 2006-06-15 | 2014-03-19 | ウーツェーベー ファルマ ゲーエムベーハー | 相乗的抗痙攣効果を有する医薬組成物 |
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| AU2882195A (en) * | 1994-06-27 | 1996-01-19 | Ciba-Geigy Ag | Pyrimidinyl- and triazinyl-oxy and thio-3-haloalkyl-propionic acid derivatives as herbicides |
-
1996
- 1996-04-12 DE DE19614542A patent/DE19614542A1/de not_active Withdrawn
-
1997
- 1997-04-04 WO PCT/EP1997/001687 patent/WO1997038982A1/de not_active Application Discontinuation
- 1997-04-04 EP EP97918109A patent/EP0892788A1/de not_active Withdrawn
- 1997-04-04 PL PL97329240A patent/PL329240A1/xx unknown
- 1997-04-04 CN CN97193737A patent/CN1216042A/zh active Pending
- 1997-04-04 KR KR1019980708088A patent/KR20000005366A/ko not_active Application Discontinuation
- 1997-04-04 BR BR9708614A patent/BR9708614A/pt not_active IP Right Cessation
- 1997-04-04 US US09/155,948 patent/US6103732A/en not_active Expired - Fee Related
- 1997-04-04 JP JP9536698A patent/JP2000508325A/ja active Pending
- 1997-04-04 TR TR1998/02042T patent/TR199802042T2/xx unknown
- 1997-04-04 CA CA002250764A patent/CA2250764A1/en not_active Abandoned
- 1997-04-04 AU AU26364/97A patent/AU711293B2/en not_active Ceased
- 1997-04-04 NZ NZ331704A patent/NZ331704A/en unknown
- 1997-04-04 SK SK1276-98A patent/SK127698A3/sk unknown
- 1997-04-04 IL IL12602697A patent/IL126026A0/xx unknown
- 1997-04-10 AR ARP970101432A patent/AR006593A1/es not_active Application Discontinuation
- 1997-04-11 TW TW086104674A patent/TW419465B/zh not_active IP Right Cessation
- 1997-04-11 HR HR19614542.2A patent/HRP970200A2/xx not_active Application Discontinuation
- 1997-04-11 ZA ZA973096A patent/ZA973096B/xx unknown
- 1997-04-11 CO CO97018895A patent/CO4900038A1/es unknown
- 1997-04-14 ID IDP971240A patent/ID19050A/id unknown
-
1998
- 1998-09-15 BG BG102770A patent/BG63202B1/bg unknown
- 1998-10-09 NO NO19984713A patent/NO311802B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6103732A (en) | 2000-08-15 |
| BR9708614A (pt) | 1999-08-03 |
| ID19050A (id) | 1998-06-04 |
| BG102770A (en) | 1999-11-30 |
| HRP970200A2 (en) | 1998-04-30 |
| NO311802B1 (no) | 2002-01-28 |
| AU711293B2 (en) | 1999-10-07 |
| NO984713D0 (no) | 1998-10-09 |
| BG63202B1 (bg) | 2001-06-29 |
| ZA973096B (en) | 1998-10-12 |
| AU2636497A (en) | 1997-11-07 |
| CN1216042A (zh) | 1999-05-05 |
| KR20000005366A (ko) | 2000-01-25 |
| DE19614542A1 (de) | 1997-10-16 |
| NZ331704A (en) | 2000-06-23 |
| NO984713L (no) | 1998-10-09 |
| WO1997038982A1 (de) | 1997-10-23 |
| AR006593A1 (es) | 1999-09-08 |
| IL126026A0 (en) | 1999-05-09 |
| TR199802042T2 (xx) | 2000-09-21 |
| JP2000508325A (ja) | 2000-07-04 |
| TW419465B (en) | 2001-01-21 |
| PL329240A1 (en) | 1999-03-15 |
| CA2250764A1 (en) | 1997-10-23 |
| SK127698A3 (en) | 2000-03-13 |
| EP0892788A1 (de) | 1999-01-27 |
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