AR010260A1 - Compuestos derivados de 1-(2-metoxifenil)-4-(fenoxialquilen)-piperazina; composiciones farmaceuticas que los contienen; un proceso para la preparacionde dichos compuestos y composiciones farmaceuticas y uso de dicho compuestos - Google Patents
Compuestos derivados de 1-(2-metoxifenil)-4-(fenoxialquilen)-piperazina; composiciones farmaceuticas que los contienen; un proceso para la preparacionde dichos compuestos y composiciones farmaceuticas y uso de dicho compuestosInfo
- Publication number
- AR010260A1 AR010260A1 ARP970105061A ARP970105061A AR010260A1 AR 010260 A1 AR010260 A1 AR 010260A1 AR P970105061 A ARP970105061 A AR P970105061A AR P970105061 A ARP970105061 A AR P970105061A AR 010260 A1 AR010260 A1 AR 010260A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pharmaceutical compositions
- preparation
- imidazo
- fenoxialquilen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- -1 2-imidazo [1,2-a] pyridinyl Chemical group 0.000 abstract 3
- LCCQUAVRRQQTLG-UHFFFAOYSA-N 2,3-dihydroimidazo[2,1-b][1,3]thiazole Chemical compound C1=CN=C2SCCN21 LCCQUAVRRQQTLG-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000027626 Neurocognitive disease Diseases 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 abstract 1
- 239000000203 mixture Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 208000022821 personality disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos heterocíclicos fusionados por medio de un anillo ligante que contiene átomos de nitrogeno de formula (I), donde Q es un grupo 2-(indolizinilo, 2-imidazo[1,2-a]piridinilo, 2-imidazo[1,2-a]pirimidinilo, 6-(2,3 -dihidroimidazo[2,1-b]tiazol)-ilo o 6-imidazo[2,1-b]tiazolilo; y n es unnumero entero entre 2 y 4; así como las sales de los mismos que son de utilidad para usos terapéuticos. Además con composiciones farmacéuticas que contienenestos compuestos, así como con un proceso para lapreparacion de los compuestos y composiciones mencionados. Los nuevos compuestos de formula (I)muestran principalmente efectos antipsicoticos de manera que también se relaciona con un método de tratamiento de esquizofrenia, trastornos mentalesorgánicos, trastornos afectivos, ansiedad y trastornos de la personalidad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9603001A HUP9603001A3 (en) | 1996-10-30 | 1996-10-30 | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010260A1 true AR010260A1 (es) | 2000-06-07 |
Family
ID=89994394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105061A AR010260A1 (es) | 1996-10-30 | 1997-10-31 | Compuestos derivados de 1-(2-metoxifenil)-4-(fenoxialquilen)-piperazina; composiciones farmaceuticas que los contienen; un proceso para la preparacionde dichos compuestos y composiciones farmaceuticas y uso de dicho compuestos |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6103724A (es) |
| EP (1) | EP0935599A1 (es) |
| JP (1) | JP2001503048A (es) |
| KR (1) | KR20000052872A (es) |
| CN (1) | CN1235606A (es) |
| AP (1) | AP9901532A0 (es) |
| AR (1) | AR010260A1 (es) |
| AU (1) | AU4962097A (es) |
| BG (1) | BG103370A (es) |
| BR (1) | BR9712588A (es) |
| CA (1) | CA2269814A1 (es) |
| CZ (1) | CZ132099A3 (es) |
| EA (1) | EA199900433A1 (es) |
| EE (1) | EE9900182A (es) |
| HU (1) | HUP9603001A3 (es) |
| IL (1) | IL129418A0 (es) |
| IS (1) | IS5026A (es) |
| NO (1) | NO992059D0 (es) |
| OA (1) | OA11041A (es) |
| PL (1) | PL333076A1 (es) |
| SK (1) | SK49499A3 (es) |
| TR (1) | TR199900946T2 (es) |
| TW (1) | TW406083B (es) |
| WO (1) | WO1998018797A1 (es) |
| ZA (1) | ZA979617B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2383327C (en) * | 1999-09-14 | 2009-11-03 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| SK3512002A3 (en) * | 1999-09-14 | 2003-03-04 | Aventis Pharma Inc | Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| EP1268478B1 (en) | 2000-03-31 | 2007-05-02 | Ortho-McNeil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
| TW200811175A (en) * | 2006-06-21 | 2008-03-01 | Nihon Mediphysics Co Ltd | Novel compound with affinity with amyloid |
| KR20100091965A (ko) * | 2007-10-24 | 2010-08-19 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
| CA2704027A1 (en) * | 2007-10-26 | 2009-04-30 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| US7985752B2 (en) | 2008-05-29 | 2011-07-26 | Sk Holdings Co., Ltd. | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof |
| US7964605B2 (en) | 2008-05-29 | 2011-06-21 | Sk Holdings Co., Ltd. | Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof |
| CN106187873B (zh) * | 2016-07-25 | 2019-11-05 | 宜春学院 | 一种芳胺基烷基氧类化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880824A (en) * | 1987-09-21 | 1989-11-14 | Ortho Pharmaceutical Corporation | Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers |
| US5688949A (en) * | 1991-04-22 | 1997-11-18 | Otsuka Pharmaceutical Factory, Inc. | Pyrazolo 1,5-A!pyrimidine derivatives and anti-inflammatory agent containing the same |
| US5486517A (en) * | 1994-05-10 | 1996-01-23 | Warner-Lambert Company | Benzimidazoles and imidazopyridines as central nervous system agents |
| US6013654A (en) * | 1997-08-14 | 2000-01-11 | Pharmacia & Upjohn Company | Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases |
-
1996
- 1996-10-30 HU HU9603001A patent/HUP9603001A3/hu unknown
-
1997
- 1997-10-22 CN CN97199313A patent/CN1235606A/zh active Pending
- 1997-10-22 SK SK494-99A patent/SK49499A3/sk unknown
- 1997-10-22 CA CA002269814A patent/CA2269814A1/en not_active Abandoned
- 1997-10-22 KR KR1019990703721A patent/KR20000052872A/ko not_active Application Discontinuation
- 1997-10-22 IL IL12941897A patent/IL129418A0/xx unknown
- 1997-10-22 EE EEP199900182A patent/EE9900182A/xx unknown
- 1997-10-22 US US09/284,313 patent/US6103724A/en not_active Expired - Fee Related
- 1997-10-22 AP APAP/P/1999/001532A patent/AP9901532A0/en unknown
- 1997-10-22 AU AU49620/97A patent/AU4962097A/en not_active Abandoned
- 1997-10-22 EA EA199900433A patent/EA199900433A1/ru unknown
- 1997-10-22 EP EP97912393A patent/EP0935599A1/en not_active Withdrawn
- 1997-10-22 WO PCT/HU1997/000069 patent/WO1998018797A1/en not_active Application Discontinuation
- 1997-10-22 BR BR9712588-1A patent/BR9712588A/pt not_active Application Discontinuation
- 1997-10-22 PL PL97333076A patent/PL333076A1/xx unknown
- 1997-10-22 CZ CZ991320A patent/CZ132099A3/cs unknown
- 1997-10-22 JP JP10520214A patent/JP2001503048A/ja active Pending
- 1997-10-22 TR TR1999/00946T patent/TR199900946T2/xx unknown
- 1997-10-27 ZA ZA9709617A patent/ZA979617B/xx unknown
- 1997-10-31 AR ARP970105061A patent/AR010260A1/es unknown
- 1997-11-17 TW TW086117150A patent/TW406083B/zh active
-
1999
- 1999-04-15 IS IS5026A patent/IS5026A/is unknown
- 1999-04-29 BG BG103370A patent/BG103370A/bg unknown
- 1999-04-29 NO NO992059A patent/NO992059D0/no not_active Application Discontinuation
- 1999-04-30 OA OA9900092A patent/OA11041A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| OA11041A (en) | 2003-03-07 |
| NO992059L (no) | 1999-04-29 |
| TW406083B (en) | 2000-09-21 |
| JP2001503048A (ja) | 2001-03-06 |
| KR20000052872A (ko) | 2000-08-25 |
| PL333076A1 (en) | 1999-11-08 |
| HU9603001D0 (en) | 1996-12-30 |
| BR9712588A (pt) | 1999-10-26 |
| SK49499A3 (en) | 2000-03-13 |
| TR199900946T2 (xx) | 1999-07-21 |
| HUP9603001A2 (hu) | 1998-07-28 |
| BG103370A (bg) | 2000-05-31 |
| IL129418A0 (en) | 2000-02-17 |
| IS5026A (is) | 1999-04-15 |
| CN1235606A (zh) | 1999-11-17 |
| AP9901532A0 (en) | 1999-06-30 |
| NO992059D0 (no) | 1999-04-29 |
| US6103724A (en) | 2000-08-15 |
| EA199900433A1 (ru) | 1999-10-28 |
| EE9900182A (et) | 1999-12-15 |
| CZ132099A3 (cs) | 1999-08-11 |
| ZA979617B (en) | 1998-05-21 |
| AU4962097A (en) | 1998-05-22 |
| HUP9603001A3 (en) | 1999-07-28 |
| EP0935599A1 (en) | 1999-08-18 |
| CA2269814A1 (en) | 1998-05-07 |
| WO1998018797A1 (en) | 1998-05-07 |
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