KR870010080A - Tripeptide with immunostimulatory activity - Google Patents

Tripeptide with immunostimulatory activity Download PDF

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Publication number
KR870010080A
KR870010080A KR870003455A KR870003455A KR870010080A KR 870010080 A KR870010080 A KR 870010080A KR 870003455 A KR870003455 A KR 870003455A KR 870003455 A KR870003455 A KR 870003455A KR 870010080 A KR870010080 A KR 870010080A
Authority
KR
South Korea
Prior art keywords
tripeptide
immunostimulatory activity
arg
ala
trifluoroacetate
Prior art date
Application number
KR870003455A
Other languages
Korean (ko)
Inventor
브루네티 부루네토
프라다 마르코
Original Assignee
로베르트 비안치
엘렌 인더스트리아 파마슈티카 에스. 페. 아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로베르트 비안치, 엘렌 인더스트리아 파마슈티카 에스. 페. 아 filed Critical 로베르트 비안치
Publication of KR870010080A publication Critical patent/KR870010080A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

내용 없음No content

Description

면역촉진 활성을 갖는 트리펩티드Tripeptide with immunostimulatory activity

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 트리펩티드의 HPLC 윤곽을 나타내는 스펙트럼도Figure 1 is a spectral diagram showing the HPLC contour of tripeptide

Claims (5)

L-Ala(알라닌)과 2L-Arg(알지닌)으로 구성되어 있으며, 다음 구조Arg-Ala-Arg를 가짐을 특징으로 하는 트리펩티드.A tripeptide comprising L-Ala (alanine) and 2L-Arg (arginine) and having the following structure Arg-Ala-Arg. 제1항에 있어서, 면역촉진 활성을 가짐을 특징으로 하는 트리펩티드.The tripeptide according to claim 1, having immunostimulatory activity. 제1항에 있어서, 면역시스템의 일차결핍 및 이차결핍으로 특색지워진 병세에서, 약품으로써 가능한 치료용도를 가짐을 특징으로 하는 트리펩티드.The tripeptide according to claim 1, wherein the tripeptide has a possible therapeutic use as a drug in a condition characterized by primary and secondary deficiency of the immune system. 제1항에 있어서, 비경구성 투여 및 경구성 투여 후 면역자극 활성에 쓰일 수 있음을 특징으로 하는 트리펩티드.The tripeptide according to claim 1, which can be used for immunostimulatory activity after parenteral administration and oral administration. 제3항에 있어서, 예를 들어 아세테이트, 트리플루오르아세테이트, 염산염, 술페이트 같이, 약품으로 사용 가능한 제약적으로 수용할 수 있는 트리펩티드염.4. A pharmaceutically acceptable tripeptide salt according to claim 3 for use as a medicament, such as, for example, acetate, trifluoroacetate, hydrochloride, sulfate. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR870003455A 1986-04-09 1987-04-09 Tripeptide with immunostimulatory activity KR870010080A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20027/86A IT1188646B (en) 1986-04-09 1986-04-09 TRIPEPTIDE WITH IMMUNOSTIMULANT ACTIVITY
IT20027A 1986-04-09

Publications (1)

Publication Number Publication Date
KR870010080A true KR870010080A (en) 1987-11-30

Family

ID=11163225

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870003455A KR870010080A (en) 1986-04-09 1987-04-09 Tripeptide with immunostimulatory activity

Country Status (17)

Country Link
JP (1) JPH0645637B2 (en)
KR (1) KR870010080A (en)
AR (1) AR242799A1 (en)
AT (1) ATA88387A (en)
AU (1) AU597048B2 (en)
BE (1) BE1000263A4 (en)
CA (1) CA1322715C (en)
CH (1) CH676467A5 (en)
DE (1) DE3712050A1 (en)
ES (1) ES2003043A6 (en)
FR (1) FR2597107B1 (en)
GB (1) GB2189491B (en)
GR (1) GR870568B (en)
IE (1) IE59806B1 (en)
IT (1) IT1188646B (en)
NL (1) NL8700827A (en)
SE (1) SE8701457L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2058553C1 (en) * 1994-03-18 1996-04-20 Иван Николаевич Головистиков Method of estimation of human immune status suppressive link
RU2056852C1 (en) * 1994-03-18 1996-03-27 Иван Николаевич Головистиков Agent for treatment of autoimmune diseases with suppressor immunodeficiency and a method of autoimmune diseases treatment
GB0130286D0 (en) * 2001-12-19 2002-02-06 Astrazeneca Ab Chemical process
GB0130285D0 (en) * 2001-12-19 2002-02-06 Astrazeneca Ab Chemical process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3778426A (en) * 1970-12-16 1973-12-11 Research Corp Therapeutically useful polypeptides
US4215112A (en) * 1979-03-14 1980-07-29 Ortho Pharmaceutical Corporation Tripeptides and methods

Also Published As

Publication number Publication date
IT1188646B (en) 1988-01-20
AU597048B2 (en) 1990-05-24
IE59806B1 (en) 1994-04-06
DE3712050C2 (en) 1992-02-13
ES2003043A6 (en) 1988-10-01
IE870881L (en) 1987-10-09
NL8700827A (en) 1987-11-02
IT8620027A0 (en) 1986-04-09
CA1322715C (en) 1993-10-05
GB2189491A (en) 1987-10-28
DE3712050A1 (en) 1987-10-15
GR870568B (en) 1987-08-12
AU7118287A (en) 1987-10-15
FR2597107B1 (en) 1991-02-22
BE1000263A4 (en) 1988-09-27
SE8701457D0 (en) 1987-04-07
JPH0645637B2 (en) 1994-06-15
IT8620027A1 (en) 1987-10-09
GB2189491B (en) 1990-02-21
JPS62267296A (en) 1987-11-19
CH676467A5 (en) 1991-01-31
ATA88387A (en) 1996-05-15
SE8701457L (en) 1987-10-10
FR2597107A1 (en) 1987-10-16
AR242799A1 (en) 1993-05-31
GB8708492D0 (en) 1987-05-13

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E902 Notification of reason for refusal
E601 Decision to refuse application