AR015469A1 - Acido alquil-carboxilico beta-aril-alfa-oxisubstituido, su uso en la manufactura de un medicamento, procedimiento para su preparacion, composiciones farmaceuticas que los contienen, compuestos intermediarios y procedimiento para su preparacion - Google Patents

Acido alquil-carboxilico beta-aril-alfa-oxisubstituido, su uso en la manufactura de un medicamento, procedimiento para su preparacion, composiciones farmaceuticas que los contienen, compuestos intermediarios y procedimiento para su preparacion

Info

Publication number
AR015469A1
AR015469A1 ARP980105381A ARP980105381A AR015469A1 AR 015469 A1 AR015469 A1 AR 015469A1 AR P980105381 A ARP980105381 A AR P980105381A AR P980105381 A ARP980105381 A AR P980105381A AR 015469 A1 AR015469 A1 AR 015469A1
Authority
AR
Argentina
Prior art keywords
procedure
preparation
alkoxy
aryl
derivatives
Prior art date
Application number
ARP980105381A
Other languages
English (en)
Original Assignee
Reddys Lab Ltd Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr filed Critical Reddys Lab Ltd Dr
Publication of AR015469A1 publication Critical patent/AR015469A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Acido alquilcarboxílico beta-aril-alfa-oxisustituido que tiene la formula (I), sus derivados, sus análogos, sus formas tautoméricas, sus estereoisomeros,sus polimorfos, sus sales farmacéuticamente aceptables, sus solvatos farmacéuticamenteaceptables , donde los grupos R1, R2, R3, R4, y los grupos R5 y R6 cuandoestán unidos a un átomo de carbono, pueden ser iguales o diferentes y representan hidrogeno, halogeno, hidroxi, nitro, ciano, formilo o grupos opcionalmentesubstituidosseleccionados de al quilo, cicloalquilo, alcoxi, cicloalcoxi, arilo, ariloxi, aralquilo, aralcoxi, heterociclilo, heteroarilo, heteroaralquilo,heteroariloxi, heteroaralcoxi, acilo, aciloxi, hidroxialquilo, amino, acilamino, alquilamino, arilamino,aralquilamino, aminoal quilo, alcoxicarbonilo,ariloxicarbonilo, aralcoxicarbonilo, alcoxialquilo, ariloxialquilo, aralcoxialquilo, alquiltio, tioalquilo, alcoxicarbonilamino, ariloxicarbonilalmino,aralcoxicarbonilamino, ácido carboxílico o susderivados, o ácido sulfonico o sus derivados; uno o ambos de R5 y R6 puede representar un grupo oxo cuando estáunido a un átomo de C; R5 y R6 cuando están unidos a un átomo de nitrogeno representan hidrogeno, hidroxi, formilo o grupos opcionalmentesubstituidosseleccionados de a lquilo, cicloalquilo, alcoxi, cicloalcoxi, arilo, aralquilo, heterociclilo, heteroarilo, heteroaralquilo, acilo, aciloxi, hidroxialquilo,amino, acilamino, alquilamino, arilamino, aralquilamino, aminoalquilo, ariloxi,aralcoxi, heteroariloxi, heteroar alcoxi, alcoxicarbonilo, ariloxicarbonilo,aralcoxicarbonilo, alcoxialquilo, ariloxialquilo, aralcoxialquilo, alquiltio, tioalquilo, derivados de ácido carboxílico, o derivados de ácico sulfonico; Xrepresenta unheteroátomo seleccionado de oxígeno, az ufre o NR11 donde R11 está seleccionado de hidrogeno o de grupos opcionalmente substituidos seleccionadosde grupos alquilo, cicloalquilo, arilo, aralquilo, acilo, alcoxicarbonilo, ariloxicarbonilo oaralcoxicarbonilo; Ar representa un grupo aromático oheterocíclico simple o fusionado divalente opcionalmente substituido; R7 representa un átomo de hidrogeno, hidroxi, alcoxi, halogeno, alquilo inferior, un
ARP980105381A 1997-10-27 1998-10-27 Acido alquil-carboxilico beta-aril-alfa-oxisubstituido, su uso en la manufactura de un medicamento, procedimiento para su preparacion, composiciones farmaceuticas que los contienen, compuestos intermediarios y procedimiento para su preparacion AR015469A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2417MA1997 1997-10-27
US09/085,292 US6265401B1 (en) 1997-10-27 1998-05-27 Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AR015469A1 true AR015469A1 (es) 2001-05-02

Family

ID=11096892

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105381A AR015469A1 (es) 1997-10-27 1998-10-27 Acido alquil-carboxilico beta-aril-alfa-oxisubstituido, su uso en la manufactura de un medicamento, procedimiento para su preparacion, composiciones farmaceuticas que los contienen, compuestos intermediarios y procedimiento para su preparacion

Country Status (6)

Country Link
US (1) US6265401B1 (es)
KR (1) KR100617366B1 (es)
AR (1) AR015469A1 (es)
MY (1) MY130757A (es)
UA (1) UA72883C2 (es)
ZA (1) ZA989781B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU752059B2 (en) * 1997-10-27 2002-09-05 Dr. Reddy's Laboratories Limited Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
CA2307820C (en) * 1997-10-27 2007-04-24 Dr. Reddy's Research Foundation Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
WO2000066572A1 (en) * 1999-04-28 2000-11-09 Dr. Reddy's Research Foundation Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents
MXPA02009869A (es) * 2000-04-12 2005-02-17 Judy Raucy Composiciones y metodos para induccion de proteinas involucradas en metabolismo xenobiotico.
US6987123B2 (en) * 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
KR20030024763A (ko) * 2003-03-06 2003-03-26 주식회사 바이오비젠 골다공증 예방 및 치료용 화합물
CA2621164A1 (en) * 2005-08-26 2007-03-01 Shionogi & Co., Ltd. Derivative having ppar agonistic activity
EP2155769B1 (en) * 2007-05-04 2012-06-27 Katholieke Universiteit Leuven KU Leuven Research & Development Tissue degeneration protection
CN115043782B (zh) * 2022-06-01 2023-08-08 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 4h-3,1-苯并噁嗪-4-酮衍生物及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173350B1 (da) 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
CA2035147A1 (en) 1990-02-08 1991-08-09 Kousuke Yasuda Thiazine (or oxazine) derivatives and preparation thereof
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
JPH05194236A (ja) 1991-07-25 1993-08-03 Tanabe Seiyaku Co Ltd 中枢性カルシウム拮抗剤
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
PL176885B1 (pl) 1992-07-03 1999-08-31 Smithkline Beecham Plc Kompozycja farmaceutyczna
WO1994012181A1 (en) * 1992-12-01 1994-06-09 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9225386D0 (en) 1992-12-04 1993-01-27 Smithkline Beecham Plc Novel compounds
US5478852C1 (en) * 1993-09-15 2001-03-13 Sankyo Co Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
GB9326171D0 (en) 1993-12-22 1994-02-23 Smithkline Beecham Plc Novel compounds
US5594015A (en) * 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
BR9508468A (pt) 1994-07-29 1997-11-25 Smithkline Beecham Plc Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário
JPH0912575A (ja) 1995-06-28 1997-01-14 Sankyo Co Ltd ベンゾオキサジンおよびベンゾチアジン誘導体
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HUP0301101A3 (en) 1996-12-31 2009-03-30 Reddy S Res Foundation Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
EP0903343B1 (en) * 1997-09-19 2003-05-28 SSP Co., Ltd. Alpha-Substituted phenylpropionic acid derivative and medicine containing the same

Also Published As

Publication number Publication date
KR100617366B1 (ko) 2006-08-31
ZA989781B (en) 1999-08-25
KR20010031531A (ko) 2001-04-16
UA72883C2 (uk) 2005-05-16
MY130757A (en) 2007-07-31
US6265401B1 (en) 2001-07-24

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