AP823A - Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. - Google Patents
Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. Download PDFInfo
- Publication number
- AP823A AP823A APAP/P/1998/001351A AP9801351A AP823A AP 823 A AP823 A AP 823A AP 9801351 A AP9801351 A AP 9801351A AP 823 A AP823 A AP 823A
- Authority
- AP
- ARIPO
- Prior art keywords
- formula
- alkyl
- compound
- compounds
- groups include
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9606508.1A GB9606508D0 (en) | 1996-03-28 | 1996-03-28 | Chemical componds |
GBGB9623001.6A GB9623001D0 (en) | 1996-11-05 | 1996-11-05 | Chemical compounds |
PCT/EP1997/001530 WO1997036903A1 (en) | 1996-03-28 | 1997-03-26 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
Publications (2)
Publication Number | Publication Date |
---|---|
AP9801351A0 AP9801351A0 (en) | 1998-09-30 |
AP823A true AP823A (en) | 2000-04-25 |
Family
ID=26309008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1998/001351A AP823A (en) | 1996-03-28 | 1997-03-26 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. |
Country Status (30)
Country | Link |
---|---|
US (3) | US5994344A (sk) |
EP (1) | EP0891362B1 (sk) |
JP (1) | JP4118337B2 (sk) |
KR (1) | KR20000005039A (sk) |
CN (1) | CN1067075C (sk) |
AP (1) | AP823A (sk) |
AR (1) | AR006401A1 (sk) |
AT (1) | ATE261969T1 (sk) |
AU (1) | AU726649B2 (sk) |
BR (1) | BR9708449A (sk) |
CA (1) | CA2250209A1 (sk) |
CO (1) | CO4790152A1 (sk) |
CZ (1) | CZ309798A3 (sk) |
DE (1) | DE69728139T2 (sk) |
DK (1) | DK0891362T3 (sk) |
EA (1) | EA001437B1 (sk) |
EE (1) | EE9800335A (sk) |
ES (1) | ES2217404T3 (sk) |
HU (1) | HUP9900567A3 (sk) |
IL (1) | IL125859A0 (sk) |
IS (1) | IS4837A (sk) |
NO (1) | NO984470L (sk) |
NZ (1) | NZ331490A (sk) |
PE (1) | PE55298A1 (sk) |
PL (1) | PL329153A1 (sk) |
PT (1) | PT891362E (sk) |
SK (1) | SK132498A3 (sk) |
TR (1) | TR199801935T2 (sk) |
WO (1) | WO1997036903A1 (sk) |
YU (1) | YU41198A (sk) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9719189D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
GB9719187D0 (en) | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
GB9719172D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
PE107899A1 (es) * | 1997-09-09 | 1999-11-17 | Glaxo Group Ltd | Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria |
GB9821199D0 (en) * | 1998-09-30 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
GB9905418D0 (en) * | 1999-03-09 | 1999-05-05 | Glaxo Group Ltd | Process |
AU2003216707A1 (en) * | 2003-03-10 | 2004-09-30 | Hetero Drugs Limited | Amorphous clopidogrel hydrogen sulfate |
MXPA05009771A (es) | 2003-03-14 | 2005-10-26 | Ono Pharmaceutical Co | Derivados heterociclicos que contienen nitrogeno y medicamentos que los contienen como el ingrediente activo. |
US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
US7692037B2 (en) * | 2004-09-02 | 2010-04-06 | Eastman Chemical Company | Optimized liquid-phase oxidation |
TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
GB0512238D0 (en) * | 2005-06-15 | 2005-07-27 | Univ Cambridge Tech | Anti-inflammatory agents |
US8003642B2 (en) | 2006-03-10 | 2011-08-23 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
CN101702904A (zh) * | 2007-04-23 | 2010-05-05 | 西佳技术公司 | 用于治疗和预防正痘病毒感染和相关疾病的化合物、组合物和方法 |
US8119809B2 (en) | 2007-11-16 | 2012-02-21 | Rigel Pharmaceuticals, Inc. | AMPK-activating heterocycloalkyloxy(hetero)aryl carboxamide, sulfonamide and amine compounds and methods for using the same |
ES2553340T3 (es) | 2007-12-12 | 2015-12-07 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
NZ588652A (en) | 2008-04-23 | 2012-09-28 | Rigel Pharmaceuticals Inc | Carboxamide compounds for the treatment of metabolic disorders |
SI2935274T1 (sl) * | 2012-12-18 | 2018-12-31 | Chiesi Farmaceutici S.P.A. | 3-okso-2,3,5,8-tetrahidro-(1,2,4)triazolo(4,3-a)pirimidinski derivati za zdravljenje bolezni dihal |
BR112022004861A2 (pt) | 2019-09-17 | 2022-06-07 | Univ Duke | Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro |
EP4106757B1 (en) | 2020-04-16 | 2023-08-23 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
EP4419102A1 (en) | 2021-10-20 | 2024-08-28 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993024519A1 (en) * | 1992-06-04 | 1993-12-09 | Zeneca Limited | Lactam dipeptides having hle inhibiting activity |
WO1995021855A1 (en) * | 1994-02-11 | 1995-08-17 | Zeneca Limited | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2932650A (en) * | 1957-11-19 | 1960-04-12 | Arthur C Cope | 2-6-diazabicyclo (3. 3. 0) octanes |
US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
US5610296A (en) * | 1994-12-05 | 1997-03-11 | G. D. Searle & Co. | Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs |
-
1997
- 1997-03-26 IL IL12585997A patent/IL125859A0/xx unknown
- 1997-03-26 KR KR1019980707664A patent/KR20000005039A/ko not_active Application Discontinuation
- 1997-03-26 TR TR1998/01935T patent/TR199801935T2/xx unknown
- 1997-03-26 PT PT97915439T patent/PT891362E/pt unknown
- 1997-03-26 BR BR9708449A patent/BR9708449A/pt unknown
- 1997-03-26 CN CN97194959A patent/CN1067075C/zh not_active Expired - Lifetime
- 1997-03-26 HU HU9900567A patent/HUP9900567A3/hu unknown
- 1997-03-26 EE EE9800335A patent/EE9800335A/xx unknown
- 1997-03-26 DE DE69728139T patent/DE69728139T2/de not_active Expired - Fee Related
- 1997-03-26 AT AT97915439T patent/ATE261969T1/de not_active IP Right Cessation
- 1997-03-26 AP APAP/P/1998/001351A patent/AP823A/en active
- 1997-03-26 SK SK1324-98A patent/SK132498A3/sk unknown
- 1997-03-26 EP EP97915439A patent/EP0891362B1/en not_active Expired - Lifetime
- 1997-03-26 PL PL97329153A patent/PL329153A1/xx unknown
- 1997-03-26 CA CA002250209A patent/CA2250209A1/en not_active Abandoned
- 1997-03-26 ES ES97915439T patent/ES2217404T3/es not_active Expired - Lifetime
- 1997-03-26 PE PE1997000244A patent/PE55298A1/es not_active Application Discontinuation
- 1997-03-26 JP JP53490797A patent/JP4118337B2/ja not_active Expired - Fee Related
- 1997-03-26 US US09/155,323 patent/US5994344A/en not_active Expired - Fee Related
- 1997-03-26 EA EA199800773A patent/EA001437B1/ru not_active IP Right Cessation
- 1997-03-26 NZ NZ331490A patent/NZ331490A/en unknown
- 1997-03-26 WO PCT/EP1997/001530 patent/WO1997036903A1/en active IP Right Grant
- 1997-03-26 AR ARP970101212A patent/AR006401A1/es not_active Application Discontinuation
- 1997-03-26 DK DK97915439T patent/DK0891362T3/da active
- 1997-03-26 CZ CZ983097A patent/CZ309798A3/cs unknown
- 1997-03-26 AU AU22917/97A patent/AU726649B2/en not_active Ceased
- 1997-03-31 CO CO97015902A patent/CO4790152A1/es unknown
-
1998
- 1998-08-28 IS IS4837A patent/IS4837A/is unknown
- 1998-09-23 YU YU41198A patent/YU41198A/sh unknown
- 1998-09-25 NO NO984470A patent/NO984470L/no not_active Application Discontinuation
-
1999
- 1999-10-15 US US09/418,644 patent/US6057457A/en not_active Expired - Fee Related
-
2000
- 2000-03-03 US US09/517,963 patent/US6215002B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993024519A1 (en) * | 1992-06-04 | 1993-12-09 | Zeneca Limited | Lactam dipeptides having hle inhibiting activity |
WO1995021855A1 (en) * | 1994-02-11 | 1995-08-17 | Zeneca Limited | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase |
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