AP306A - Water soluble camptothecin derivatives. - Google Patents
Water soluble camptothecin derivatives. Download PDFInfo
- Publication number
- AP306A AP306A APAP/P/1992/000439A AP9200439A AP306A AP 306 A AP306 A AP 306A AP 9200439 A AP9200439 A AP 9200439A AP 306 A AP306 A AP 306A
- Authority
- AP
- ARIPO
- Prior art keywords
- compound
- lower alkyl
- camptothecin
- formula
- ethylenedioxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78427591A | 1991-10-29 | 1991-10-29 | |
US82672992A | 1992-01-28 | 1992-01-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
AP9200439A0 AP9200439A0 (en) | 1992-10-31 |
AP306A true AP306A (en) | 1994-01-28 |
Family
ID=27120258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1992/000439A AP306A (en) | 1991-10-29 | 1992-10-28 | Water soluble camptothecin derivatives. |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0540099B1 (de) |
JP (2) | JP3020760B2 (de) |
KR (1) | KR100246154B1 (de) |
CN (1) | CN1072683A (de) |
AP (1) | AP306A (de) |
AT (1) | ATE136898T1 (de) |
AU (1) | AU657007B2 (de) |
CA (1) | CA2081580A1 (de) |
CZ (1) | CZ284023B6 (de) |
DE (1) | DE69209969T2 (de) |
DK (1) | DK0540099T3 (de) |
ES (1) | ES2086643T3 (de) |
FI (3) | FI104373B (de) |
GR (1) | GR3020120T3 (de) |
HU (2) | HU217970B (de) |
IL (1) | IL103571A (de) |
IS (1) | IS1708B (de) |
MX (1) | MX9206211A (de) |
MY (1) | MY108261A (de) |
NO (1) | NO302073B1 (de) |
NZ (1) | NZ244914A (de) |
OA (1) | OA09767A (de) |
RU (1) | RU2119921C1 (de) |
SK (1) | SK279298B6 (de) |
TW (1) | TW221994B (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
ATE388706T1 (de) * | 1993-01-15 | 2008-03-15 | Stehlin Foundation For Cancer | Die verwendung von wasserunlöslichem s- camptothecin mit geschlossenem lactonring für die herstellung eines medikamentes zur behandlung von darmkrebs |
US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
IS4152A (is) * | 1993-04-29 | 1994-10-30 | Glaxo Inc. | Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra |
JPH08509742A (ja) * | 1993-05-03 | 1996-10-15 | スミスクライン・ビーチャム・コーポレイション | 置換メチレンジオキシ[3’,4’:6,7]インドリジノ[1,2−b]キノリノン |
US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
US5491237A (en) | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
KR960029336A (ko) | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
US5496952A (en) * | 1995-02-07 | 1996-03-05 | North Carolina State University | Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs |
US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
US5708005A (en) * | 1995-06-27 | 1998-01-13 | Takeda Chemical Industries, Ltd. | Quinolines, their production and use |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
AU7732996A (en) * | 1995-11-22 | 1997-06-11 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
SG88737A1 (en) * | 1996-10-30 | 2002-05-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
BR0108728A (pt) | 2000-02-28 | 2003-12-30 | Aventis Pharma Sa | Combinação farmacêutica terapêutica, e, método para tratar um c ncer. |
US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
WO2002034244A2 (en) | 2000-10-27 | 2002-05-02 | Aventis Pharma S.A. | A combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
US20090104254A1 (en) | 2004-12-22 | 2009-04-23 | Rutgers, The State University Of New Jersey | Controlled Release Hydrogels |
AU2007232206B2 (en) | 2006-03-30 | 2013-04-04 | Drais Pharmaceuticals, Inc. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
CN101407524B (zh) * | 2007-10-09 | 2012-07-18 | 江苏先声药物研究有限公司 | 噁嗪骈喜树碱衍生物及其制备方法和用途 |
CN100592871C (zh) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | 一种杀虫剂组合物及其加工方法 |
ES2373172B1 (es) * | 2010-07-16 | 2012-12-10 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales. |
US8980909B2 (en) | 2011-01-12 | 2015-03-17 | Crystal Biopharmaceutical Llc | HDAC inhibiting derivatives of camptothecin |
JP7430643B2 (ja) * | 2018-04-06 | 2024-02-13 | シージェン インコーポレイテッド | カンプトテシンペプチドコンジュゲート |
CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
CN117769555A (zh) * | 2021-08-19 | 2024-03-26 | 先声再明医药有限公司 | 喜树碱衍生物、其药物组合物及其应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
-
1992
- 1992-10-23 ES ES92203263T patent/ES2086643T3/es not_active Expired - Lifetime
- 1992-10-23 DE DE69209969T patent/DE69209969T2/de not_active Expired - Fee Related
- 1992-10-23 AT AT92203263T patent/ATE136898T1/de not_active IP Right Cessation
- 1992-10-23 EP EP92203263A patent/EP0540099B1/de not_active Expired - Lifetime
- 1992-10-23 DK DK92203263.6T patent/DK0540099T3/da active
- 1992-10-27 TW TW081108539A patent/TW221994B/zh active
- 1992-10-27 CZ CS923237A patent/CZ284023B6/cs not_active IP Right Cessation
- 1992-10-27 SK SK3237-92A patent/SK279298B6/sk unknown
- 1992-10-28 IS IS3936A patent/IS1708B/is unknown
- 1992-10-28 NZ NZ244914A patent/NZ244914A/xx not_active IP Right Cessation
- 1992-10-28 OA OA60295A patent/OA09767A/en unknown
- 1992-10-28 FI FI924878A patent/FI104373B/fi active
- 1992-10-28 RU RU92004336A patent/RU2119921C1/ru not_active IP Right Cessation
- 1992-10-28 NO NO924158A patent/NO302073B1/no unknown
- 1992-10-28 KR KR1019920019884A patent/KR100246154B1/ko not_active IP Right Cessation
- 1992-10-28 AU AU27385/92A patent/AU657007B2/en not_active Ceased
- 1992-10-28 MY MYPI92001954A patent/MY108261A/en unknown
- 1992-10-28 JP JP4312862A patent/JP3020760B2/ja not_active Expired - Fee Related
- 1992-10-28 HU HU9203384A patent/HU217970B/hu not_active IP Right Cessation
- 1992-10-28 MX MX9206211A patent/MX9206211A/es unknown
- 1992-10-28 CN CN92113782A patent/CN1072683A/zh not_active Withdrawn
- 1992-10-28 CA CA002081580A patent/CA2081580A1/en not_active Abandoned
- 1992-10-28 IL IL103571A patent/IL103571A/en not_active IP Right Cessation
- 1992-10-28 AP APAP/P/1992/000439A patent/AP306A/en active
-
1995
- 1995-06-14 HU HU95P/P00203P patent/HU211349A9/hu unknown
-
1996
- 1996-05-31 GR GR960401497T patent/GR3020120T3/el unknown
-
1998
- 1998-10-08 FI FI982185A patent/FI982185A/fi unknown
-
1999
- 1999-11-02 JP JP31294099A patent/JP3229298B2/ja not_active Expired - Fee Related
-
2002
- 2002-06-07 FI FI20021090A patent/FI20021090A/fi not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
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