AP262A - Novel antiviral tetrahydroimidazo (1,4) benzodiazepin-2-(thi) ones. - Google Patents

Novel antiviral tetrahydroimidazo (1,4) benzodiazepin-2-(thi) ones. Download PDF

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Publication number
AP262A
AP262A APAP/P/1991/000289A AP9100289A AP262A AP 262 A AP262 A AP 262A AP 9100289 A AP9100289 A AP 9100289A AP 262 A AP262 A AP 262A
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AP
ARIPO
Prior art keywords
formula
hydrogen
reaction
parts
compound
Prior art date
Application number
APAP/P/1991/000289A
Other languages
English (en)
Other versions
AP9100289A0 (en
Inventor
Michael Joseph Kukla
Henry Joseph Breslin
Alfons Herman Margaretha Raeymaekers
GELDER Josephus Ludovicus Huberstus VAN
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP9100289A0 publication Critical patent/AP9100289A0/xx
Application granted granted Critical
Publication of AP262A publication Critical patent/AP262A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1991/000289A 1990-07-06 1991-07-05 Novel antiviral tetrahydroimidazo (1,4) benzodiazepin-2-(thi) ones. AP262A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54934990A 1990-07-06 1990-07-06

Publications (2)

Publication Number Publication Date
AP9100289A0 AP9100289A0 (en) 1991-07-31
AP262A true AP262A (en) 1993-06-03

Family

ID=24192641

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000289A AP262A (en) 1990-07-06 1991-07-05 Novel antiviral tetrahydroimidazo (1,4) benzodiazepin-2-(thi) ones.

Country Status (29)

Country Link
EP (1) EP0538297B9 (fr)
JP (1) JPH05508632A (fr)
CN (1) CN1034122C (fr)
AP (1) AP262A (fr)
AT (1) ATE205848T1 (fr)
AU (1) AU644192B2 (fr)
CA (1) CA2086547A1 (fr)
CZ (1) CZ279900B6 (fr)
DE (1) DE69132738T2 (fr)
DK (1) DK0538297T3 (fr)
ES (1) ES2164044T3 (fr)
FI (1) FI930024A0 (fr)
HU (1) HUT68382A (fr)
IE (1) IE912363A1 (fr)
IL (1) IL98726A (fr)
MA (1) MA22205A1 (fr)
MX (1) MX9100103A (fr)
MY (1) MY106786A (fr)
NO (1) NO300420B1 (fr)
NZ (1) NZ238664A (fr)
OA (1) OA09769A (fr)
PL (3) PL169613B1 (fr)
PT (1) PT98225B (fr)
SK (1) SK278442B6 (fr)
TN (1) TNSN91055A1 (fr)
TW (1) TW211014B (fr)
WO (1) WO1992000979A1 (fr)
YU (1) YU48176B (fr)
ZA (1) ZA915239B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
WO1993023021A2 (fr) * 1992-05-13 1993-11-25 The Wellcome Foundation Limited Combinaisons therapeutiques
US5663169A (en) * 1992-08-07 1997-09-02 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
US6420357B1 (en) 1997-12-23 2002-07-16 Instituto Biomar, S.A. Cytotoxic alkaloid derivatives including Asmarine A and B isolated from a sponge
KR20040100835A (ko) 2001-02-15 2004-12-02 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 안정된 제약및 갑상선 내분비 호르몬 구성물 및 그제조방법
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
RU2440120C1 (ru) * 2010-11-19 2012-01-20 Государственное Учебно-Научное Учреждение Химический Факультет Московского Государственного Университета Имени М.В. Ломоносова КОМПОЗИЦИЯ ДЛЯ ИНЪЕКЦИЙ НА ОСНОВЕ КРИСТАЛЛИЧЕСКОЙ β-МОДИФИКАЦИИ 7-БРОМ-1,3-ДИГИДРО-5-(2-ХЛОРФЕНИЛ)-2Н-1,4-БЕНЗОДИАЗЕПИН-2-ОНА, ОБЛАДАЮЩАЯ ТРАНКВИЛИЗИРУЮЩИМ ДЕЙСТВИЕМ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336466A1 (fr) * 1988-03-18 1989-10-11 Janssen Pharmaceutica N.V. Tetrahydroimidazo (1,4) benzodiazépin-2-ones antivirales

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them
NZ235137A (en) * 1989-09-13 1992-02-25 Janssen Pharmaceutica Nv Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof
DE4036552C1 (fr) * 1990-11-16 1992-02-06 Boehringer Mannheim Gmbh, 6800 Mannheim, De

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336466A1 (fr) * 1988-03-18 1989-10-11 Janssen Pharmaceutica N.V. Tetrahydroimidazo (1,4) benzodiazépin-2-ones antivirales

Also Published As

Publication number Publication date
NO924853D0 (no) 1992-12-15
PL169613B1 (pl) 1996-08-30
FI930024A7 (fi) 1993-01-05
AP9100289A0 (en) 1991-07-31
EP0538297B1 (fr) 2001-09-19
ES2164044T3 (es) 2002-02-16
PL169662B1 (en) 1996-08-30
CN1057840A (zh) 1992-01-15
NZ238664A (en) 1992-12-23
FI930024A0 (fi) 1993-01-05
MY106786A (en) 1995-07-31
CZ279900B6 (cs) 1995-08-16
DE69132738D1 (de) 2001-10-25
AU644192B2 (en) 1993-12-02
DE69132738T2 (de) 2002-07-04
IE912363A1 (en) 1992-01-15
IL98726A (en) 1996-01-31
EP0538297A1 (fr) 1993-04-28
CS206591A3 (en) 1992-03-18
YU119491A (sh) 1994-06-10
IL98726A0 (en) 1992-07-15
TW211014B (fr) 1993-08-11
DK0538297T3 (da) 2001-12-27
MX9100103A (es) 1992-02-28
JPH05508632A (ja) 1993-12-02
ATE205848T1 (de) 2001-10-15
PT98225A (pt) 1992-05-29
PL297379A1 (fr) 1992-07-13
NO300420B1 (no) 1997-05-26
PL168320B1 (pl) 1996-02-29
YU48176B (sh) 1997-07-31
WO1992000979A1 (fr) 1992-01-23
HU9300011D0 (en) 1993-04-28
TNSN91055A1 (fr) 1992-10-25
CN1034122C (zh) 1997-02-26
ZA915239B (en) 1993-03-31
OA09769A (fr) 1993-11-30
NO924853L (no) 1992-12-15
CA2086547A1 (fr) 1992-01-07
PT98225B (pt) 1998-12-31
AU8068391A (en) 1992-02-04
MA22205A1 (fr) 1992-04-01
SK278442B6 (en) 1997-05-07
EP0538297B9 (fr) 2002-10-16
HUT68382A (en) 1995-06-28

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