GB1224658A - Cyclic decapeptides - Google Patents

Cyclic decapeptides

Info

Publication number
GB1224658A
GB1224658A GB49294/68A GB4929468A GB1224658A GB 1224658 A GB1224658 A GB 1224658A GB 49294/68 A GB49294/68 A GB 49294/68A GB 4929468 A GB4929468 A GB 4929468A GB 1224658 A GB1224658 A GB 1224658A
Authority
GB
United Kingdom
Prior art keywords
phe
pro
ome
boc
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49294/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1967B0094980 external-priority patent/DE1643251C3/en
Application filed by CH Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH filed Critical CH Boehringer Sohn AG and Co KG
Publication of GB1224658A publication Critical patent/GB1224658A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1,224,658. Cyclic peptide. BOEHRINGER INGELHEIM G.m.b.H. 17 Oct., 1968 [17 Oct., 1967; 12 Aug., 1968], No. 49294/68. Heading C2C. Novel peptides of Formula I in which Y is ala, gly or D-ala, are prepared by cyclization of the corresponding straight chain peptides. Intermediates isolated are CBO-phe-phe-OMe, H - phe - phe - OMe.HCl, CBO - pro - pro - OMe, CBO - pro - pro - OH, CBO - pro - pro - phephe - OMe, H - pro - pro - phe - phe - OMe, BOC - phe - pro - pro - phe - phe - OH, BOC- ala - phe - OMe, H - ala - phe - OMe, BOC - proala - phe - OMe, H - pro - ala - phe - OMe, BOC - val - pro - OMe, BOC - val - pro - OH, BOC - val - pro - pro - ala - phe - OMe, H - valpro - pro - ala - phe - OMe, BOC - phe - pro - prophe - phe - val - pro - pro - ala - phe - OMe, H - phe - pro - pro - phe - phe - val - pro - proala - phe - OH, BOC - pro - gly - OMe, H - progly - OMe.HCl, BOC - val - pro - pro - gly-OMe, H - val - pro - pro - gly - OMe.HCl, BOC - phephe - OMe, H - phe - phe - OMe.HCl, BOC- pro - phe - phe - OMe - H - pro - phe - phe- OMe.HCl, BOC - phe - pro - OMe, BOC - phepro - OH, BOC - phe - pro - pro - phe - phe- OMe, BOC - phe - phe - pro - pro - phe - phe- OMe, BOC - phe - phe - pro - pro - phe - phe- OH, BOC - phe - phe - pro - pro - phe - pheval - pro -pro - gly - OMe, and H - phe - phepro - pro phe - phe - val - pro - pro - gly - OH.- Pharmaceutical compositions comprise a compound I in conjunction with a suitable excipient for oral administration and have prophylactic activity.
GB49294/68A 1967-10-17 1968-10-17 Cyclic decapeptides Expired GB1224658A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1967B0094980 DE1643251C3 (en) 1967-10-17 1967-10-17 Cyclic decapeptide antamanide, process for its preparation and its pharmaceutical composition
DE1643251 1967-10-17
DE19681793180 DE1793180A1 (en) 1967-10-17 1968-08-12 Derivatives of antamanide

Publications (1)

Publication Number Publication Date
GB1224658A true GB1224658A (en) 1971-03-10

Family

ID=27180966

Family Applications (1)

Application Number Title Priority Date Filing Date
GB49294/68A Expired GB1224658A (en) 1967-10-17 1968-10-17 Cyclic decapeptides

Country Status (3)

Country Link
CH (1) CH505790A (en)
FR (1) FR8408M (en)
GB (1) GB1224658A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004269A1 (en) * 1989-09-22 1991-04-04 Ferring Ab Medicament comprising antamanide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1101843A (en) * 1976-08-02 1981-05-26 Daniel F. Veber Cyclic hexapeptides useful for increasing feed efficiency

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004269A1 (en) * 1989-09-22 1991-04-04 Ferring Ab Medicament comprising antamanide

Also Published As

Publication number Publication date
CH505790A (en) 1971-04-15
FR8408M (en) 1971-03-31

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