HUT68382A - Process for producing new antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)one derivatives and pharmaceutical preparations containing them - Google Patents

Process for producing new antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)one derivatives and pharmaceutical preparations containing them Download PDF

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Publication number
HUT68382A
HUT68382A HU9300011A HU1193A HUT68382A HU T68382 A HUT68382 A HU T68382A HU 9300011 A HU9300011 A HU 9300011A HU 1193 A HU1193 A HU 1193A HU T68382 A HUT68382 A HU T68382A
Authority
HU
Hungary
Prior art keywords
formula
alkyl
parts
reaction
hydrogen
Prior art date
Application number
HU9300011A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9300011D0 (en
Inventor
Alfons Herman Marg Raeymaekers
Michael Joseph Kukla
Josephus Ludovicus Hube Gelder
Henry Joseph Breslin
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HU9300011D0 publication Critical patent/HU9300011D0/hu
Publication of HUT68382A publication Critical patent/HUT68382A/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU9300011A 1990-07-06 1991-06-28 Process for producing new antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)one derivatives and pharmaceutical preparations containing them HUT68382A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54934990A 1990-07-06 1990-07-06

Publications (2)

Publication Number Publication Date
HU9300011D0 HU9300011D0 (en) 1993-04-28
HUT68382A true HUT68382A (en) 1995-06-28

Family

ID=24192641

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9300011A HUT68382A (en) 1990-07-06 1991-06-28 Process for producing new antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)one derivatives and pharmaceutical preparations containing them

Country Status (29)

Country Link
EP (1) EP0538297B9 (fr)
JP (1) JPH05508632A (fr)
CN (1) CN1034122C (fr)
AP (1) AP262A (fr)
AT (1) ATE205848T1 (fr)
AU (1) AU644192B2 (fr)
CA (1) CA2086547A1 (fr)
CZ (1) CZ279900B6 (fr)
DE (1) DE69132738T2 (fr)
DK (1) DK0538297T3 (fr)
ES (1) ES2164044T3 (fr)
FI (1) FI930024A (fr)
HU (1) HUT68382A (fr)
IE (1) IE912363A1 (fr)
IL (1) IL98726A (fr)
MA (1) MA22205A1 (fr)
MX (1) MX9100103A (fr)
MY (1) MY106786A (fr)
NO (1) NO300420B1 (fr)
NZ (1) NZ238664A (fr)
OA (1) OA09769A (fr)
PL (3) PL168320B1 (fr)
PT (1) PT98225B (fr)
SK (1) SK278442B6 (fr)
TN (1) TNSN91055A1 (fr)
TW (1) TW211014B (fr)
WO (1) WO1992000979A1 (fr)
YU (1) YU48176B (fr)
ZA (1) ZA915239B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
DK0639971T3 (da) * 1992-05-13 2000-03-20 Wellcome Found Terapeutiske kombinationer
US5519021A (en) * 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
US6420357B1 (en) 1997-12-23 2002-07-16 Instituto Biomar, S.A. Cytotoxic alkaloid derivatives including Asmarine A and B isolated from a sponge

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them
NZ235137A (en) * 1989-09-13 1992-02-25 Janssen Pharmaceutica Nv Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof
DE4036552C1 (fr) * 1990-11-16 1992-02-06 Boehringer Mannheim Gmbh, 6800 Mannheim, De

Also Published As

Publication number Publication date
FI930024A0 (fi) 1993-01-05
PL169613B1 (pl) 1996-08-30
CN1057840A (zh) 1992-01-15
AP9100289A0 (en) 1991-07-31
PL169662B1 (en) 1996-08-30
DE69132738T2 (de) 2002-07-04
IE912363A1 (en) 1992-01-15
FI930024A (fi) 1993-01-05
JPH05508632A (ja) 1993-12-02
PT98225B (pt) 1998-12-31
MA22205A1 (fr) 1992-04-01
AP262A (en) 1993-06-03
EP0538297B1 (fr) 2001-09-19
CS206591A3 (en) 1992-03-18
CZ279900B6 (cs) 1995-08-16
CA2086547A1 (fr) 1992-01-07
AU644192B2 (en) 1993-12-02
PL168320B1 (pl) 1996-02-29
YU48176B (sh) 1997-07-31
PL297379A1 (fr) 1992-07-13
SK278442B6 (en) 1997-05-07
IL98726A0 (en) 1992-07-15
ATE205848T1 (de) 2001-10-15
DK0538297T3 (da) 2001-12-27
DE69132738D1 (de) 2001-10-25
IL98726A (en) 1996-01-31
HU9300011D0 (en) 1993-04-28
NZ238664A (en) 1992-12-23
TNSN91055A1 (fr) 1992-10-25
CN1034122C (zh) 1997-02-26
TW211014B (fr) 1993-08-11
PT98225A (pt) 1992-05-29
AU8068391A (en) 1992-02-04
MX9100103A (es) 1992-02-28
NO924853L (no) 1992-12-15
YU119491A (sh) 1994-06-10
OA09769A (fr) 1993-11-30
ZA915239B (en) 1993-03-31
EP0538297A1 (fr) 1993-04-28
MY106786A (en) 1995-07-31
NO924853D0 (no) 1992-12-15
NO300420B1 (no) 1997-05-26
EP0538297B9 (fr) 2002-10-16
ES2164044T3 (es) 2002-02-16
WO1992000979A1 (fr) 1992-01-23

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HUT68382A (en) Process for producing new antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)one derivatives and pharmaceutical preparations containing them
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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary protection due to refusal