AR006310A1 - Un inhibidor de la serina proteasa, una composicion farmaceutica que comprende dicho inhibidor y usos de dicho inhibidor - Google Patents
Un inhibidor de la serina proteasa, una composicion farmaceutica que comprende dicho inhibidor y usos de dicho inhibidorInfo
- Publication number
- AR006310A1 AR006310A1 ARP970100833A ARP970100833A AR006310A1 AR 006310 A1 AR006310 A1 AR 006310A1 AR P970100833 A ARP970100833 A AR P970100833A AR P970100833 A ARP970100833 A AR P970100833A AR 006310 A1 AR006310 A1 AR 006310A1
- Authority
- AR
- Argentina
- Prior art keywords
- chr2
- amino acid
- inhibitor
- r2ooc
- optionally substituted
- Prior art date
Links
- 229940122055 Serine protease inhibitor Drugs 0.000 title abstract 2
- 101710102218 Serine protease inhibitor Proteins 0.000 title abstract 2
- 239000003001 serine protease inhibitor Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 alpha-hydroxyacetyl Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 230000002209 hydrophobic effect Effects 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200543 | 1996-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006310A1 true AR006310A1 (es) | 1999-08-25 |
Family
ID=8223736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100833A AR006310A1 (es) | 1996-03-01 | 1997-03-03 | Un inhibidor de la serina proteasa, una composicion farmaceutica que comprende dicho inhibidor y usos de dicho inhibidor |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6410684B1 (https=) |
| EP (1) | EP0886647B1 (https=) |
| JP (1) | JP2000506837A (https=) |
| KR (1) | KR19990087415A (https=) |
| CN (1) | CN1212704A (https=) |
| AR (1) | AR006310A1 (https=) |
| AT (1) | ATE221080T1 (https=) |
| AU (1) | AU709330B2 (https=) |
| BR (1) | BR9707808A (https=) |
| CA (1) | CA2246246A1 (https=) |
| CZ (1) | CZ277898A3 (https=) |
| DE (1) | DE69714222T2 (https=) |
| DK (1) | DK0886647T3 (https=) |
| ES (1) | ES2180933T3 (https=) |
| HU (1) | HUP9900390A3 (https=) |
| IL (1) | IL120310A (https=) |
| NO (1) | NO983991L (https=) |
| NZ (1) | NZ331484A (https=) |
| PL (1) | PL328875A1 (https=) |
| PT (1) | PT886647E (https=) |
| RU (1) | RU2178419C2 (https=) |
| TR (1) | TR199801704T2 (https=) |
| TW (1) | TW442452B (https=) |
| WO (1) | WO1997031937A1 (https=) |
| ZA (1) | ZA971667B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ291690B6 (cs) * | 1996-02-13 | 2003-05-14 | Akzo Nobel N. V. | Inhibitory serinové proteázy a farmaceutický prostředek |
| JP2001525823A (ja) | 1997-05-15 | 2001-12-11 | イーライ・リリー・アンド・カンパニー | 抗血栓化合物 |
| CA2326763A1 (en) | 1998-04-30 | 1999-11-11 | Theodore O. Johnson, Jr. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and methods for their synthesis |
| WO2000009542A1 (en) * | 1998-08-17 | 2000-02-24 | Cortech, Inc. | SERINE PROTEASE INHIBITORS COMPRISING α-KETO HETEROCYCLES |
| AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| US6849605B1 (en) | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| EP1206484B1 (en) * | 1999-08-04 | 2004-10-06 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| US6632825B2 (en) | 2000-06-14 | 2003-10-14 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| KR20030081297A (ko) | 2000-07-21 | 2003-10-17 | 쉐링 코포레이션 | Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제억제제로서의 신규한 펩티드 |
| DK1385870T3 (da) | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
| JP2004518688A (ja) | 2001-01-30 | 2004-06-24 | ブリストル−マイヤーズ スクイブ カンパニー | ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法 |
| US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
| DE602005023965D1 (de) | 2004-03-08 | 2010-11-18 | Prosidion Ltd | Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase |
| ATE424821T1 (de) | 2004-12-02 | 2009-03-15 | Prosidion Ltd | Pyrrolopyridin-2-karbonsäureamide |
| BRPI0823193A2 (pt) * | 2008-10-15 | 2019-09-24 | Danisco Us Inc | inibidores de protease de bowman birk variantes modificados |
| US10526315B2 (en) | 2016-06-21 | 2020-01-07 | Orion Ophthalmology LLC | Carbocyclic prolinamide derivatives |
| PL3472149T3 (pl) | 2016-06-21 | 2024-02-12 | Orion Ophthalmology LLC | Heterocykliczne pochodne prolinamidu |
| JP2023533016A (ja) | 2020-07-11 | 2023-08-01 | ファイザー・インク | 抗ウイルス性ヘテロアリールケトン誘導体 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556655A (en) * | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
| CA2008116C (en) * | 1989-02-23 | 2001-11-20 | Thomas Weller | Glycine derivatives |
| ZW11290A1 (en) * | 1989-07-14 | 1990-10-31 | Smithkline Beecham Corp | Hemoregulatory peptides |
| US5672582A (en) * | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2159834A1 (en) * | 1993-04-30 | 1994-11-10 | Daniel F. Veber | Thrombin inhibitors |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| ZA951618B (en) | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| WO1995035311A1 (en) * | 1994-06-17 | 1995-12-28 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors |
| JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
| WO1996019483A1 (en) * | 1994-12-22 | 1996-06-27 | Biochem Pharma Inc. | Low molecular weight bicyclic thrombin inhibitors |
-
1997
- 1997-02-25 IL IL12031097A patent/IL120310A/en not_active IP Right Cessation
- 1997-02-25 TW TW086102261A patent/TW442452B/zh not_active IP Right Cessation
- 1997-02-26 BR BR9707808A patent/BR9707808A/pt not_active Application Discontinuation
- 1997-02-26 TR TR1998/01704T patent/TR199801704T2/xx unknown
- 1997-02-26 EP EP97905099A patent/EP0886647B1/en not_active Expired - Lifetime
- 1997-02-26 AU AU18775/97A patent/AU709330B2/en not_active Ceased
- 1997-02-26 RU RU98117949/04A patent/RU2178419C2/ru active
- 1997-02-26 DK DK97905099T patent/DK0886647T3/da active
- 1997-02-26 CA CA002246246A patent/CA2246246A1/en not_active Abandoned
- 1997-02-26 ZA ZA9701667A patent/ZA971667B/xx unknown
- 1997-02-26 HU HU9900390A patent/HUP9900390A3/hu unknown
- 1997-02-26 CN CN97192682A patent/CN1212704A/zh active Pending
- 1997-02-26 WO PCT/EP1997/000938 patent/WO1997031937A1/en not_active Ceased
- 1997-02-26 AT AT97905099T patent/ATE221080T1/de not_active IP Right Cessation
- 1997-02-26 US US09/142,110 patent/US6410684B1/en not_active Expired - Fee Related
- 1997-02-26 PT PT97905099T patent/PT886647E/pt unknown
- 1997-02-26 ES ES97905099T patent/ES2180933T3/es not_active Expired - Lifetime
- 1997-02-26 DE DE69714222T patent/DE69714222T2/de not_active Expired - Fee Related
- 1997-02-26 JP JP9530600A patent/JP2000506837A/ja not_active Ceased
- 1997-02-26 PL PL97328875A patent/PL328875A1/xx unknown
- 1997-02-26 KR KR1019980706833A patent/KR19990087415A/ko not_active Ceased
- 1997-02-26 NZ NZ331484A patent/NZ331484A/xx unknown
- 1997-02-26 CZ CZ982778A patent/CZ277898A3/cs unknown
- 1997-03-03 AR ARP970100833A patent/AR006310A1/es unknown
-
1998
- 1998-08-31 NO NO983991A patent/NO983991L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW442452B (en) | 2001-06-23 |
| HK1021541A1 (en) | 2000-06-16 |
| WO1997031937A1 (en) | 1997-09-04 |
| HUP9900390A2 (hu) | 1999-06-28 |
| ATE221080T1 (de) | 2002-08-15 |
| RU2178419C2 (ru) | 2002-01-20 |
| PL328875A1 (en) | 1999-03-01 |
| NZ331484A (en) | 2000-01-28 |
| ZA971667B (en) | 1997-09-10 |
| IL120310A0 (en) | 1997-06-10 |
| DE69714222D1 (de) | 2002-08-29 |
| KR19990087415A (ko) | 1999-12-27 |
| NO983991D0 (no) | 1998-08-31 |
| HUP9900390A3 (en) | 2000-11-28 |
| PT886647E (pt) | 2002-12-31 |
| AU709330B2 (en) | 1999-08-26 |
| DK0886647T3 (da) | 2002-11-04 |
| CA2246246A1 (en) | 1997-09-04 |
| CZ277898A3 (cs) | 1999-06-16 |
| US6410684B1 (en) | 2002-06-25 |
| AU1877597A (en) | 1997-09-16 |
| TR199801704T2 (xx) | 1998-12-21 |
| IL120310A (en) | 2002-02-10 |
| DE69714222T2 (de) | 2003-02-20 |
| CN1212704A (zh) | 1999-03-31 |
| EP0886647A1 (en) | 1998-12-30 |
| JP2000506837A (ja) | 2000-06-06 |
| NO983991L (no) | 1998-10-30 |
| EP0886647B1 (en) | 2002-07-24 |
| BR9707808A (pt) | 1999-07-27 |
| ES2180933T3 (es) | 2003-02-16 |
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