AR015962A1 - LANTIBIoTICO RELACIONADO CON ACTAGARDINA, PROCEDIMIENTO PARA SU PREPARACIoN, MEDICAMENTO, PROCEDIMIENTO PARA LA PREPARACIoN DE UN MEDICAMENTO Y EMPLEO DEL MISMO PARA LA PREPARACIoN DE UN MEDICAMENTO PARA ENFERMEDADES INFECCIOSAS BACTERIANAS. - Google Patents
LANTIBIoTICO RELACIONADO CON ACTAGARDINA, PROCEDIMIENTO PARA SU PREPARACIoN, MEDICAMENTO, PROCEDIMIENTO PARA LA PREPARACIoN DE UN MEDICAMENTO Y EMPLEO DEL MISMO PARA LA PREPARACIoN DE UN MEDICAMENTO PARA ENFERMEDADES INFECCIOSAS BACTERIANAS.Info
- Publication number
- AR015962A1 AR015962A1 ARP980105093A ARP980105093A AR015962A1 AR 015962 A1 AR015962 A1 AR 015962A1 AR P980105093 A ARP980105093 A AR P980105093A AR P980105093 A ARP980105093 A AR P980105093A AR 015962 A1 AR015962 A1 AR 015962A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- procedure
- medicinal product
- lantibiotic
- actagardine
- Prior art date
Links
- 108010062877 Bacteriocins Proteins 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 2
- 208000035473 Communicable disease Diseases 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 108010070411 gardimycin Proteins 0.000 title 1
- LAWKVNVCUPIOMG-HWWYPGLISA-N gardimycin Chemical compound C1=CC=C2C(C[C@H](C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@H](CC)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(O)=O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](CC)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)N)[C@@H](C)CC)C(C)C)=CNC2=C1 LAWKVNVCUPIOMG-HWWYPGLISA-N 0.000 title 1
- 241000983982 Actinoplanes liguriensis Species 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente se refiere a un nuevo lantibiotico con la formula NH2-R-actagardina, significando NH2-R el resto del aminoácido alanina, que se forma durantela fermentacion por el microorganismo Actinoplanes liguriae DSM 11797 o Actinoplanesgarbadiensis DSM 11796, a derivados químicos del lantibiotico, a unprocedimiento para su preparacion y al empleo de los lantibioticos como medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19745583A DE19745583A1 (de) | 1997-10-15 | 1997-10-15 | Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015962A1 true AR015962A1 (es) | 2001-05-30 |
Family
ID=7845627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105093A AR015962A1 (es) | 1997-10-15 | 1998-10-13 | LANTIBIoTICO RELACIONADO CON ACTAGARDINA, PROCEDIMIENTO PARA SU PREPARACIoN, MEDICAMENTO, PROCEDIMIENTO PARA LA PREPARACIoN DE UN MEDICAMENTO Y EMPLEO DEL MISMO PARA LA PREPARACIoN DE UN MEDICAMENTO PARA ENFERMEDADES INFECCIOSAS BACTERIANAS. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6022851A (es) |
| EP (1) | EP0916680B1 (es) |
| JP (1) | JP3684432B2 (es) |
| KR (1) | KR100482402B1 (es) |
| CN (1) | CN1165547C (es) |
| AR (1) | AR015962A1 (es) |
| AT (1) | ATE258558T1 (es) |
| AU (1) | AU739516C (es) |
| BR (1) | BRPI9803914B1 (es) |
| CA (1) | CA2250630C (es) |
| DE (2) | DE19745583A1 (es) |
| DK (1) | DK0916680T3 (es) |
| ES (1) | ES2213862T3 (es) |
| HK (1) | HK1020739A1 (es) |
| PT (1) | PT916680E (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861236B2 (en) * | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| EP1908774A1 (en) * | 2006-10-06 | 2008-04-09 | sanofi-aventis | Antibacterial and antiviral peptides from Actinomadura namibiensis |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| WO2010058238A1 (en) * | 2008-11-24 | 2010-05-27 | Sentinella Pharmaceuticals, Inc. ("Sentinella") | Lantibiotic carboxyamide derivatives with enhanced antibacterial activity |
| GB0900599D0 (en) * | 2009-01-14 | 2009-02-18 | Novacta Biosystems Ltd | Treatment |
| JP5719312B2 (ja) | 2009-01-14 | 2015-05-13 | ノヴァクタ バイオシステムズ リミティッド | デオキシアクタガルジン誘導体 |
| CA2750883A1 (en) | 2009-02-04 | 2010-08-12 | Novacta Biosystems Limited | Actagardine derivatives |
| GB201001688D0 (en) * | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
| EP2701718A4 (en) * | 2011-03-30 | 2014-11-19 | Sentinella Pharmaceuticals Inc | LANTIBIOTIC NAI-802, PHARMACEUTICALLY ACCEPTABLE SALTS, ITS COMPOSITIONS, AND USES THEREOF |
| AU2015237357B2 (en) * | 2014-03-25 | 2019-04-18 | Lanthiopep B.V. | Cyclic apelin analogs |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1470407A (en) * | 1974-07-27 | 1977-04-14 | Lepetit Spa | Antibiotic substances |
| GB8507528D0 (en) * | 1985-03-22 | 1985-05-01 | Lepetit Spa | Basis monocarboxyamide derivatives |
| US5512269A (en) * | 1993-06-09 | 1996-04-30 | Burroughs Wellcome, Co. | Method of treating retained pulmonary secretions |
-
1997
- 1997-10-15 DE DE19745583A patent/DE19745583A1/de not_active Withdrawn
-
1998
- 1998-10-09 DK DK98119105T patent/DK0916680T3/da active
- 1998-10-09 DE DE59810658T patent/DE59810658D1/de not_active Expired - Lifetime
- 1998-10-09 AT AT98119105T patent/ATE258558T1/de active
- 1998-10-09 ES ES98119105T patent/ES2213862T3/es not_active Expired - Lifetime
- 1998-10-09 EP EP98119105A patent/EP0916680B1/de not_active Expired - Lifetime
- 1998-10-09 PT PT98119105T patent/PT916680E/pt unknown
- 1998-10-13 CA CA002250630A patent/CA2250630C/en not_active Expired - Fee Related
- 1998-10-13 AU AU89261/98A patent/AU739516C/en not_active Ceased
- 1998-10-13 AR ARP980105093A patent/AR015962A1/es active IP Right Grant
- 1998-10-14 JP JP29202498A patent/JP3684432B2/ja not_active Expired - Fee Related
- 1998-10-14 US US09/172,042 patent/US6022851A/en not_active Expired - Lifetime
- 1998-10-15 BR BRPI9803914A patent/BRPI9803914B1/pt not_active IP Right Cessation
- 1998-10-15 CN CNB981241085A patent/CN1165547C/zh not_active Expired - Fee Related
- 1998-10-15 KR KR10-1998-0043572A patent/KR100482402B1/ko not_active IP Right Cessation
-
1999
- 1999-12-03 HK HK99105659A patent/HK1020739A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1020739A1 (en) | 2000-05-19 |
| KR100482402B1 (ko) | 2005-08-31 |
| JP3684432B2 (ja) | 2005-08-17 |
| AU739516B2 (en) | 2001-10-11 |
| US6022851A (en) | 2000-02-08 |
| DE19745583A1 (de) | 1999-04-22 |
| CN1165547C (zh) | 2004-09-08 |
| EP0916680B1 (de) | 2004-01-28 |
| CA2250630A1 (en) | 1999-04-15 |
| BR9803914A (pt) | 2000-03-28 |
| DK0916680T3 (da) | 2004-05-24 |
| EP0916680A3 (de) | 2001-10-17 |
| EP0916680A2 (de) | 1999-05-19 |
| BRPI9803914B1 (pt) | 2016-11-01 |
| KR19990037179A (ko) | 1999-05-25 |
| DE59810658D1 (de) | 2004-03-04 |
| ATE258558T1 (de) | 2004-02-15 |
| PT916680E (pt) | 2004-06-30 |
| JPH11193299A (ja) | 1999-07-21 |
| CA2250630C (en) | 2008-07-15 |
| AU739516C (en) | 2002-05-02 |
| ES2213862T3 (es) | 2004-09-01 |
| AU8926198A (en) | 1999-05-06 |
| CN1221752A (zh) | 1999-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |