BR9712588A - Derivados de 2-metoxilfenilpiperazina - Google Patents

Derivados de 2-metoxilfenilpiperazina

Info

Publication number
BR9712588A
BR9712588A BR9712588-1A BR9712588A BR9712588A BR 9712588 A BR9712588 A BR 9712588A BR 9712588 A BR9712588 A BR 9712588A BR 9712588 A BR9712588 A BR 9712588A
Authority
BR
Brazil
Prior art keywords
compounds
imidazo
relates
derivatives
formula
Prior art date
Application number
BR9712588-1A
Other languages
English (en)
Inventor
Istvan Laslovszky
Erzsebet Lapis
Ferenc Trischler
Gyorgy Domany
Bela Hegedues
Tibor Acs
Gyorgy Ferenczy
Ferenc Auth
Monika Csejtei
Csaba Szantay Jr
Eszter Thuroczyne Kalman
Egon Karpati
Bela Kiss
Judit Laszy
Margit Pellioniszne Paroczai
Adam Sarkadi
Sandor Azabo
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of BR9712588A publication Critical patent/BR9712588A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

<B>DERIVADOS DE 2-METOXIFENILPIRERAZINA<D>. A invenção refere-se a compostos heterocíclicos fundidos, novos com átomo de nitrogênio de junção de anel da fórmula (I), em que Q representa grupo de 2-indolizinila, 2-imidazo [1,2-a]piridinila, 2-imidazo [1,2-a]-piramidi-nila, 6- (2, 3-diidroimidazo [2, 1-b] tiazol -ila ou 6-imidazo [2,1-b] -tiazolila; e n é um número inteiro de 2 a 4, bem como seus sais terapeuticamente úteis. A invenção refere-se ainda a composições farmacêuticas contendo estes compostos em como a um processo para a preparação dos compostos e composições acima. Os compostos novos da fórmula (I) apresenta efeitos antipsicóticos de modo que a invenção se refere também a um método de tratamento de esquizofrenia, distúrbios mentais, distúrbios afetivos, ansiedade e distúrbios de personalidade.
BR9712588-1A 1996-10-30 1997-10-22 Derivados de 2-metoxilfenilpiperazina BR9712588A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9603001A HUP9603001A3 (en) 1996-10-30 1996-10-30 Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
PCT/HU1997/000069 WO1998018797A1 (en) 1996-10-30 1997-10-22 2-methoxyphenylpiperazine derivatives

Publications (1)

Publication Number Publication Date
BR9712588A true BR9712588A (pt) 1999-10-26

Family

ID=89994394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712588-1A BR9712588A (pt) 1996-10-30 1997-10-22 Derivados de 2-metoxilfenilpiperazina

Country Status (25)

Country Link
US (1) US6103724A (pt)
EP (1) EP0935599A1 (pt)
JP (1) JP2001503048A (pt)
KR (1) KR20000052872A (pt)
CN (1) CN1235606A (pt)
AP (1) AP9901532A0 (pt)
AR (1) AR010260A1 (pt)
AU (1) AU4962097A (pt)
BG (1) BG103370A (pt)
BR (1) BR9712588A (pt)
CA (1) CA2269814A1 (pt)
CZ (1) CZ132099A3 (pt)
EA (1) EA199900433A1 (pt)
EE (1) EE9900182A (pt)
HU (1) HUP9603001A3 (pt)
IL (1) IL129418A0 (pt)
IS (1) IS5026A (pt)
NO (1) NO992059D0 (pt)
OA (1) OA11041A (pt)
PL (1) PL333076A1 (pt)
SK (1) SK49499A3 (pt)
TR (1) TR199900946T2 (pt)
TW (1) TW406083B (pt)
WO (1) WO1998018797A1 (pt)
ZA (1) ZA979617B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2383327C (en) * 1999-09-14 2009-11-03 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
SK3512002A3 (en) * 1999-09-14 2003-03-04 Aventis Pharma Inc Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
EP1268478B1 (en) 2000-03-31 2007-05-02 Ortho-McNeil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
KR20100091965A (ko) * 2007-10-24 2010-08-19 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
CA2704027A1 (en) * 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
US7985752B2 (en) 2008-05-29 2011-07-26 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof
US7964605B2 (en) 2008-05-29 2011-06-21 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof
CN106187873B (zh) * 2016-07-25 2019-11-05 宜春学院 一种芳胺基烷基氧类化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880824A (en) * 1987-09-21 1989-11-14 Ortho Pharmaceutical Corporation Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers
US5688949A (en) * 1991-04-22 1997-11-18 Otsuka Pharmaceutical Factory, Inc. Pyrazolo 1,5-A!pyrimidine derivatives and anti-inflammatory agent containing the same
US5486517A (en) * 1994-05-10 1996-01-23 Warner-Lambert Company Benzimidazoles and imidazopyridines as central nervous system agents
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases

Also Published As

Publication number Publication date
OA11041A (en) 2003-03-07
NO992059L (no) 1999-04-29
TW406083B (en) 2000-09-21
JP2001503048A (ja) 2001-03-06
KR20000052872A (ko) 2000-08-25
PL333076A1 (en) 1999-11-08
HU9603001D0 (en) 1996-12-30
AR010260A1 (es) 2000-06-07
SK49499A3 (en) 2000-03-13
TR199900946T2 (xx) 1999-07-21
HUP9603001A2 (hu) 1998-07-28
BG103370A (bg) 2000-05-31
IL129418A0 (en) 2000-02-17
IS5026A (is) 1999-04-15
CN1235606A (zh) 1999-11-17
AP9901532A0 (en) 1999-06-30
NO992059D0 (no) 1999-04-29
US6103724A (en) 2000-08-15
EA199900433A1 (ru) 1999-10-28
EE9900182A (et) 1999-12-15
CZ132099A3 (cs) 1999-08-11
ZA979617B (en) 1998-05-21
AU4962097A (en) 1998-05-22
HUP9603001A3 (en) 1999-07-28
EP0935599A1 (en) 1999-08-18
CA2269814A1 (en) 1998-05-07
WO1998018797A1 (en) 1998-05-07

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]