AP248A - Azole derivatives. - Google Patents

Azole derivatives. Download PDF

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Publication number
AP248A
AP248A APAP/P/1991/000266A AP9100266A AP248A AP 248 A AP248 A AP 248A AP 9100266 A AP9100266 A AP 9100266A AP 248 A AP248 A AP 248A
Authority
AP
ARIPO
Prior art keywords
furyl
amino
triazine
formula
alkyl
Prior art date
Application number
APAP/P/1991/000266A
Other languages
English (en)
Other versions
AP9100266A0 (en
Inventor
Peter William Rodney Caulkett
Geraint Jones
Michael George Collis
Simon Martin Poucher
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909011914A external-priority patent/GB9011914D0/en
Priority claimed from GB909011913A external-priority patent/GB9011913D0/en
Priority claimed from GB919101380A external-priority patent/GB9101380D0/en
Priority claimed from GB919101379A external-priority patent/GB9101379D0/en
Priority claimed from GB919104125A external-priority patent/GB9104125D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AP9100266A0 publication Critical patent/AP9100266A0/xx
Application granted granted Critical
Publication of AP248A publication Critical patent/AP248A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1991/000266A 1990-05-29 1991-05-28 Azole derivatives. AP248A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909011914A GB9011914D0 (en) 1990-05-29 1990-05-29 Heterocyclic compounds
GB909011913A GB9011913D0 (en) 1990-05-29 1990-05-29 Azole derivatives
GB919101380A GB9101380D0 (en) 1991-01-22 1991-01-22 Azole derivatives
GB919101379A GB9101379D0 (en) 1991-01-22 1991-01-22 Heterocyclic compounds
GB919104125A GB9104125D0 (en) 1991-02-27 1991-02-27 Azole derivatives

Publications (2)

Publication Number Publication Date
AP9100266A0 AP9100266A0 (en) 1991-07-31
AP248A true AP248A (en) 1993-03-16

Family

ID=27516979

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000266A AP248A (en) 1990-05-29 1991-05-28 Azole derivatives.

Country Status (20)

Country Link
US (1) US5270311A (ja)
EP (1) EP0459702A1 (ja)
JP (1) JP2504879B2 (ja)
KR (1) KR910020012A (ja)
CN (1) CN1056879A (ja)
AP (1) AP248A (ja)
AU (1) AU642494B2 (ja)
CA (1) CA2043424A1 (ja)
CS (1) CS159591A3 (ja)
FI (1) FI912563A (ja)
GB (1) GB2244487B (ja)
HU (1) HUT61311A (ja)
IE (1) IE911818A1 (ja)
IL (1) IL98316A (ja)
NO (1) NO178401C (ja)
NZ (1) NZ238288A (ja)
OA (1) OA09358A (ja)
PT (1) PT97776A (ja)
RO (1) RO109542B1 (ja)
YU (1) YU47812B (ja)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives
GB9226735D0 (en) * 1992-12-22 1993-02-17 Ici Plc Azole derivatives
US5356894A (en) * 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9125001D0 (en) * 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
GB9124968D0 (en) * 1991-11-25 1992-01-22 Ici Plc Chemical process
CA2144330A1 (en) * 1993-07-27 1995-02-09 Fumio Suzuki A therapeutic agent for parkinson's disease
CA2148502A1 (en) * 1993-09-06 1995-03-16 Fumio Suzuki Antidepressants
ATE257156T1 (de) * 1997-03-24 2004-01-15 Kyowa Hakko Kogyo Kk (1,2,4)triazolo(1,5-c)pyrimidin-derivate
US6060481A (en) * 1998-05-28 2000-05-09 The Penn State Research Foundation Method for improving insulin sensitivity using an adenosine receptor antagonist
BR9914040A (pt) * 1998-09-22 2002-01-15 Kyowa Hakko Kogyo Kk Derivados de [1,2,4]triazolo[1,5-c]pirimidina e seu uso, medicamento, antagonista, agente para prevenir ou tratar doenças, bem como processo para prevenção ou tratamento de distúrbios
AU2003272886A1 (en) * 2002-09-24 2004-04-19 Kyowa Hakko Kogyo Co., Ltd. (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
EP1618109A2 (en) * 2003-04-09 2006-01-25 Biogen Idec MA Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
EP1856053A1 (en) 2005-01-14 2007-11-21 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
WO2014086594A1 (de) 2012-12-06 2014-06-12 Siemens Aktiengesellschaft Anordnung und verfahren zum eintragen von wärme in eine geologische formation mittels elektromagnetischer induktion
CN106916073A (zh) * 2017-01-20 2017-07-04 上海巧坤化工科技有限公司 一种大麦芽碱盐酸盐的合成方法
CA3089159A1 (en) * 2018-02-06 2019-08-15 Jiangsu Hengrui Medicine Co., Ltd. Pyrazolo[1,5-a][1,3,5]triazine-2-amine derivative, preparation method therefor and medical use thereof
JP7175034B2 (ja) * 2018-06-26 2022-11-18 チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド Ａ２ａ受容体拮抗薬として用いられるトリアゾロトリアジン誘導体
US11845751B2 (en) * 2018-06-26 2023-12-19 Zhejiang Vimgreen Pharmaceuticals, Ltd. Triazolotriazine derivatives as A2A receptor antagonists
BE1026602B1 (fr) 2018-09-27 2020-06-18 Iteos Therapeutics S A Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers
WO2020103939A1 (zh) * 2018-11-22 2020-05-28 上海科技大学 三唑并环类化合物、其制备方法、中间体和应用
CN112479956A (zh) * 2019-07-30 2021-03-12 杭州阿诺生物医药科技有限公司 一种用于制备腺苷受体抑制剂中间体的方法
EP4083044A4 (en) * 2019-12-26 2024-03-27 Zhejiang Vimgreen Pharmaceuticals Ltd USE OF TRIAZOLOTRIAZINE DERIVATIVES TO TREAT DISEASES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269859A2 (en) * 1986-10-31 1988-06-08 Otsuka Pharmaceutical Co., Ltd. Pyrazolotriazine compounds
EP0281367A1 (en) * 1987-03-02 1988-09-07 Riker Laboratories, Inc. Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators
EP0297651A1 (en) * 1987-06-29 1989-01-04 Duphar International Research B.V Anellated indole derivatives
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846423A (en) * 1972-06-08 1974-11-05 Icn Pharmaceuticals Pyrazolo (1,5a) 1,3,5-triazines
ZA743316B (en) * 1973-05-22 1976-01-28 Sandoz Ltd Improvements in or relating to organic compounds
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
GB1579932A (en) * 1976-05-12 1980-11-26 Ici Ltd Herbicidal triazolotriazines
GB2016002B (en) * 1978-01-09 1982-05-06 Aron Sa Amino derivatives of pyrazolo(1,5-a)s triazine
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
CA1267143A (en) * 1985-06-06 1990-03-27 Sun H. Kim Anti-arthritic 7-phenylpyrazole[1,5-a]-1,3,5- triazine derivatives
US4970142A (en) * 1989-02-16 1990-11-13 Konica Corporation Silver halide photographic light-sensitive material containing cyan coupler

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269859A2 (en) * 1986-10-31 1988-06-08 Otsuka Pharmaceutical Co., Ltd. Pyrazolotriazine compounds
EP0281367A1 (en) * 1987-03-02 1988-09-07 Riker Laboratories, Inc. Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators
EP0297651A1 (en) * 1987-06-29 1989-01-04 Duphar International Research B.V Anellated indole derivatives
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives

Also Published As

Publication number Publication date
KR910020012A (ko) 1991-12-19
AU7734891A (en) 1991-12-05
IL98316A0 (en) 1992-06-21
NO178401C (no) 1996-03-20
IL98316A (en) 1995-05-26
JP2504879B2 (ja) 1996-06-05
YU94791A (sh) 1994-06-24
RO109542B1 (ro) 1995-03-30
CS159591A3 (en) 1992-01-15
HU911789D0 (en) 1991-12-30
NO912051D0 (no) 1991-05-28
NO178401B (no) 1995-12-11
EP0459702A1 (en) 1991-12-04
PT97776A (pt) 1992-03-31
GB2244487A (en) 1991-12-04
FI912563A0 (fi) 1991-05-28
CN1056879A (zh) 1991-12-11
HUT61311A (en) 1992-12-28
OA09358A (fr) 1992-09-15
YU47812B (sr) 1996-01-09
IE911818A1 (en) 1991-12-04
NO912051L (no) 1991-12-02
GB2244487B (en) 1994-02-02
CA2043424A1 (en) 1991-11-30
GB9111132D0 (en) 1991-07-17
NZ238288A (en) 1993-07-27
FI912563A (fi) 1991-11-30
JPH0597855A (ja) 1993-04-20
AU642494B2 (en) 1993-10-21
US5270311A (en) 1993-12-14
AP9100266A0 (en) 1991-07-31

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