AP248A - Azole derivatives. - Google Patents

Azole derivatives. Download PDF

Info

Publication number
AP248A
AP248A APAP/P/1991/000266A AP9100266A AP248A AP 248 A AP248 A AP 248A AP 9100266 A AP9100266 A AP 9100266A AP 248 A AP248 A AP 248A
Authority
AP
ARIPO
Prior art keywords
furyl
amino
triazine
formula
alkyl
Prior art date
Application number
APAP/P/1991/000266A
Other languages
English (en)
Other versions
AP9100266A0 (en
Inventor
Peter William Rodney Caulkett
Geraint Jones
Michael George Collis
Simon Martin Poucher
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909011914A external-priority patent/GB9011914D0/en
Priority claimed from GB909011913A external-priority patent/GB9011913D0/en
Priority claimed from GB919101380A external-priority patent/GB9101380D0/en
Priority claimed from GB919101379A external-priority patent/GB9101379D0/en
Priority claimed from GB919104125A external-priority patent/GB9104125D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AP9100266A0 publication Critical patent/AP9100266A0/xx
Application granted granted Critical
Publication of AP248A publication Critical patent/AP248A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1991/000266A 1990-05-29 1991-05-28 Azole derivatives. AP248A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909011914A GB9011914D0 (en) 1990-05-29 1990-05-29 Heterocyclic compounds
GB909011913A GB9011913D0 (en) 1990-05-29 1990-05-29 Azole derivatives
GB919101380A GB9101380D0 (en) 1991-01-22 1991-01-22 Azole derivatives
GB919101379A GB9101379D0 (en) 1991-01-22 1991-01-22 Heterocyclic compounds
GB919104125A GB9104125D0 (en) 1991-02-27 1991-02-27 Azole derivatives

Publications (2)

Publication Number Publication Date
AP9100266A0 AP9100266A0 (en) 1991-07-31
AP248A true AP248A (en) 1993-03-16

Family

ID=27516979

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000266A AP248A (en) 1990-05-29 1991-05-28 Azole derivatives.

Country Status (20)

Country Link
US (1) US5270311A (fr)
EP (1) EP0459702A1 (fr)
JP (1) JP2504879B2 (fr)
KR (1) KR910020012A (fr)
CN (1) CN1056879A (fr)
AP (1) AP248A (fr)
AU (1) AU642494B2 (fr)
CA (1) CA2043424A1 (fr)
CS (1) CS159591A3 (fr)
FI (1) FI912563A (fr)
GB (1) GB2244487B (fr)
HU (1) HUT61311A (fr)
IE (1) IE911818A1 (fr)
IL (1) IL98316A (fr)
NO (1) NO178401C (fr)
NZ (1) NZ238288A (fr)
OA (1) OA09358A (fr)
PT (1) PT97776A (fr)
RO (1) RO109542B1 (fr)
YU (1) YU47812B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226735D0 (en) * 1992-12-22 1993-02-17 Ici Plc Azole derivatives
US5356894A (en) * 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
EP0459702A1 (fr) * 1990-05-29 1991-12-04 Zeneca Limited Dérivés d'azoles
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
GB9124968D0 (en) * 1991-11-25 1992-01-22 Ici Plc Chemical process
GB9125001D0 (en) * 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
CA2144330A1 (fr) * 1993-07-27 1995-02-09 Fumio Suzuki Agent therapeutique pour la maladie de parkinson
EP0667349B1 (fr) * 1993-09-06 2001-01-24 Kyowa Hakko Kogyo Kabushiki Kaisha Antidepresseur
CA2284737C (fr) * 1997-03-24 2007-03-13 Kyowa Hakko Kogyo Co., Ltd. Derives [1,2,4]triazolo[1,5-c]pyrimidiniques
US6060481A (en) * 1998-05-28 2000-05-09 The Penn State Research Foundation Method for improving insulin sensitivity using an adenosine receptor antagonist
EA200100265A1 (ru) * 1998-09-22 2001-10-22 Киова Хакко Когио Ко., Лтд. Производные [1,2,4]триазоло[1,5-c]пиримидина
CA2500228A1 (fr) * 2002-09-24 2004-04-08 Kyowa Hakko Kogyo Co., Ltd. Derive de [1,2,4]-triazolo[1,5]pyrimidine
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
WO2004092170A2 (fr) * 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolotriazines et pyrazolotriazines et leurs procedes de fabrication et d'utilisation
EP1633756B1 (fr) 2003-04-09 2008-12-24 Biogen Idec MA Inc. Antagonistes de recepteur d'adenosine a2a
EP1618109A2 (fr) * 2003-04-09 2006-01-25 Biogen Idec MA Inc. Triazolo [1,5-c]pyrimidines et pyrazolo [1,5-c]pyrimidines et procedes de preparation et d'utilisation de celles-ci
WO2004110454A1 (fr) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. Composition de traitement ou de prevention de maladies necessitant l'administration d'un agoniste du recepteur a2a de l'adenosine
JP2008527007A (ja) 2005-01-14 2008-07-24 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Ｒａｆ−キナーゼ阻害活性を有するシンナミドおよびヒドロシンナミド誘導体
US10087715B2 (en) 2012-12-06 2018-10-02 Siemens Aktiengesellschaft Arrangement and method for introducing heat into a geological formation by means of electromagnetic induction
CN106916073A (zh) * 2017-01-20 2017-07-04 上海巧坤化工科技有限公司 一种大麦芽碱盐酸盐的合成方法
WO2019154294A1 (fr) * 2018-02-06 2019-08-15 江苏恒瑞医药股份有限公司 Dérivé de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procédé de préparation et son utilisation médicale
CA3115900A1 (fr) * 2018-06-26 2020-01-02 Zhejiang Vimgreen Pharmaceuticals, Ltd Derives de triazolotriazine en tant qu'antagonistes du recepteur a2a
CA3103068C (fr) * 2018-06-26 2024-06-25 Zhejiang Vimgreen Pharmaceuticals, Ltd Derives de triazolotriazine en tant qu'antagonistes du recepteur a2a
BE1026602B1 (fr) 2018-09-27 2020-06-18 Iteos Therapeutics S A Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers
CN111205291B (zh) * 2018-11-22 2022-08-23 上海科技大学 三唑并环类化合物、其制备方法、中间体和应用
CN112479956A (zh) * 2019-07-30 2021-03-12 杭州阿诺生物医药科技有限公司 一种用于制备腺苷受体抑制剂中间体的方法
JP2023508182A (ja) * 2019-12-26 2023-03-01 チェジン ヴィムグリーン ファーマシューティカルズ リミテッド トリアゾロトリアジン誘導体の疾患治療への応用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269859A2 (fr) * 1986-10-31 1988-06-08 Otsuka Pharmaceutical Co., Ltd. Composés de pyrazolotriazine
EP0281367A1 (fr) * 1987-03-02 1988-09-07 Riker Laboratories, Inc. 1,2,4-Triazolo[1,5-a]triazines substituées comme dilatatrices des bronches
EP0297651A1 (fr) * 1987-06-29 1989-01-04 Duphar International Research B.V Dérivés d'indole annulaires
EP0459702A1 (fr) * 1990-05-29 1991-12-04 Zeneca Limited Dérivés d'azoles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846423A (en) * 1972-06-08 1974-11-05 Icn Pharmaceuticals Pyrazolo (1,5a) 1,3,5-triazines
ZA743316B (en) * 1973-05-22 1976-01-28 Sandoz Ltd Improvements in or relating to organic compounds
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
GB1579932A (en) * 1976-05-12 1980-11-26 Ici Ltd Herbicidal triazolotriazines
GB2016002B (en) * 1978-01-09 1982-05-06 Aron Sa Amino derivatives of pyrazolo(1,5-a)s triazine
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
CA1267143A (fr) * 1985-06-06 1990-03-27 Sun H. Kim Derives de 7-phenylpyrazole[1,5-a]-1,3,5-triazine, agents anti-arthrite
EP0217748B1 (fr) * 1985-09-30 1991-02-06 Ciba-Geigy Ag [1,2,4]Triazolo[1,5-c]pyrimidines condensées en e et substituées en 2, compositions pharmaceutiques et leur utilisation
DE3781080T2 (de) * 1986-09-30 1992-12-24 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
US4970142A (en) * 1989-02-16 1990-11-13 Konica Corporation Silver halide photographic light-sensitive material containing cyan coupler

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269859A2 (fr) * 1986-10-31 1988-06-08 Otsuka Pharmaceutical Co., Ltd. Composés de pyrazolotriazine
EP0281367A1 (fr) * 1987-03-02 1988-09-07 Riker Laboratories, Inc. 1,2,4-Triazolo[1,5-a]triazines substituées comme dilatatrices des bronches
EP0297651A1 (fr) * 1987-06-29 1989-01-04 Duphar International Research B.V Dérivés d'indole annulaires
EP0459702A1 (fr) * 1990-05-29 1991-12-04 Zeneca Limited Dérivés d'azoles

Also Published As

Publication number Publication date
IE911818A1 (en) 1991-12-04
AP9100266A0 (en) 1991-07-31
HUT61311A (en) 1992-12-28
AU7734891A (en) 1991-12-05
CA2043424A1 (fr) 1991-11-30
CN1056879A (zh) 1991-12-11
EP0459702A1 (fr) 1991-12-04
GB9111132D0 (en) 1991-07-17
RO109542B1 (ro) 1995-03-30
NO912051D0 (no) 1991-05-28
GB2244487B (en) 1994-02-02
KR910020012A (ko) 1991-12-19
OA09358A (fr) 1992-09-15
GB2244487A (en) 1991-12-04
IL98316A (en) 1995-05-26
IL98316A0 (en) 1992-06-21
US5270311A (en) 1993-12-14
HU911789D0 (en) 1991-12-30
NZ238288A (en) 1993-07-27
CS159591A3 (en) 1992-01-15
YU94791A (sh) 1994-06-24
YU47812B (sr) 1996-01-09
NO178401B (no) 1995-12-11
PT97776A (pt) 1992-03-31
JP2504879B2 (ja) 1996-06-05
NO178401C (no) 1996-03-20
AU642494B2 (en) 1993-10-21
FI912563A (fi) 1991-11-30
FI912563A0 (fi) 1991-05-28
NO912051L (no) 1991-12-02
JPH0597855A (ja) 1993-04-20

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